DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment park and RNF217

DIOPT Version :9

Sequence 1:	NP_730600.1	Gene:	park / 40336	FlyBaseID:	FBgn0041100	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_011533796.1	Gene:	RNF217 / 154214	HGNCID:	21487	Length:	567	Species:	Homo sapiens

Alignment Length:	418	Identity:	90/418 - (21%)
Similarity:	134/418 - (32%)	Gaps:	139/418 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PLNETLLDLQLESEE-------RLNITDEE-----------RVR-------------------AK 156
            |||...|.||||.||       |....||:           |.|                   ||
Human    95 PLNPQTLPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAK 159

  Fly   157 AHFF--VHCSQCD-KLCNGKLRVRCALCKGGAFTVHRDPECWDDVLKSRRIPGHCESL------- 211
            ...|  |:|.:.| .......::.......||..|...|..... ..|.|:....:||
Human   160 RQVFCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPSTRSS-FPSPRLSLPTDSLSPDGGSI 223

  Fly   212 --------EVACVDNAAGDPPFAEFFFKCAEHVSGGEKDFAAPLNLIKNNIKNVPCLACTDVSDT 268
                    |...:.:..|.||::..         ||..|...||.::.       |..|.: ...
Human   224 ELEFYLAPEPFSMPSLLGAPPYSGL---------GGVGDPYVPLMVLM-------CRVCLE-DKP 271

  Fly   269 VLVFPCASQHVTCIDCFRHY--CRSRLGERQFMPHPDFGYTLPCPAGCEHSFIEEIHHFKLLTRE 331
            :...||..:.| |.:|.:.|  .:.:||:.:          :.||......|:||......||.|
Human   272 IKPLPCCKKAV-CEECLKVYLSAQVQLGQVE----------IKCPITECFEFLEETTVVYNLTHE 325

  Fly   332 EYDRYQRFATEEYVLQAGGVLCPQPGCGMGLLVEPDCR---------------------KVTCQN 375
            :..:|      :|.|:.|.:......|       |.|:                     |:.|..
Human   326 DSIKY------KYFLELGRIDSSTKPC-------PQCKHFTTFKKKGHIPTPSRSESKYKIQCPT 377

  Fly   376 GCGYVFCRNCLQGYHIGECLPEGTGASATNSCEYTVDPNRAAEARWDEASNVTI-KVSTKPCPKC 439
             |.:|:|..|...:|.|           .|..||.......  ..|  ||.:.. :.:.:.||||
Human   378 -CQFVWCFKCHSPWHEG-----------VNCKEYKKGDKLL--RHW--ASEIEHGQRNAQKCPKC 426

  Fly   440 RTPTERDGGCMHMVCTRAGCGFEWCWVC 467
            :...:|..||.||.|::  |...:|:.|
Human   427 KIHIQRTEGCDHMTCSQ--CNTNFCYRC 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
park	NP_730600.1	UBQ	30..97	CDD:214563
		parkin_N	32..101	CDD:176393
		IBR	334..390	CDD:214763	13/76 (17%)
		IBR	<435..471	CDD:279784	13/33 (39%)
RNF217	XP_011533796.1	IBR	329..396	CDD:214763	15/91 (16%)
		InsA	338..>382	CDD:226202	6/51 (12%)
		IBR	<418..456	CDD:279784	13/37 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1140368at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920