DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and adcy7

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	1342	Identity:	406/1342 - (30%)
Similarity:	627/1342 - (46%)	Gaps:	325/1342 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 KQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSV 372
            ||.:|.|.:...:..::...|:.:::|.....:||.|.:.::....|                 :
Zfish    15 KQEALYRKFSGISQYRQFVLLLGLSIVTCATLLVLFFSFKLKAQNHG-----------------I 62

  Fly   373 CCGIANMAIC-FLGYWRCFANNYLHWAAVCT------WVLFNIQGFVGQGV-------GF----- 418
            ..|:...|:| ||..          :..|||      |     :..:|.||       ||
Zfish    63 FVGVVGGALCLFLAV----------FVLVCTETLSQRW-----RTLLGLGVWATHLTMGFTFIFS 112

  Fly   419 --ADREYLVW----YILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPEC 477
              :|.:...|    :.||:|...|.|||..:.:.|:...|::..|:.|:::. |...:...||
Zfish   113 TKSDLQIQPWDQVPFFLFIIITVYTMLPFQMSYAVILSIISSLSHIIVLSVY-LTVAQLHSNP-- 174

  Fly   478 VLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNI 542
            :.||:.:|.:::....:.|::.|.|.::..:..|.:|.:.:..:.:.|.|.::.:.||.|:||..
Zfish   175 ITFQLLSNAVVFGCGIMVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVY 239

  Fly   543 VNNQIR---SEMYKGTDP------TVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVK 598
            ::.:::   .|..|..|.      ..:..|:.|||...:|||||:|||.|||.|||..|.::||.
Zfish   240 ISMKMKLAIMERCKCKDKEEQQRMVRDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVL 304

  Fly   599 ILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRL 663
            :||:||.:||:||::|.|:|:|:|||||||||...    .:.|:||...|:.||.|.:|||.||.
Zfish   305 MLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP----VSLPNHAKNCVKMGLDMCEAIKQVRE 365

  Fly   664 HTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAY 728
            .|.||:|||:|:|||:|:|||:|.:||.|||||:||.:||||||||:||||||:|||||.||.||
Zfish   366 ATGVDINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKAY 430

  Fly   729 EVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSI 793
            |||.|||..||.:||.||:||:|:     :.|:    ::.|:.:|.|:.             |..
Zfish   431 EVEEGNGHLRDTYLKELNIKTFLV-----IDPR----SKDSSLMAPSIT-------------KPR 473

  Fly   794 SASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAM 858
            .:.|......|..|         |.||     :..|.:|...||.:::.|  .:::.|
Zfish   474 VSDGLKMRASVRMT---------RFLE-----SWGAVKPFAHLQSREEFN--TDAMVN------- 515

  Fly   859 DSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLR--PRNGACSIQNLAEAID 921
                                 |.|.|               .::.||  |.:...|.
Zfish   516 ---------------------GKGHC---------------KDIPLRSVPTHNPDSF-------- 536

  Fly   922 GKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNI-Q 985
                   |||.     |.||.....|....||..|  ..||         .|||:.:.:...| .
Zfish   537 -------DESL-----EEPFSLPAPPLSTYNRNKS--QKTK---------FDEELHDKMTTTIND 578

  Fly   986 INSNKE-IRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRL 1049
            ::|:|: ::.|.::..||.|..|..|.::..:....|:..:.|...|:|.:.:.|:::    |:.
Zfish   579 LSSSKQWVKSEEISGLTLWFTKKDLEMQYRTIEMPNFKYYIGCATFIFICIFIIQMLV----TKQ 639

  Fly  1050 IICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVL 1114
            .|.|.:|..:|  .|.|:                                            |:|
Zfish   640 RIELGLGFAVL--ACFLL--------------------------------------------LIL 658

  Fly  1115 CPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITS 1179
            |     |..||...|            |..::.|...:|.|.  ....:..|
Zfish   659 C-----ICFADHIQR------------MFPEKLKSCTWLLAL--SKAVVKRP------------- 691

  Fly  1180 SGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHP 1244
                  |||..|..:...:...:.........|.|     |.:|...::|...|:.|   :..:.
Zfish   692 ------FVRILLATVATTVIVVIAMFELFLKKTDN-----LCDLLQQNSSFADSARD---ELQYL 742

  Fly  1245 EYLVFTWVLCLVSLATALKLYYLVKA--LMALAMVAF-------------YTTLIMMKFGSGDSF 1294
            .|||:..:|.|::....|::.:.:|.  |:.:::|::             |..|:......|||.
Zfish   743 PYLVYNCILALIACGVFLRVSFELKLAFLLIVSLVSYTIILYSQENLFSNYNCLLYTNHSCGDSL 807

  Fly  1295 SLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQ--AERELTNMKSNRALND 1357
            .:.:...:..| .:...|.:..||..:...:|..|...|.||:.|.:  |::|...:..|  ||.
Zfish   808 MVCKAGLMKHP-KIMSCIYITLFLFTMLLISRQNEYCCRQDFLLKNKNLADKEEVELCEN--LNR 869

  Fly  1358 TLIKNILPDHVATYYLSDEHTDE----------------LYSKMHNLCGVMFASIPNFQDFYSE- 1405
            .|::|:||.|||..::.:...:|                ||.|.::...|||||:|:|::||:|
Zfish   870 LLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFASVPDFKEFYTEC 934

  Fly  1406 DID-NGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN--HEHLRLRGETSEDS 1467
            ||: .|..|:|:|||||.||||||.:|:|:.||||||:|:||||||||:  .|......|.....
Zfish   935 DINKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSGPPEQSNQDRERQNAQ 999

  Fly  1468 VCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDST 1532
            :.::||||.|:..||:.||..:||.|:|||||..||:::||||||||.||||||||||||||:||
Zfish  1000 IGNMVEFAIALIGKLDGINRHSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMEST 1064

  Fly  1533 GENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYV 1574
            ||..::||.|.|:.:|.:.||:|..||.|.|||||.:.||:|
Zfish  1065 GELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFV 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	55/270 (20%)
		CYCc	526..729	CDD:214485	109/211 (52%)
		Guanylate_cyc	566..753	CDD:278633	115/186 (62%)
		DUF1053	929..1020	CDD:283888	24/92 (26%)
		CYCc	1353..1554	CDD:214485	109/220 (50%)
		Guanylate_cyc	1381..1576	CDD:278633	112/198 (57%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	29/121 (24%)
		Guanylate_cyc	272..455	CDD:306677	115/191 (60%)
		DUF1053	487..613	CDD:310728	41/215 (19%)
		Guanylate_cyc	909..1106	CDD:306677	111/196 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710