DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and npr3

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio

Alignment Length:	457	Identity:	89/457 - (19%)
Similarity:	148/457 - (32%)	Gaps:	163/457 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 HLAVITIIKLQHGEATINPECVLFQ-IFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEH 520
            ||..|....|:..|.        || ||.:|...||      |..|..|:.:|..:.
Zfish   140 HLTRIAPTYLKMAET--------FQAIFGHFGWRTA------YLIYDDDKDERNCYF-------- 182

  Fly   521 KKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFT 585
                      |.:.:.::|         ||.:..||..| ...|:..|.|...::.::.     :
Zfish   183 ----------TMEGVFTVL---------SEYHISTDFAV-LNSNEERVDPDGIITSVYG-----S 222

  Fly   586 ELASKTSAQQLVKILNDLFARFDRIAEDNHC-LRVKLLGDCYYCVSQFESDNWK----------- 638
            |:....|...:|:.|. |.|...::..|:|. ..::|...     |.:...:|:
Zfish   223 EVVIMCSKADIVRDLM-LAAHRRKLTSDSHIFFNIELFNS-----SSYGDGSWRRRDKYDDEARA 281

  Fly   639 -------------TRPDHAVCSVETGLHMIKAIKDVRLHTHVD---LNMRI-GIHSGSVMCGVLG 686
                         |:|:....|:|    |.|:::...:....|   :||.: |.|...::..:..
Zfish   282 AYSFLNTVTLLRSTKPEFEDFSIE----MKKSLQQSNIPICEDCSAVNMFMEGFHDALLLYAIAL 342

  Fly   687 NKKWHFDVWSNDVIIANHME---------SGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHL 742
            .     :|.|..:...|.:|         ..||.|:|.:         ||       .|.|:...
Zfish   343 R-----EVKSKGLTKKNGLEITHSMWNRTFEGIAGQVSL---------DA-------NGDRNGDF 386

  Fly   743 KMLNVKTYLIKRTEPLRPKRR-----FGTRSSAH-LAG------SVATAAPPCATPTALPKSISA 795
            .       :::.|:|...|..     |||..|.. |.|      |:.|..||      .|...|:
Zfish   387 S-------VVRMTDPESGKHETVMNYFGTNGSFQILPGFKREWFSLRTIPPP------KPLDPSS 438

  Fly   796 SGSG-------SIGGVTATG----------NDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKN 843
            .|.|       .:||:..|.          |...:|:.|:|.....|.    :..||.:...:.|
Zfish   439 GGLGVSAVTGIIVGGILGTALLLAFYFFRKNYRITIERRTLREECDIG----KHRQLREDSIRSN 499

  Fly   844 IS 845
            .|
Zfish   500 FS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	19/94 (20%)
		CYCc	526..729	CDD:214485	42/240 (18%)
		Guanylate_cyc	566..753	CDD:278633	36/224 (16%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	67/360 (19%)
		ANF_receptor	46..389	CDD:279440	60/333 (18%)
		TM_EphA1	436..468	CDD:214014	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900