DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	1031	Identity:	216/1031 - (20%)
Similarity:	360/1031 - (34%)	Gaps:	322/1031 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   778 TAAPPCATPTA-LPKSISASG---SGSIGGVTATGN----D---GASIDGRSLEYAATIAVPAQQ 831
            |..||....:| |.:|:...|   .|..||.:|..:    |   ||..||....:..|.::....
Mouse   162 TLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWGAVEDGLQFHFNITASMRYNS 226

  Fly   832 PTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGC---GVMGG--------------------- 872
            .:..|.|:..:|:|..:...::...:.|:|||....   |:..|
Mouse   227 SSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFILLQQLEDSFWKEVLTK 291

  Fly   873 ----------------AGGTGGGGTGPCGM-----STVSSPTAMMSAPLEVQLRPRNG------- 909
                            |....|||.|..|.     ..:..|....|...|.|:.|.:.
Mouse   292 DKVIRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAYLHDALL 356

  Fly   910 --ACSIQNLAEA----IDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVS 968
              |.:::.:.:|    .||:.||     :|....::..:.:..|         :|:|::....|.
Mouse   357 LYAQTVEEMRKAEKDFRDGRQLI-----STLRAGQVTLQGITGP---------VLLDSQGKRHVD 407

  Fly   969 VAVLDEEIDEFIEQNIQINSNKEIRREYLN---------PWTLKFKDKS---------QEQKFCQ 1015
            .:|          ..:|.:.|:.:...:|:         ||.   .|.:         :.:..|.
Mouse   408 YSV----------YALQESGNRSLFLPFLHYDSFQKVIRPWR---NDSNTSWPHGSLPEYKPGCG 459

  Fly  1016 LREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPG------ 1074
            ...|:.::....|    ..|.:....:||..|.|::..:.....|....:....:..||
Mouse   460 FHNDLCKTKPPTV----AGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQI 520

  Fly  1075 -------LPRCLKTNSAKLVHQR---QRRTL---------FICGVIVSM-----CMLSAIGL--- 1112
                   ||:      .||.|:.   .||.:         ..||.:|..     ...:.:||
Mouse   521 RYDSITLLPQ------HKLSHRGTPVSRRNVSDTSTVKASADCGSLVKRHQDEELFFAPVGLYQG 579

  Fly  1113 ---VLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHH--------------N 1160
               .||    |||  ||...:::           :...:..|.|...:.|              |
Mouse   580 NQVALC----YIG--DEAEAWVK-----------KPTVRREVCLMCELKHENIVPFFGVCTEPPN 627

  Fly  1161 ITISTP--ASGGPTPLVDITSSGPSD-------EFVRSTLNALTLNLTPPLPQSH---RPYTLTT 1213
            |.|.|.  ..|.   |.|:..:...:       .|....:|.|......|| :||   :|.....
Mouse   628 ICIVTQYCKKGS---LQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPL-RSHGNLKPSNCLV 688

  Fly  1214 NGH-SVSLSNLSYSD-------ASVMQSSSD--------------VEGQCA-HPEYLVFTWVLCL 1255
            :.| .:.||.....:       .|..|.::|              .|..|: .|:..|:::.:.|
Mouse   689 DSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSGTPQGDVYSFAILL 753

  Fly  1256 VSL-------------ATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLV--------EL 1299
            ..|             |...::...:|.  ..|.|....:|:..| |.|...:||        ||
Mouse   754 RDLIHQQAHGPFEDLEAAPEEIISRIKD--PRAPVPLRPSLLEDK-GDGRIVALVRECWDESPEL 815

  Fly  1300 S----------RLGMPLG-VQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNR 1353
            .          |...|.| |.:|..::..|.....|  |.||.        |:..|||.   :.:
Mouse   816 RPIFPSIKKTLREASPRGHVSILDSMMGKLETYANH--LEEVV--------EERTRELV---AEK 867

  Fly  1354 ALNDTLIKNILPDHVATYYLS-----DEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKAC 1413
            ...:.|:..:||..|....::     .||.:.:        .:.|:.|..|....|  :.:....
Mouse   868 RKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESV--------TIFFSDIVGFTKLCS--LSSPLQV 922

  Fly  1414 IRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDL------V 1472
            :::||::...||..::.   ..|.|::|:|..||.|:||...:    |....|.:..:      |
Mouse   923 VKLLNDLYSLFDHTIQS---HDVYKVETIGDAYMVASGLPIRN----GAQHADEIATMALHLLSV 980

  Fly  1473 EFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWR 1537
            ...|.:....||       ..:||:|:.:||:|:||:|...|.|.::|:|||:||||:|:....|
Mouse   981 TTHFQIGHMPEE-------RLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLR 1038

  Fly  1538 VQVPENTA-ELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPK-GISESQLISPVRMP 1591
            :.|.::|| .||.:.||...|||.|:|||||..|||::..| |.       ||.:|
Mouse  1039 IHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGF-------PVPLP 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888	13/108 (12%)
		CYCc	1353..1554	CDD:214485	56/212 (26%)
		Guanylate_cyc	1381..1576	CDD:278633	63/201 (31%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	53/297 (18%)
		PK_GC	555..829	CDD:270894	55/297 (19%)
		CYCc	865..1055	CDD:214485	55/213 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900