Protein Alignment Ac78C and adcy6b

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_002666536.2
• Gene: adcy6b / 560807
• ZFINID: ZDB-GENE-090127-2
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1310
• Identity: 390/1310 - (29%)
• Similarity: 620/1310 - (47%)
• Gaps: 315/1310 - (24%)

  Fly   304 TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATA 367
            :..||.:.|||.|..|..|..|.|| :::.|:..|..::|||..:.     ||      ..:|.|
Zfish   136 SKKFKSAKLERLYQRYFFRLNQSSLTMLMGVLVVVCGVMLAFHCVQ-----GP------PDVAYA 189

  Fly   368 ITWSVCCG--IANMAICFLGYWRCFANNYLHW--AAVCTWVLFNIQGFVGQGVGFADREYL---V 425
            ...||..|  :..|.:|   ....|..:|: |  :.:...||..:|.|   |:...|...:   :
Zfish   190 SVLSVAMGLFLTLMVVC---NRNGFHQDYM-WIVSYLVMGVLVVVQVF---GLLMVDPPSMPEGI 247

  Fly   426 WYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLF-QIFANFILY 489
            |:.:|.|::.|.:||:.::..|:.|.:.::.|:.:.....|:        :..|: |:.||.:::
Zfish   248 WWTVFFIYIIYTLLPVRMRAAVITGAVLSTIHIVMAWRFNLE--------DSFLYKQLCANAMIF 304

  Fly   490 TAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKG 554
            ...|:.|:.|.|..:..||.||.||...::.:...::|.|:.::||.|:||..|..::::::...
Zfish   305 LCTNIIGICTHYPAEVSQRQAFKETRGYIQARIHLQRENQQQERLLLSVLPRHVAMEMKADINAK 369

  Fly   555 TDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRV 619
            .:   :..|:|:|:...||||||||||:|||.|||:.:||:||..||:||||||::|.:|||||:
Zfish   370 KE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAWENHCLRI 431

  Fly   620 KLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGV 684
            |:|||||||||...    :.|.|||.|.||.|:.||:||..||..|.|::|||:|||||.|.|||
Zfish   432 KILGDCYYCVSGLP----EPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGV 492

  Fly   685 LGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKT 749
            ||.:||.||||||||.:||.||:||..||:||::|||:.||..||||.|.||.|:.:|...|::|
Zfish   493 LGLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLNGDYEVEAGFGGDRNAYLNNNNIET 557

  Fly   750 YLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASI 814
            :.:           .|                 |:......|::.|.
Zfish   558 FFV-----------LG-----------------CSQKRKEEKAMMAK------------------ 576

  Fly   815 DGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGG 879
                                  .|:.:.|.|        ||
Zfish   577 ----------------------MQRARANSS--------EG------------------------ 587

  Fly   880 GTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNL 944
                                    |.||                           |:|:..|...
Zfish   588 ------------------------LMPR---------------------------WVPDRSFSRT 601

  Fly   945 NSP----EDGLNRADSILVDTKEDHRVSVAVL--DEEIDEFIEQNIQINSNKEIRREYLNPWTLK 1003
            ...    :.|::.|.|      :|:|.:...|  ::|:|||:.:.|...|..::|::::..:.|.
Zfish   602 KDSKVFRQMGIDEASS------KDNRCAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLT 660

  Fly  1004 FKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVIL----TFCC 1064
            |:....|:|:.:..:|.|...:.|..:::.|:|..|::|.|. |.|::.|.:...|:    .|.|
Zfish   661 FQTPLLEKKYSKKVDDRFGGYVACTLLVFCFIVFIQIVIFPH-TPLMLGLFITIFIILAHVLFIC 724

  Fly  1065 VLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSR 1129
            .:....:.  .|..|:|.|.::|..|...||.....|:.:.:.:.:.:..|          :.:.
Zfish   725 AIYSCVKL--FPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFVNMFTC----------DRTD 777

  Fly  1130 FLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNAL 1194
            .|..|:.:.|||.:         ::..:.:|:                  ||.:::
Zfish   778 MLACVAGHLNISES---------VTLCLLYNL------------------SGLAED--------- 806

  Fly  1195 TLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLA 1259
                         |:.|..                      |....|..|||..::.:|.|:..:
Zfish   807 -------------PFFLCL----------------------DQPSACPLPEYFTYSVLLTLLCCS 836

  Fly  1260 TALKLYYLVKALMALAMVAFYTTLI----MMKFGSGDSFSLVEL------------SRLGMPLGV 1308
            ..|.:..:.|.::.|.:...:..||    :....:.|....|:.            :...:.|.|
Zfish   837 VFLHISSIGKLVLMLFIQICFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQETVTKVSLRV 901

  Fly  1309 QMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL 1373
            .:.::|..|::.:..||:.||.|:||||:||.||..|...|:..:|.|..|:.||||..||.::|
Zfish   902 SIPVILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL 966

  Fly  1374 SDE-HTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFAS 1435
            :.| ..||||.:......||||||.||.:||:| :.:| |..|:|:|||||.||||::.|.::..
Zfish   967 ARERRNDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEIIADFDEIISEEKYKQ 1031

  Fly  1436 VEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGIC 1500
            :|||||:|:|||||:|||.......|.|   .:..|.::|..::::::.||..:|||||:::|:.
Zfish  1032 LEKIKTIGSTYMAASGLNDSTYDKEGRT---HILALADYAMRLREQMKYINEHSFNNFQMKIGLN 1093

  Fly  1501 SGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKG 1565
            .||:|:||||||||.||||||||||||||||||...|:||..:...:|.|:||....||.:.|||
Zfish  1094 IGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKGYQLECRGLVKVKG 1158

  Fly  1566 KGMMTTFYVH 1575
            ||.|||::::
Zfish  1159 KGDMTTYFLN 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	66/255 (26%)
		Guanylate_cyc	566..753	CDD:425528	111/186 (60%)
		Adcy_cons_dom	929..1021	CDD:461877	21/97 (22%)
		Guanylate_cyc	1381..1576	CDD:425528	99/197 (50%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	66/268 (25%)
		Guanylate_cyc	378..562	CDD:425528	111/198 (56%)
		Adcy_cons_dom	590..678	CDD:461877	23/120 (19%)
		Guanylate_cyc	975..1169	CDD:425528	99/197 (50%)