Protein Alignment Ac78C and adcy1a

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1457
• Identity: 398/1457 - (27%)
• Similarity: 621/1457 - (42%)
• Gaps: 431/1457 - (29%)

  Fly   219 LRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESC----SIFGNSNFEHD-----------LESGN 268
            :.|...::.||.....|..:::...|...|...|    ::|...|.:.:           :.:.:
Zfish     1 MNGPAMEEVPLPRVRTRRRKSRCLAGACERDFDCKELETLFQKYNLKLEQTATLKALAILILAAS 65

  Fly   269 SLASIPGQSQRPLNNEMYSAFKSGNVVKG---ILCPSLTNSFKQSSLERSYLTYTHRQRQKSLII 330
            :||.:          |:.||.....|.||   :.|...|:.|..::::  ||..|..|:
Zfish    66 ALALV----------ELLSAGSRFTVSKGSHPVHCVIFTSLFIVTNVK--YLQVTQLQQ------ 112

  Fly   331 VNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYL 395
                  :.::.|.|                      :.|:::.|....:|   ||:
Zfish   113 ------IARLALLF----------------------SFTFALLCCPFPLA---LGH--------- 137

  Fly   396 HWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAV 460
                       ..||..|........|..||.::.|.||.|::||:.....|:.|.:.|:.|..|
Zfish   138 -----------GTQGTHGPDAPSTTPEQGVWQLMLVTFVAYSLLPVRTLLAVLFGVLVAASHFIV 191

  Fly   461 ITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESE 525
            ...      ..|.....|...:.||.:|...:|::|::.:..|:|.||.||::....::.:.:.|
Zfish   192 TAT------SVTARRPRVWTPLVANAVLLVGVNLSGVFVRVRTERAQRKAFLQARNCIQQRLQLE 250

  Fly   526 KELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASK 590
            .|.::.::||.|:||..|..:::.:..|    ..|..|:|:|:...||||||||||.|||.|||:
Zfish   251 DENEKQERLLMSLLPRNVAMEMKEDFLK----PPERIFHKIYIQRHDNVSILFADIVGFTSLASQ 311

  Fly   591 TSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRP--DHAVCSVETGLH 653
            .:||:|||:||:||.:||.:|.:|||.|:|:|||||||||..      |:|  |||.|.||.||.
Zfish   312 CTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL------TQPKADHAHCCVEMGLD 370

  Fly   654 MIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISE 718
            ||..|..|...|.||||||:|:|:|.|:|||||.:||.:|||||||.:||.||:||:||:|||::
Zfish   371 MIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITK 435

  Fly   719 ATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLI-----KRTEP------LRPKRRFGTRSSAHL 772
            |||:|||..||||||.|..|...|....::|:.|     ::..|      ::|.:|...::..:|
Zfish   436 ATLECLNGDYEVEPGFGHERHAFLSKHAIETFFIVPSHRRKIFPGLILSDIKPAKRMEFKTVCYL 500

  Fly   773 AGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQ 837
                                                                          |:|
Zfish   501 --------------------------------------------------------------LVQ 503

  Fly   838 QQQKKNISLNSLP--NVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPL 900
            ....:.:....:|  ||:.....|.||                               |:.:|..
Zfish   504 LMHCRKMFKAEIPFSNVMTCEDDDKRR-------------------------------ALRTASE 537

  Fly   901 EVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDH 965
            :::.|....|..:|                              |||...:||....|::.::
Zfish   538 KLRNRTSFSAGMVQ------------------------------NSPGTRVNRYIGRLIEARQ-- 570

  Fly   966 RVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFV 1030
                  .:.|:.:                  ||..||.::.:.:||::.|:.:|.|.|.::...|
Zfish   571 ------TESEMAD------------------LNYITLTYRSREREQRYLQVYDDAFISAVVISLV 611

  Fly  1031 IWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAE-------EFPGLPRCLKTNSAKLVH 1088
            :..|..:...:|||:...::|       :|..|....||.       .....|.||..
Zfish   612 LTSFFAVVYFLIIPQGLLVVI-------LLVLCLCFHMASVMYLHVTHVQCSPDCLTL------- 662

  Fly  1089 QRQRRTLFICGVIVSMCMLSAIG-LVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVY 1152
              |.||: :||.:|.:......| :|.|...:..|.              |:|||
Zfish   663 --QIRTV-LCGFLVLLMYSVTQGCVVTCVPWSLEGN--------------SSISM---------- 700

  Fly  1153 LSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHS 1217
                    :|:                                               :|.||..
Zfish   701 --------VTV-----------------------------------------------VTVNGTG 710

  Fly  1218 VSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTT 1282
            |...                  .|.:..|:..:.|:..:|:|..|::..|.|.|:.|.:...: |
Zfish   711 VGYR------------------VCKYTPYVFLSCVMASLSVALYLRVSSLPKILLLLLLNILH-T 756

  Fly  1283 LIMMKFG----SGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAE 1343
            ::|...|    .|..|....        |...::.::.|...:..|.|.:::..|||::|..|||
Zfish   757 VVMETSGYRKAVGGGFFHTH--------GYDPVLAMLLFSGALVLHCRQLDLKLRLDYLWATQAE 813

  Fly  1344 RELTNMKSNRALNDTLIKNILPDHVATYY-LSDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-D 1406
            .|..:|:..:..|..::.|:||.|||.:: ||:....:||.:.::..||:|||||||.|||.| |
Zfish   814 EERDDMERVKLDNKRILFNLLPAHVAQHFLLSNPRNMDLYYQSYSQVGVLFASIPNFNDFYIELD 878

  Fly  1407 IDN-GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSV-- 1468
            .:| |..|:|:|||||.|||.|:::..:..:|||||:|:|||||.||    :...|...:.|:
Zfish   879 GNNMGVECLRLLNEIIADFDALMDKECYRDIEKIKTIGSTYMAAVGL----VPTEGSKVKKSISA 939

  Fly  1469 --CDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDS 1531
              |.:.::|..|...|:.||..::|:|.|||||..||:|:||||||:|.||||||||||||||||
Zfish   940 HLCTVADYAIEMFDVLDAINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDS 1004

  Fly  1532 TGENWRVQVPENTAELLCSRGY---TCVKRGEIAVKGKGMMTTFYVH---PKGISESQLISP--- 1587
            ||...::||.|:...||  .||   .|  ||:::|||||.|.|:::.   |:|...|:..||
Zfish  1005 TGVQGKIQVTEDVFRLL--SGYYDFNC--RGQVSVKGKGQMLTYFLEGRTPQGAQHSRSKSPDQD 1065

  Fly  1588 ----VRMPAG-IPLAQTPNLQRQTSHH 1609
                :|...| .|...:..::..|..|
Zfish  1066 SSPCIRTKLGSAPAVSSYGVKSHTVGH 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	69/349 (20%)
		Guanylate_cyc	566..753	CDD:425528	110/193 (57%)
		Adcy_cons_dom	929..1021	CDD:461877	15/91 (16%)
		Guanylate_cyc	1381..1576	CDD:425528	102/206 (50%)
adcy1a	NP_001161821.1	AcyC	114..449	CDD:441717	151/395 (38%)
		Guanylate_cyc	287..469	CDD:425528	109/187 (58%)
		Adcy_cons_dom	513..602	CDD:461877	26/175 (15%)
		Guanylate_cyc	852..1048	CDD:425528	102/203 (50%)