Protein Alignment Ac78C and adcy5

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_001165056.1
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1474
• Identity: 433/1474 - (29%)
• Similarity: 663/1474 - (44%)
• Gaps: 382/1474 - (25%)

  Fly   181 PGDGA--------------QMEDNGSGDLPPSLRASTTSIL-SNLR-KKQQGGPLRGGVAKQTPL 229
            ||.||              :.|...:| .|.|.|:|...:: ||.| ::......:.|.|..|..
Zfish    10 PGAGAPGLRGGTEHRSAWGESESVANG-CPYSARSSCKKLIRSNSRWREDDDFERQPGRATTTVS 73

  Fly   230 RVQSVRIVEAKRAYGPKRRTESCSI-------FGNSNFEHDLESGNSLASIPGQSQRPLNNEMYS 287
            || |.|...|.:..|.:.|..:.|.       ....:.|..||...: .|.|.:...|..|...|
Zfish    74 RV-SFRSKSAWQEQGEESRNNNRSSPRYRDGEVRPKSVELGLEDRRT-KSKPEEELMPEVNFSMS 136

  Fly   288 AFKSGNVVKGILCPSL-----TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVW 346
            |          .|.|:     :..|:...|||.|..|..|..|.|| :::.|:..|..::|.|..
Zfish   137 A----------CCNSVMQIFRSKKFQSEKLERLYQRYFFRLNQSSLTMLMAVLVLVCAVMLGFHC 191

  Fly   347 IMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLH----WAAVCTWVLFN 407
            .....:|         :.....|.::...:..|.:|        ..|..|    | .||..::..
Zfish   192 AGGMCQL---------TFVLVFTAAIVLILTLMVVC--------NRNSFHQDHMW-IVCYLLILL 238

  Fly   408 IQGFVGQGVGFADREYL---VWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHG 469
            :......||.|......   :|:.:|.|.|.|.:||:.::..|:.|.|.::.|:.:
Zfish   239 VLAVQVVGVLFVKPRSASEGIWWTVFFIHVIYTLLPVRMRAAVITGIILSAIHVLI--------- 294

  Fly   470 EATINPECVLF--QIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQ 532
            ...:|...|..  |:.:|.::::..|:.|:.|.|..:..||.||.||.:.::.:..|::|.|:.:
Zfish   295 SWRLNDMDVFLWKQLVSNVLIFSCSNIVGVCTHYPAEGSQRQAFQETRECIQARLHSQRENQQQE 359

  Fly   533 KLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLV 597
            :||.|:||..|..::::::....:   :..|:|:|:...||||||||||:|||.|||:.:||:||
Zfish   360 RLLLSVLPRHVALEMKADINAKQE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELV 421

  Fly   598 KILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVR 662
            ..||:||||||::|.:|||||:|:|||||||||...    :.|.|||.|.||.|:.||:||..||
Zfish   422 MTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVEMGVDMIEAISLVR 482

  Fly   663 LHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDA 727
            ..|.|::|||:|||||.|.|||||.:||.||||||||.:|||||:||..||:||::|||..||..
Zfish   483 EVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGD 547

  Fly   728 YEVEPGNGGCRDNHLKMLNVKTYLI-----KRTEP---LRPKRRFGTRSSAHLAGSVATAAPPCA 784
            |:||||:||.|:.:||..|::||||     ||.|.   :....|..|.|..|
Zfish   548 YDVEPGSGGERNVYLKKHNIETYLIVGCSQKRKEEKAMIAKMNRQRTNSVTH------------- 599

  Fly   785 TPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSL 849
                                                          ..|....:....:::.||
Zfish   600 ----------------------------------------------NSTHWTDRPFYNHLNANS- 617

  Fly   850 PNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQ 914
                  |:.:.:|:               |...|
Zfish   618 ------VSKEMKRM---------------GFEDP------------------------------- 630

  Fly   915 NLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEF 979
                         :|::|.:        ||| |||                         |:|||
Zfish   631 -------------KDKNTQE--------NLN-PED-------------------------EVDEF 648

  Fly   980 IEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIP 1044
            :.:.|...|...:|.|::..:.|.|::...|:|:.:..:..|.:.:.|..::::|:...|:||:|
Zfish   649 LGRAIDARSIDRLRSEHVKKFLLTFREPDLEKKYSKQVDSSFGAYVACASLVFLFICFIQIIIVP 713

  Fly  1045 RCTRL----IICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMC 1105
            ....:    ::||.|..|::....:......|| :|  |:|.|.::|..|...||.....||.:.
Zfish   714 HSGLMVGFYVLCLVVLMVVMFISAIYSCFGFFP-IP--LQTLSKRIVQSRLNSTLVGVFTIVLVF 775

  Fly  1106 MLSAIGLVLCPS---STYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPA 1167
            :.:.|.:..|.:   .|.:|  .|.:     :|| ||::.....|
Zfish   776 ISAFINIFTCSTDDLKTCLG--QEFN-----ISP-SNVNACHAHF-------------------- 812

  Fly  1168 SGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQ 1232
                                 |:||                |||             :|...:..
Zfish   813 ---------------------SSLN----------------YTL-------------WSQNRLCN 827

  Fly  1233 SSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLV 1297
            |||..   |..|||.....:|.|::.:..|::..:.|..:.|.:...|  :::|:......|..|
Zfish   828 SSSPT---CNFPEYFSSCVLLSLLACSVFLQVSSIGKLFLMLFIEILY--VLIMEVPEVSLFDNV 887

  Fly  1298 ELSRLG---------------MPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELT 1347
            :|..:.               :||.:...:::..|::.:..||:.||.|:||||:||.||..|..
Zfish   888 DLLVMANALAPNNGTCIVDTRVPLKIVTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKE 952

  Fly  1348 NMKSNRALNDTLIKNILPDHVATYYLSDE-HTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN- 1409
            .|:..:|.|..|:.||||..||.::|:.| ..||||.:......||||||.||.:||.| :.:|
Zfish   953 EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNE 1017

  Fly  1410 GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN--------HEHLRLRGETSED 1466
            |..|:|:|||||.||||::.|.:|..:|||||:|:|||||:|||        ..|:|.
Zfish  1018 GVECLRLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAASGLNDSTYDKAGRSHIRA------- 1075

  Fly  1467 SVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDS 1531
                |.::|..:..:::.||..:||||::::|:..||:|:||||||||.||||||||||||||||
Zfish  1076 ----LADYAMRLMDQMKYINEHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDS 1136

  Fly  1532 TGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575
            ||...|:||..:..::|.|..||...||.:.|||||.|.|::::
Zfish  1137 TGVPERIQVTTDLYQVLSSYNYTLEYRGVVKVKGKGEMMTYFLN 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	63/277 (23%)
		CYCc	526..729	CDD:214485	111/202 (55%)
		Guanylate_cyc	566..753	CDD:278633	116/191 (61%)
		DUF1053	929..1020	CDD:283888	20/90 (22%)
		CYCc	1353..1554	CDD:214485	100/211 (47%)
		Guanylate_cyc	1381..1576	CDD:278633	98/205 (48%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	95/420 (23%)
		CYCc	354..548	CDD:214485	111/200 (56%)
		Guanylate_cyc	390..574	CDD:278633	116/187 (62%)
		DUF1053	598..687	CDD:283888	28/247 (11%)
		CYCc	961..1155	CDD:214485	98/204 (48%)
		Guanylate_cyc	987..1181	CDD:278633	98/205 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710