DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	764	Identity:	164/764 - (21%)
Similarity:	286/764 - (37%)	Gaps:	220/764 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ICLRTAEEGQLANMDDDKLVSDEVHLRQLSAT------PSSA---FSLQHSRGSDTKEEAPPEGG 67
            ||....|:....::...|...:.|:|..|:.:      |...   .:||.:......||
Mouse    46 ICQYFPEKNAEGSLPQRKTSRNRVYLHTLAESICKLIFPECERLNLALQRTLAKHKIEE------ 104

  Fly    68 TMGGKSAAPREEGEPDERVVLRRAVDKGAIALAQIDDL-----KLEGDDDDE--AVVNGEEVDGL 125
              ..||:    |.|..|:::...|:..||...|..|.|     |:..::|:.  .||.|...|.|
Mouse   105 --NRKSS----EKEDLEKIIAEEAIAAGAPVEALKDSLGEELFKICYEEDEHILGVVGGTLKDFL 163

  Fly   126 -GLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPG---DGAQ 186
             ..|....|::..::  ....|....:|:.  ....:||..:.....|..:....|||   ..|:
Mouse   164 NSFSTLLKQSSHCQE--AERRGRLEDASIL--CLDKDQDFLNVYYFFPKRTTALLLPGIIKAAAR 224

  Fly   187 M--EDNGSGDL-PPSLRASTTSILSNLRKKQQGGPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRR 248
            :  |.:....| ||..|:..|..::.                  |..:.||.:...|.:..|.:.
Mouse   225 ILYESHVEVSLMPPCFRSDCTEFVNQ------------------PYLLYSVHVKSTKPSLSPGKP 271

  Fly   249 TES----CSIFGNS---NFEHD-----LESGNSLASIPGQSQ---RPLNNEMYSAFKSGNVVKGI 298
            ..|    .|:|..:   :|..|     |:.||.:..:..:..   :|...|.:.          |
Mouse   272 QSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFE----------I 326

  Fly   299 LCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTS 363
            |.|.:..:|.      ..:|..:.|            ||:::        ||.:    .|...:|
Mouse   327 LTPKINQTFS------GIMTMLNMQ------------FVIRV--------RRWD----NSVKKSS 361

  Fly   364 MATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYI 428
            ....:...:...:.:.||.|||             :.|   :..::.|.|:|:..:|
Mouse   362 RVMDLKGQMIYIVESSAILFLG-------------SPC---VDRLEDFTGRGLYLSD-------- 402

  Fly   429 LFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAIN 493
                        :|:             |.|:..::.:  ||.....:
Mouse   403 ------------IPI-------------HNALRDVVLI--GEQARAQD----------------- 423

  Fly   494 VAGMYTKYLTDRGQRLAFIE-THKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDP 557
              |:..:.    |:..|.:| .|:|:|.:|      :||..||.||.|    :::..::::|  .
Mouse   424 --GLKKRL----GKLKATLEHAHQALEEEK------KRTVDLLCSIFP----SEVAQQLWQG--Q 470

  Fly   558 TVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLL 622
            .|:.:       ....|::||:||.|||.:.|:.|..|::.:||.|:.|||:...:....:|:.:
Mouse   471 IVQAK-------KFSEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETI 528

  Fly   623 GDCYYCVS---QFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGV 684
            ||. |||:   ..|||.      |||......|.|::...:|.......:.||||:|||||..||
Mouse   529 GDA-YCVAGGLHRESDT------HAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGV 586

  Fly   685 LGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPG 733
            :|.|...:.::.|:|.:||..||..:|.::::|..|.:.|.|.    ||
Mouse   587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC----PG 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	42/263 (16%)
		CYCc	526..729	CDD:214485	65/205 (32%)
		Guanylate_cyc	566..753	CDD:278633	58/171 (34%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	51/312 (16%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	59/178 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900