DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	1002	Identity:	179/1002 - (17%)
Similarity:	315/1002 - (31%)	Gaps:	348/1002 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   876 TGGGGTGPCGMSTVSSPTAMMSAP--------LEVQLR---PRNGACSIQNLAEAIDGKGLII-- 927
            :.|||:........:.|..:::.|        ...|.|   |:..|.........:||.||::
  Rat   334 SSGGGSSSSSEELEADPATVLTGPSGPPHHPVRSSQPRPPSPKTSALLQPKAPTGVDGTGLVVGE 398

  Fly   928 ---EDESTTDWIPEIP--------------------FKNLNSPEDGLNRADSILVDTKEDH---- 965
               :|::.....|.:|                    :..|:........||...:..:.|:
  Rat   399 GPGDDKAVAAAAPGVPLWTPGRIRETVQKTSSPPSLYVQLHGETTRRLEADEKPLQIQNDYLFQL 463

  Fly   966 ------RVSVAVLDEEIDEFI------------EQNIQINSNKEIRREYL----NPWTLKFKDKS 1008
                  ||....:|.||...|            .:.||::....:|:..:    |.||.:
  Rat   464 GFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRR----- 523

  Fly  1009 QEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVM----A 1069
                                          |||:   |...:|..||.........||.:    .
  Rat   524 ------------------------------QVIL---CGTCLIVSSVKDSSSGKMHVLPLIGGKV 555

  Fly  1070 EEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMV 1134
            ||......||..:|:    ..|.:|.:||                      ..|..|:.|:||.|
  Rat   556 EEVKKHQHCLAFSSS----GPQSQTYYIC----------------------FDTFTEYLRWLRQV 594

  Fly  1135 SPYSN--ISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLN 1197
            |..::  ||..:.......:|.|.:.::              .|:|.......|:|.
  Rat   595 SKVASQRISSVDLSCCSLEHLPANLFYS--------------QDLTHLNLKQNFLRQ-------- 637

  Fly  1198 LTPPLPQSHRPYTLT--TNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYL-VFTWVLCLVSLA 1259
             .|.||.:.....|.  |...|::|||                      .:| .|...:|  |:.
  Rat   638 -NPSLPAARGLGELQRFTKLKSLNLSN----------------------NHLGAFPSAVC--SIP 677

  Fly  1260 TALKLYYLVKALMAL-----AMVAFYTTLI---MMKFGSGDSFSLVELSRLGMPLG----VQMLI 1312
            |..:|.....||..:     ||....|.|:   .::....:..::.:||.||:...    :..::
  Rat   678 TLAELNVSCNALREVPAAVGAMQNLQTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPEVL 742

  Fly  1313 LLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKS-NRALNDTLIKNILPD------HVAT 1370
            ..::.:..:|.....:| |.||      ||.|.:.::|. :..||  :::.::.|      ||..
  Rat   743 EKLTAVDKLCMAGNCME-TLRL------QALRRMPHIKHVDLRLN--ILRKLITDEVDFLQHVTQ 798

  Fly  1371 YYLSDEHTDEL-------YSKMH---------NLCG----VMFAS-----------IPNFQDFYS 1404
            ..|.|....:|       ...:|         |:||    .::||           :||:..:
  Rat   799 LDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKALYASSNELVQLDVYPVPNYLSY-- 861

  Fly  1405 EDIDNGKACIRILNEIICD----------FDELLEEPR----FASVEKIKTVGATYMAAAGLNHE 1455
              :|..:.|:..:.|.:|:          .:::.|.|.    .:|:.|:         .||  |.
  Rat   862 --MDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKL---------LAG--HN 913

  Fly  1456 HL-RLRGETSEDSV--------------------CDLVEFAFAMKQKLE--------EINGDAFN 1491
            .| ||.......||                    .|.:.|..|...|||        |.......
  Rat   914 RLARLPERLERTSVEVLDVQHNQIIELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQ 978

  Fly  1492 NFQLRVGICSG---PLVSGVIGARKPVYDIWGNTVN--VASRMDSTGENWRVQVPEN------TA 1545
            ...|.....:.   ||::|  ..|..:..:..|.:.  .||:|....|...:.:..|      |.
  Rat   979 ELYLTNNSLTDKCVPLLTG--HPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTT 1041

  Fly  1546 ELLCSRGYTCVKRGEI--------------AVKGKGMMT-TFYVHP-----KGISESQLISPVRM 1590
            .:.|.|.:|.:.....              :.:|.|.:: :.::.|     ..:|.::| |.:.:
  Rat  1042 IMNCRRMHTVIAHSNCIEVFPEVMQLPEVKSTEGNGSLSRSSFLFPLFHQCVDLSCNEL-SEITL 1105

  Fly  1591 PAGIPLAQTPNLQ--------RQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRG 1647
            |..:|    |.||        |....|.|..  :...::..|.....||..:|.|:.. ..|:..
  Rat  1106 PENLP----PKLQELDLTGNPRLALDHKSLE--LLNNIRCFKIDQPSAGDASGAPAVW-SHGYTE 1163

  Fly  1648 STFSSVRLSQKSTTVNPVRRNTTRVRG 1674
            ::....:|...:.:||..|.|...:.|
  Rat  1164 ASGVKNKLCVAALSVNNFRDNREALYG 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888	19/136 (14%)
		CYCc	1353..1554	CDD:214485	53/291 (18%)
		Guanylate_cyc	1381..1576	CDD:278633	49/294 (17%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021	17/108 (16%)
		RA_PHLPP1	<424..491	CDD:340760	10/66 (15%)
		PH_PHLPP-like	498..594	CDD:270131	29/159 (18%)
		PLN00113	602..>1109	CDD:215061	103/580 (18%)
		leucine-rich repeat	604..624	CDD:275380	2/33 (6%)
		leucine-rich repeat	625..655	CDD:275380	7/38 (18%)
		leucine-rich repeat	679..701	CDD:275380	5/21 (24%)
		leucine-rich repeat	702..724	CDD:275380	2/21 (10%)
		leucine-rich repeat	725..771	CDD:275380	12/52 (23%)
		leucine-rich repeat	772..795	CDD:275380	4/24 (17%)
		leucine-rich repeat	796..816	CDD:275380	4/19 (21%)
		leucine-rich repeat	817..858	CDD:275380	7/40 (18%)
		leucine-rich repeat	859..881	CDD:275380	4/25 (16%)
		leucine-rich repeat	882..904	CDD:275380	2/21 (10%)
		leucine-rich repeat	905..926	CDD:275380	7/31 (23%)
		leucine-rich repeat	927..950	CDD:275380	1/22 (5%)
		leucine-rich repeat	951..974	CDD:275380	6/22 (27%)
		leucine-rich repeat	977..1000	CDD:275380	4/24 (17%)
		leucine-rich repeat	1001..1024	CDD:275380	4/22 (18%)
		leucine-rich repeat	1067..1112	CDD:275380	8/49 (16%)
		PP2Cc	1151..1403	CDD:214625	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900