DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac78C and Phlpp1

DIOPT Version :9

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:1219 Identity:222/1219 - (18%)
Similarity:373/1219 - (30%) Gaps:435/1219 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   707 SGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTE--PLRPKRRFGTRS- 768
            :||:|.....| |:|               |    .:.|:.||.|:|..:  .|:|..|...|. 
Mouse   129 AGGLPASCSAS-ASL---------------C----TRSLDRKTLLLKHRQLLQLQPSDRDWVRHQ 173

  Fly   769 ---------SAHLAGSV---------ATAA------------------------PPCATPTALPK 791
                     ..|:|.|.         .|||                        ||.|.|.|..:
Mouse   174 LQRGCVHVFDRHMASSYLRPVLCTLDTTAAEVAARLLQLGHKGGGVVKVLGYGPPPAAAPAASDQ 238

  Fly   792 SISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGV 856
            ::.......:....::|..|| :.|.:....|.:.:|....|:...:       ::..|:     
Mouse   239 TLDGEHGRDVEPPPSSGTVGA-VRGPARAPPADLPLPGGAWTRCAPR-------ISPAPS----- 290

  Fly   857 AMDSRRIRNGCGVMGGAG-------------------------------GTGGGGTGPCGMSTVS 890
              ||   ..|....||.|                               .:||||:........:
Mouse   291 --DS---SPGELFAGGPGSPPRAPRPASDTESFSLSPSAESVSDRLDPYSSGGGGSSSSSEELEA 350

  Fly   891 SPTAMMSAP-LEVQLR---PRNGACSIQNLAEAIDGKGLII-----EDESTTDWIPEIPFKNLNS 946
            .| ||...| ...|.|   |:..|.........:|..|:|.     :|::.....|::|......
Mouse   351 DP-AMPHRPGRPAQPRPPSPKTSALLQPKAPTGVDSTGVIAGEGPGDDKAMAAAAPDVPLSTSGR 414

  Fly   947 PEDGLNR-------------------ADSILVDTKEDH----------RVSVAVLDEEIDEFI-- 980
            ..:.:.:                   ||...:..:.|:          ||....:|.||...|  
Mouse   415 IRETVQKTSPPSLYVQLHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRF 479

  Fly   981 ----------EQNIQINSNKEIRREYL----NPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVI 1031
                      .:.||::....:|:..:    |.||.:                            
Mouse   480 YAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRR---------------------------- 516

  Fly  1032 WIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVM----AEEFPGLPRCLKTNSAKLVHQRQR 1092
                   |||:   |...:|..||...:.....||.:    .||......||..:|:    ..|.
Mouse   517 -------QVIL---CGTCLIVSSVKDSVSGKMHVLPLIGGKVEEVKKHQHCLAFSSS----GPQS 567

  Fly  1093 RTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSN--ISMTEKEFKLNVYLSA 1155
            :|.:||                      ..|..|:.|:||.||..::  ||..:.......:|.|
Mouse   568 QTYYIC----------------------FDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPA 610

  Fly  1156 TIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLT--TNGHSV 1218
            .:.::              .|:|.......|:|.         ||.||.:.....|.  |...|:
Mouse   611 NLFYS--------------QDLTHLNLKQNFLRQ---------TPTLPAARGLGELQRFTKLKSL 652

  Fly  1219 SLSNLSYSDASVMQSSSDVEGQCAHPEYL-VFTWVLCLVSLATALKLYYLVKALMALA-----MV 1277
            :|||                      .:| .|...:|  |:.|..:|.....||..:.     |.
Mouse   653 NLSN----------------------NHLGAFPSAVC--SIPTLAELNVSCNALREVPAAVGDMQ 693

  Fly  1278 AFYTTLI---MMKFGSGDSFSLVELSRLGMPLG----VQMLILLISFLVMVCYHARLVEVTSRLD 1335
            ...|.|:   .::....:..|:.:||.||:...    :..::..::.:..:|.....|| |.|| 
Mouse   694 NLQTFLLDGNFLQSLPAELESMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCVE-TLRL- 756

  Fly  1336 FIWKEQAERELTNMKS-NRALNDTLIKNILPD------HVATYYLSDEHTDEL-------YSKMH 1386
                 ||.|.:.::|. :..||  :::.::.|      ||....|.|....:|       ...:|
Mouse   757 -----QALRRMPHIKHVDLRLN--ILRKLMADEVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVLH 814

  Fly  1387 ---------NLCG----VMFAS-----------IPNFQDFYSEDIDNGKACIRILNEIICD---- 1423
                     |:||    .::||           :||:..:    :|..:.|:..:.|.:|:    
Mouse   815 CERNQLVTLNVCGYFLKALYASSNELAQLDVYPVPNYLSY----MDVSRNCLESVPEWVCESRKL 875

  Fly  1424 ------FDELLEEPR----FASVEKIKTVGATYMAAAGLNHEHL-RLRGETSEDSV--------- 1468
                  .:::.|.|.    .:|:.|:         .||  |..| ||.......||         
Mouse   876 EVLDIGHNQICELPARLFCNSSLRKL---------LAG--HNRLARLPERLERTSVEVLDVQHNQ 929

  Fly  1469 -----------CDLVEFAFAMKQKLE--------EINGDAFNNFQLRVGICSG---PLVSGVIGA 1511
                       .|.:.|..|...|||        |..........|.....:.   ||::|  ..
Mouse   930 ITELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNCLTDKCVPLLTG--HP 992

  Fly  1512 RKPVYDIWGNTVN--VASRMDSTGENWRVQVPEN------TAELLCSRGYTCVKRGEIAVKGKGM 1568
            |..:..:..|.:.  .||:|....|...:.:..|      |..:.|.|.:|.:...........:
Mouse   993 RLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEV 1057

  Fly  1569 MTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQ--------RQTSHHGSFSAVVFGMLQASKR 1625
            |....|....:|.::| |.:.:|..:|    |.||        |....|.|..  :...::..|.
Mouse  1058 MQLPEVKCVDLSCNEL-SEITLPENLP----PKLQELDLTGNPRLALDHKSLE--LLNNIRCFKI 1115

  Fly  1626 STAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRG 1674
            ....||..:|.|:.. ..|:..::....:|...:.:||..|.|...:.|
Mouse  1116 DQPSAGDASGAPAVW-SHGYTEASGVKNKLCVAALSVNNFRDNREALYG 1163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831
CYCc 526..729 CDD:214485 6/21 (29%)
Guanylate_cyc 566..753 CDD:278633 11/45 (24%)
DUF1053 929..1020 CDD:283888 18/135 (13%)
CYCc 1353..1554 CDD:214485 53/291 (18%)
Guanylate_cyc 1381..1576 CDD:278633 49/279 (18%)
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406 33/194 (17%)
PH_PHLPP-like 491..587 CDD:270131 29/159 (18%)
PH 511..592 CDD:278594 28/144 (19%)
LRR_RI 581..885 CDD:238064 69/363 (19%)
LRR_8 594..659 CDD:290566 18/109 (17%)
LRR 1 594..615 4/20 (20%)
leucine-rich repeat 597..617 CDD:275380 2/33 (6%)
LRR 2 617..638 8/29 (28%)
leucine-rich repeat 618..648 CDD:275380 8/38 (21%)
LRR_8 647..726 CDD:290566 21/102 (21%)
LRR 3 648..669 7/44 (16%)
LRR 4 671..692 4/20 (20%)
leucine-rich repeat 672..694 CDD:275380 4/21 (19%)
LRR 5 694..715 2/20 (10%)
leucine-rich repeat 695..717 CDD:275380 3/21 (14%)
LRR 6 717..739 4/21 (19%)
leucine-rich repeat 718..740 CDD:275380 4/21 (19%)
LRR 7 740..760 8/26 (31%)
leucine-rich repeat 741..764 CDD:275380 9/29 (31%)
LRR 8 764..785 4/22 (18%)
LRR_RI 768..1030 CDD:238064 50/280 (18%)
leucine-rich repeat 768..788 CDD:275380 3/21 (14%)
LRR 9 788..809 5/20 (25%)
leucine-rich repeat 789..809 CDD:275380 4/19 (21%)
leucine-rich repeat 810..851 CDD:275380 7/40 (18%)
LRR 10 829..850 2/20 (10%)
LRR 11 851..872 4/24 (17%)
leucine-rich repeat 852..874 CDD:275380 4/25 (16%)
LRR 12 874..895 2/20 (10%)
leucine-rich repeat 875..897 CDD:275380 2/21 (10%)
LRR_8 896..954 CDD:290566 13/68 (19%)
LRR 13 897..918 8/31 (26%)
leucine-rich repeat 898..919 CDD:275380 7/31 (23%)
LRR 14 919..940 2/20 (10%)
leucine-rich repeat 920..943 CDD:275380 1/22 (5%)
LRR 15 943..964 5/20 (25%)
leucine-rich repeat 944..967 CDD:275380 6/22 (27%)
LRR 16 969..989 3/19 (16%)
LRR_8 970..1028 CDD:290566 11/59 (19%)
leucine-rich repeat 970..993 CDD:275380 4/24 (17%)
LRR 17 993..1014 5/20 (25%)
leucine-rich repeat 994..1017 CDD:275380 4/22 (18%)
LRR 18 1017..1038 3/20 (15%)
LRR 19 1040..1061 3/20 (15%)
LRR 20 1062..1083 5/21 (24%)
leucine-rich repeat 1063..1085 CDD:275380 6/26 (23%)
LRR 21 1085..1106 5/22 (23%)
PP2Cc 1124..1376 CDD:214625 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.