DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy5

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1611	Identity:	454/1611 - (28%)
Similarity:	710/1611 - (44%)	Gaps:	415/1611 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MDDDKLVSDEVHLRQLSATPSSAFSLQHSRG---SDTKEEA---PPEGGTMG-----GKSAAPRE 78
            |...|.||...:..|.:|:|:.....:|...   :|::...   .|.|.|.|     |.:..|::
  Rat     1 MSGSKSVSPPGYAAQTAASPAPGGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQQ 65

  Fly    79 EGEPDERVVLRRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEE--VDGLGLSNPAAQTTDDEQIT 141
            :    :|:..|.   :|             ||||::..::|::  |.|.|.|..:.....:....
  Rat    66 Q----QRLASRW---RG-------------GDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGD 110

  Fly   142 VNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSI 206
            ..|.|:......||...|:                  |.|..|      |||....:..|:
  Rat   111 DGGRGSRRQRRGAAGGGST------------------RAPPAG------GSGSSAAAAAAA---- 147

  Fly   207 LSNLRKKQQGGPLRGGVAKQTPLRVQSVRI-VEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSL 270
                          ||    |.:|.:||.: :|.:|..|  |..|            :||.|...
  Rat   148 --------------GG----TEVRPRSVEVGLEERRGKG--RAAE------------ELEPGTGT 180

  Fly   271 ASIPGQSQRPLNNEMYSAFKSGNVVK-GILCPSL-----TNSFKQSSLERSYLTYTHRQRQKSL- 328
            .. .|.......:.:.|...:|.|:. |..|.:|     :..|....|||.|..|..|..|.||
  Rat   181 VE-DGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLT 244

  Fly   329 IIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAI----TWSVCCGIANMAICFLGYWRC 389
            :::.|:..|..::|||     .:...|::......:|.|:    ..:|.|..|......:|. .|
  Rat   245 MLMAVLVLVCLVMLAF-----HAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL-AC 303

  Fly   390 FANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITA 454
            :|...:..|.....:|........:|         :|:.:|.|:..|.:||:.::..|:.|.:.:
  Rat   304 YALIAVVLAVQVVGLLLPQPRSASEG---------IWWTVFFIYTIYTLLPVRMRAAVLSGVLLS 359

  Fly   455 SCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAME 519
            :.|||:..     |..|  ..:.:|.|:.:|.::::..|:.|:.|.|..:..||.||.||.:.::
  Rat   360 ALHLAISL-----HTNA--QDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQ 417

  Fly   520 HKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGF 584
            .:..|::|.|:.::||.|:||..|..::::::....:   :..|:|:|:...||||||||||:||
  Rat   418 ARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE---DMMFHKIYIQKHDNVSILFADIEGF 479

  Fly   585 TELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVE 649
            |.|||:.:||:||..||:||||||::|.:|||||:|:|||||||||...    :.|.|||.|.||
  Rat   480 TSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVE 540

  Fly   650 TGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRV 714
            .|:.||:||..||..|.|::|||:|||||.|.|||||.:||.||||||||.:|||||:||..||:
  Rat   541 MGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRI 605

  Fly   715 HISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATA 779
            ||::|||..||..||||||.||.|:.:||..:::|:||.|
  Rat   606 HITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILR------------------------- 645

  Fly   780 APPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNI 844
               |.                                                     |::|:..
  Rat   646 ---CT-----------------------------------------------------QKRKEEK 654

  Fly   845 SLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNG 909
            ::         :|..:|:..|..|
  Rat   655 AM---------IAKMNRQRTNSIG----------------------------------------- 669

  Fly   910 ACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNL---NSPEDGLNRADSILVDTKEDHRVSVAV 971
                                .:...|..|.||.|.   |.....:.|..  ..|.|:.:....|.
  Rat   670 --------------------HNPPHWGAERPFYNHLGGNQVSKEMKRMG--FEDPKDKNAQESAN 712

  Fly   972 LDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMV 1036
            .::|:|||:.:.|...|...:|.|::..:.|.|::...|:|:.:..:|.|.:.:.|..::::|:.
  Rat   713 PEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFIC 777

  Fly  1037 LCQVIIIPR----------CTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQ 1091
            ..|:.|:|.          |..|:..:...:||  :.||.:       .|..|:|.|.|:|..::
  Rat   778 FVQITIVPHSLFMLSFYLSCFLLLALVVFISVI--YACVKL-------FPTPLQTLSRKIVRSKK 833

  Fly  1092 RRTLFICGVI-VSMCMLSA-IGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLS 1154
            ..||  .||. :::..||| :.:.:|.|...:|...|
  Rat   834 NSTL--VGVFTITLVFLSAFVNMFMCNSKNLVGCLAE---------------------------- 868

  Fly  1155 ATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVS 1219
               .||||::                                               ..|...|.
  Rat   869 ---EHNITVN-----------------------------------------------QVNACHVM 883

  Fly  1220 LSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLI 1284
            .|..:||...........:..|..|||..::.:|.|::.:..|::..:.|.::.||:...|..::
  Rat   884 ESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIV 948

  Fly  1285 ----MMKFGSGD---SFSLVELSRLG----------MPLGVQMLILLISFLVMVCYHARLVEVTS 1332
                :..|.:.|   :.:.::.|..|          :.|.|...|::..|::.:..||:.||.|:
  Rat   949 EVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTA 1013

  Fly  1333 RLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-HTDELYSKMHNLCGVMFASI 1396
            ||||:||.||..|...|:..:|.|..|:.||||..||.::|:.| ..||||.:......||||||
  Rat  1014 RLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASI 1078

  Fly  1397 PNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRL 1459
            .||.:||.| :.:| |..|:|:|||||.||||::.|.||..:|||||:|:|||||:|||......
  Rat  1079 ANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDK 1143

  Fly  1460 RGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVN 1524
            .|:|   .:..|.:||..:..:::.||..:|||||:::|:..||:|:||||||||.|||||||||
  Rat  1144 AGKT---HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVN 1205

  Fly  1525 VASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575
            |||||||||...|:||..:..::|.:..|....||.:.|||||.|.|::::
  Rat  1206 VASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	67/273 (25%)
		CYCc	526..729	CDD:214485	111/202 (55%)
		Guanylate_cyc	566..753	CDD:278633	114/186 (61%)
		DUF1053	929..1020	CDD:283888	22/93 (24%)
		CYCc	1353..1554	CDD:214485	102/203 (50%)
		Guanylate_cyc	1381..1576	CDD:278633	99/197 (50%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	122/563 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196		54/275 (20%)
		Guanylate_cyc	461..634	CDD:306677	110/176 (63%)
		DUF1053	669..761	CDD:399378	23/154 (15%)
		Guanylate_cyc	1063..1257	CDD:306677	99/197 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710