DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and npr1a

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	724	Identity:	151/724 - (20%)
Similarity:	282/724 - (38%)	Gaps:	174/724 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   923 KGLIIEDESTTDW--------IPEIPFKNLNSPEDGLNRADSILVDTKEDHR-VSVAV-----LD 973
            |.:|:|......|        |||..|||.|         .:.|..|...|: :|:.|     :.
Zfish   437 KQMILEPGMKVHWLKGRPPPDIPECGFKNDN---------PACLAKTVTMHQMISIVVCFIFIII 492

  Fly   974 EEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLC 1038
            ..:..||.:.:::.:  |:..:.   |.:.:             ||:..||             .
Zfish   493 VTVTVFIYRKLKLEN--ELTAQL---WRVHW-------------EDIQMSN-------------T 526

  Fly  1039 QVIIIPRCTRLIICL---SVGTVILTFCCVLVMAEE--FPGLPRCLKTNSAKLVH---------- 1088
            :.::...|::|.|.|   :.|:::.......:.|:.  :.|....:|..:.|.:.
Zfish   527 EKVLRRACSKLTISLRGSNYGSLLTMDGNFQIYAKTGYYKGNITAIKYVNKKRIELTRKVLFELK 591

  Fly  1089 -----QRQRRTLFICGVI--VSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKE 1146
                 |.:..|.||...|  .::|:|:.    .||..:.....:.....|..:..||.|:...|.
Zfish   592 HMRDVQNEHLTRFIGACIDPPNICILTE----YCPRGSLQDLMESEGITLDWMFRYSLINDIVKG 652

  Fly  1147 FKLNVYLSATIHHNITISTPASGGPTPLVD------ITSSGPSDEFVRSTLN------ALTLNLT 1199
            .       |.:|:::.:|.........:||      ||..|.......|.|:      |..|...
Zfish   653 M-------AFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNLDDVHAFYARQLWTA 710

  Fly  1200 PPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLV-----FTW-----VLC 1254
            |.|.::..|....|....|....:...:.::::....:||.|..|:.::     ..|     :||
Zfish   711 PELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERVVEGRWPYLRPLLC 775

  Fly  1255 LVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGD-----SFSLVE--LSRLGMPLGVQMLI 1312
            ..|.:..:                   ..:|::..|.|     .||.::  |.:.....|..:|.
Zfish   776 PQSHSEEM-------------------GQLMLRCWSEDVNERPDFSQIKVLLRKNNCGYGSNILD 821

  Fly  1313 LLISFLVMVCYHARLVEVTSRLDFIWKE--QAERELTNMKSNRALNDTLIKNILPDHVATYYLSD 1375
            .|:|         |:.:..:.|:.:.:|  ||..|    :..:|  :.|:..|||..||...
Zfish   822 NLLS---------RMEQYANNLEELVEERTQAYHE----EKRKA--EALLYQILPHSVAEQL--- 868

  Fly  1376 EHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIK 1440
            :..:.:.::..:...:.|:.|..|....:|  ......:.:||::...||.:::.   ..|.|::
Zfish   869 KRGEMVQAEAFDSVTIYFSDIVGFTALSAE--STPMEVVTLLNDLYTCFDAIIDN---FDVYKVE 928

  Fly  1441 TVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQ--LRVGICSGP 1503
            |:|..||..:||...:.:|...       ::...:.|:.:.:.........|.|  ||:||.|||
Zfish   929 TIGDAYMVVSGLPVRNGKLHAR-------EIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGP 986

  Fly  1504 LVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVK---RGEIAVKG 1565
            :.:||:|.:.|.|.::|:|||.||||:|.||..::.|.|.|..:|  :.:.|.:   ||::.:||
Zfish   987 VCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVL--QEFNCFQLELRGDVEMKG 1049

  Fly  1566 KGMMTTFYV 1574
            ||.|.|:::
Zfish  1050 KGRMRTYWL 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888	18/104 (17%)
		CYCc	1353..1554	CDD:214485	54/202 (27%)
		Guanylate_cyc	1381..1576	CDD:278633	56/199 (28%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380	3/11 (27%)
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944	51/303 (17%)
		TyrKc	554..808	CDD:197581	48/283 (17%)
		HNOBA	<823..868	CDD:285003	15/59 (25%)
		CYCc	847..1032	CDD:214485	55/207 (27%)
		Guanylate_cyc	874..1060	CDD:278633	56/199 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900