DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and ADCY10

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	1083	Identity:	193/1083 - (17%)
Similarity:	338/1083 - (31%)	Gaps:	388/1083 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 NVAGMYTKYLTDRGQRLAFIETHKAMEHKK----------ESEKELQRTQKLLDSILPNIVNNQI 547
            |....:||..|       |:..:.:.|||.          :.|.|:...:.:::|||..|.|.|:
Human   225 NFDEFFTKCTT-------FMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQL 282

  Fly   548 RSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAE 612
            :.                 |:..:..|:|:|.::.    ...:..|:::...:.|.:.....:.:
Human   283 QG-----------------YLSELRPVTIVFVNLM----FEDQDKAEEIGPAIQDAYMHITSVLK 326

  Fly   613 ------------DNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAV-CSVETGLHMIKAIKDVRLH 664
                        |..|        .:.||..|..:.......||: |:::        |.|....
Human   327 IFQGQINKVFMFDKGC--------SFLCVFGFPGEKVPDELTHALECAMD--------IFDFCSQ 375

  Fly   665 THVDLNMRIGIHSGSVMCGVLGNKKWH-FDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAY 728
            .|....:.||:.||.|.||::|:...| :.|....|.:|..|.. ..||.|.....|.
Human   376 VHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMM-YYPGIVTCDSVTY------- 432

  Fly   729 EVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSI 793
                 ||.         |:..|..|.                                  |||.:
Human   433 -----NGS---------NLPAYFFKE----------------------------------LPKKV 449

  Fly   794 SASGSGSIGGVTATGNDGASIDGRSLEY----------AATIAVPAQQPTQLLQQQQKKNISLNS 848
            .               .|.:..|...:|          .|.:....::...||.:.::.|..:.:
Human   450 M---------------KGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRNKEINYFMYT 499

  Fly   849 LPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSI 913
            :...:         |.|...|:...|..|.|          .|...|                .|
Human   500 MKKFL---------ISNSSQVLMYEGLPGYG----------KSQILM----------------KI 529

  Fly   914 QNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNR--------------ADSILVDTKED 964
            :.||:.                      ||.......||:              |:.:.:||.:.
Human   530 EYLAQG----------------------KNHRIIAISLNKISFHQTFYTIQMFMANVLGLDTCKH 572

  Fly   965 HRVS--------VAVLDEEI-----DEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQL 1016
            ::..        :.:|||:.     |.|   ::|...::||.|..    ||| |.|..|..|.::
Human   573 YKERQTNLRNKVMTLLDEKFYCLLNDIF---HVQFPISREISRMS----TLK-KQKQLEILFMKI 629

  Fly  1017 REDMFRSNMLCVFVI----------WIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEE 1071
            .:.:.:...: :|:|          |.||           .:||..|.: .:|::.|       .
Human   630 LKLIVKEERI-IFIIDEAQFVDSTSWRFM-----------EKLIRTLPI-FIIMSLC-------P 674

  Fly  1072 FPGLPRCLKTNSAKLVHQRQRRTLFICGVIV------SMCMLSAIGLVLCPSSTYIGTAD----- 1125
            |..:| |.   :|:.|.:.:..|..:.|.:.      .:|:...:..:.....:|:|...
Human   675 FVNIP-CA---AARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPF 735

  Fly  1126 ---------EHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSG 1181
                     ||...|       ....||.|.|.|...:....::|.::...:     :|.:.|..
Human   736 YCEELLKNLEHHEVL-------VFQQTESEEKTNRTWNNLFKYSIKLTEKLN-----MVTLHSDK 788

  Fly  1182 PSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEY 1246
            .|:|....|......||:||                .||..:|......|:.|..:..:||....
Human   789 ESEEVCHLTSGVRLKNLSPP----------------TSLKEISLIQLDSMRLSHQMLVRCAAIIG 837

  Fly  1247 LVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSG-----------DSF-----S 1295
            |.||..| |..:.....:..::|.|..|.     .:.|...|.:|           .||     |
Human   838 LTFTTEL-LFEILPCWNMKMMIKTLATLV-----ESNIFYCFRNGKELQKALKQNDPSFEVHYRS 896

  Fly  1296 LVELSRLGMPLGVQMLILLISFLVMVCYHAR----LVEVTSRLDFIW-KEQAERELTNMKSNRAL 1355
            |......||..|.:..:..:...|:.|:..|    :::.|:.  .:| |:|  |:..::|..|.|
Human   897 LSLKPSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAY--ELWLKDQ--RKAMHLKCARFL 957

  Fly  1356 NDTLI-------KNILPDHVATYYLSDEHTD-ELYSKMHNLCG--------VMFASIPNFQDFYS 1404
            .:...       ::.:|.|..|..:.....| :...||....|        :..:.||....|:.
Human   958 EEDAHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFP 1022

  Fly  1405 EDIDNGKACIRILN--------------EII----CDFDELLE 1429
            |:....:...:|||              :||    |..:|:||
Human  1023 ENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILE 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	16/67 (24%)
		CYCc	526..729	CDD:214485	41/216 (19%)
		Guanylate_cyc	566..753	CDD:278633	38/200 (19%)
		DUF1053	929..1020	CDD:283888	23/117 (20%)
		CYCc	1353..1554	CDD:214485	22/111 (20%)
		Guanylate_cyc	1381..1576	CDD:278633	16/75 (21%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	43/259 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900