DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy3

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_570135.2	Gene:	Adcy3 / 64508	RGDID:	71009	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	1419	Identity:	408/1419 - (28%)
Similarity:	618/1419 - (43%)	Gaps:	354/1419 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 GNSNFEHDLE-SGNSLASIPGQSQRPL-NNEMYSAFKSGNVVKGILC-PSLTN-SFKQSSLERSY 316
            |.|:.|:..| |.....|:|....|.: .....|...||:    .|| |.... :|...|||..|
  Rat     6 GFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGS----CLCLPRFMRLTFVPESLENLY 66

  Fly   317 LTYTHRQRQKSLIIVNVVD--FVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCC----- 374
            .||..|||.::|:::.|..  |...:|:....:....:|.|: ...|..:...|...|.|
  Rat    67 QTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPL-MVAGVGLVLDIILFVLCKKGLL 130

  Fly   375 --GIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGF----ADREYLVWYILFVIF 433
              .::...:.:|                 .|:|...|.|...|:.|    |..:.:.|...|| |
  Rat   131 PDRVSRKVVPYL-----------------LWLLITAQIFSYLGLNFSRAHAASDTVGWQAFFV-F 177

  Fly   434 VPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMY 498
            ..:..|||.|...|:...::...|..|:.:...|..:..:....:|.:|.||..||....:.|:.
  Rat   178 SFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIM 242

  Fly   499 TKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQF 563
            :.|:.||..|.||:|..:::|.|...|::.|:.:.|:.||||..|.:::..:|.|......:.||
  Rat   243 SYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQF 307

  Fly   564 NKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYC 628
            |.:|:|..:|||||||||.|||:|:|..|||:|||:||:||||||::|...|.||:|:|||||||
  Rat   308 NTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYC 372

  Fly   629 VSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFD 693
            :.....    .|.||||||:..||.|::||..||..|...::||:|:|:|:|:.||||.|:|.:|
  Rat   373 ICGLPD----YREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   694 VWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPL 758
            |||.||.:||.||:||||||||||::|:.||...::||||:||.|.::|....::||||..::|.
  Rat   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPE 498

  Fly   759 RPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAA 823
            ..|     .:...|.||......|.:.|:: |..|.          |...|..|...|.:.|.|.
  Rat   499 VKK-----TAQNGLNGSALPNGAPASKPSS-PALIE----------TKEPNGSAHASGSTSEEAE 547

  Fly   824 TIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMST 888
            .....|..|               |.||       ..||:|
  Rat   548 EQEAQADNP---------------SFPN-------PRRRLR------------------------ 566

  Fly   889 VSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNR 953
                                    :|:||:.:
  Rat   567 ------------------------LQDLADRV--------------------------------- 574

  Fly   954 ADSILVDTKEDHR-----VSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKF 1013
                 ||..||..     ::.|:|:.|..:.:::          |..:|  .|::|.|...|.::
  Rat   575 -----VDASEDEHELNQLLNEALLERESAQVVKK----------RNTFL--LTMRFMDPEMETRY 622

  Fly  1014 CQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFP-GLPR 1077
            ...:|....:...|..|:.....:.:::|.|......:...||.|:|....:..||..|| ..|:
  Rat   623 SVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRAFPK 687

  Fly  1078 CLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISM 1142
            .|...|:.:...|..|..:....|..:.|.:.:.::.|
  Rat   688 KLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSC--------------------------- 725

  Fly  1143 TEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHR 1207
                  |..|:.
  Rat   726 ------LQYYMG----------------------------------------------------- 731

  Fly  1208 PYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQC-AHPEYLVFTWVLCLVSLATALKLYYLVKAL 1271
            ||.:||                    ..:::|.| .:|:|..:..||.|::....:::.::||..
  Rat   732 PYNVTT--------------------GIELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLT 776

  Fly  1272 MALAMVAFYTTLIM------------MKFGSGDS--FSLVELSRLGMP----------------- 1305
            :.|.:....|.:.:            .:|...||  .:|.::..|..|
  Rat   777 LMLLVTGAVTAINLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYS 841

  Fly  1306 LGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVAT 1370
            :.|.|.::::||.    |.:|.||..:|..|:||.:...:...:...|..|:.|:.|:||:|||.
  Rat   842 MTVMMFVMMLSFY----YFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVAR 902

  Fly  1371 YYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSED-IDNGK-ACIRILNEIICDFDELLEEPR 1432
            ::| |.:..:||||:.::..||||||:|||.|||:|: |:||. .|:|.|||||.|||.||:.|:
  Rat   903 HFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPK 967

  Fly  1433 FASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDS-----------VCDLVEFAFAMKQKLEEIN 1486
            |..:.||||:|:|||||:|:..: :...|.||...           :.||.:||.|||..|..||
  Rat   968 FRVITKIKTIGSTYMAASGVTPD-VNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNIN 1031

  Fly  1487 GDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSR 1551
            ..:||||.||:|:..|.:::||||||||.||||||||||||||:|||....:||.|.|..:|...
  Rat  1032 NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096

  Fly  1552 GYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQ 1605
            |:..|:||.|.|||||.:.||::  ||...         ||..|...:..|..|
  Rat  1097 GFRFVRRGPIFVKGKGELLTFFL--KGRDR---------PAAFPNGSSVTLPHQ 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	69/277 (25%)
		CYCc	526..729	CDD:214485	104/202 (51%)
		Guanylate_cyc	566..753	CDD:278633	103/186 (55%)
		DUF1053	929..1020	CDD:283888	14/95 (15%)
		CYCc	1353..1554	CDD:214485	108/214 (50%)
		Guanylate_cyc	1381..1576	CDD:278633	107/207 (52%)
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	70/281 (25%)
		Guanylate_cyc	310..494	CDD:306677	104/187 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..563		18/91 (20%)
		Guanylate_cyc	914..1121	CDD:306677	107/209 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710