DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	269	Identity:	79/269 - (29%)
Similarity:	127/269 - (47%)	Gaps:	59/269 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 ETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSIL 577
            :||:|:|.:|      ::|..||.||.|..|..|:             .|..::.....|:|::|
  Rat   476 KTHQALEEEK------KKTVDLLYSIFPGDVAQQL-------------WQRQQVQARKFDDVTML 521

  Fly   578 FADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPD 642
            |:||.|||.:.::.:..|::.:||:|:.|||.........:|:.:||. |||:
  Rat   522 FSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDA-YCVA------------ 573

  Fly   643 HAVCSVETGLH----------MIKAIKDVRLHTHV------DLNMRIGIHSGSVMCGVLGNKKWH 691
                   :|||          .:.|:|.:.|...|      .:.||||||||||:.||:|.:...
  Rat   574 -------SGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPR 631

  Fly   692 FDVWSNDVIIANHMESGGIPGRVHISEATLKCL--NDAYEVEP-GNGGCRDNHLKMLNVKTYLIK 753
            :.::.|:|.:|:..|||..|.|::||..|.:.|  .|::...| ......||..|.:....|.::
  Rat   632 YCLFGNNVTLASKFESGSHPRRINISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLE 696

  Fly   754 -RTEPLRPK 761
             ||.|..||
  Rat   697 LRTGPKPPK 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	13/37 (35%)
		CYCc	526..729	CDD:214485	64/220 (29%)
		Guanylate_cyc	566..753	CDD:278633	60/205 (29%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	11/30 (37%)
		CYCc	483..672	CDD:214485	65/227 (29%)
		Guanylate_cyc	512..696	CDD:278633	60/203 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900