Protein Alignment Ac78C and npr1b

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_009290669.2
• Gene: npr1b / 555911
• ZFINID: ZDB-GENE-100805-4
• Length: 1070
• Species: Danio rerio
• Alignment Length: 779
• Identity: 167/779 - (21%)
• Similarity: 285/779 - (36%)
• Gaps: 241/779 - (30%)

  Fly    77 REEGEPDERVVLRRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQIT 141
            |..||...:.:..|.. .|...|.|||:             ||:......|.:.|...|.|.||.
Zfish   383 RPSGESVSKRMWNRTY-YGVTGLVQIDE-------------NGDRETDFALWDMADINTGDFQIV 433

  Fly   142 V--NGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRL----PGDGAQMEDNGSGDLP---- 196
            .  |||                         ..:|:.:|.:    ||....|      |:|
Zfish   434 AVYNGT-------------------------QKEMNILPGMAIQWPGGKVPM------DVPTCGF 467

  Fly   197 ----PSLRASTTSILSNL-------------------RKKQQGGPLRGGVAKQTPLRVQSVRIVE 238
                |:.||.|.::...:                   ||.:....|...:.:.:...:|...:.:
Zfish   468 KNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEK 532

  Fly   239 AKRAYGPKRRTESCSIFGNS---------NFEHDLESGNSLASIPG------------------- 275
            |.|:.|.|.   :.|:.|::         ||:...::|....:|..
Zfish   533 ALRSTGSKL---TLSLRGSNYGSLLTTDGNFQVFAKTGYFKGNIVAIKYINRRRVELTRKVLFEL 594

  Fly   276 QSQRPLNNEMYSAFKSGNV------VKGILCP--SLTNSFKQSSLERSY-------------LTY 319
            :..|.:.||..:.|....:      :....||  ||.|..:..|:...:             :.:
Zfish   595 KHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAF 659

  Fly   320 THRQRQKSLIIVN--------VVD--FVLKIV---LAFVWIMRRSELGPIESDDGTSMATAITWS 371
            .|    .|:|:.:        |||  |||||.   |:.:    |:|   .:::|..|......|
Zfish   660 LH----NSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSI----RTE---SDTEDAHSYYARKLW- 712

  Fly   372 VCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYL------------ 424
            :...::.|        .||.........|.::.:...:..:.:||.:.:.:.|
Zfish   713 LAPELSRM--------ECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDLLSPKEIVDRVALG 769

  Fly   425 VWYILFVIFVPYAMLPL-PLKWCVVGGTITASC------------HLAVITIIKLQHGEATINPE 476
            .|        ||....| |.......|.:...|            |::|  :::.|:.|...|
Zfish   770 EW--------PYLRPSLNPQAHSEELGQLMQRCWAEEPSDRPEFSHISV--LLRKQNREHRSN-- 822

  Fly   477 CVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPN 541
                      ||...::....|...|    :.|....|...:|.|:::|       .||..|||:
Zfish   823 ----------ILDNLLSRMEQYANNL----EELVEERTQAYLEEKRKAE-------ALLYQILPH 866

  Fly   542 IVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFAR 606
            .|..|::    :|  .||:.:       ..|:|:|.|:||.|||.|:::::..|:|.:||||:..
Zfish   867 SVAEQLK----RG--ETVQAE-------AFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTC 918

  Fly   607 FDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVD--L 669
            ||.|.::....:|:.:||.|..||.....|.|.   |........|.:::|:|..::....|  |
Zfish   919 FDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKL---HGREIARMSLALLEAVKTFKIRHRPDEQL 980

  Fly   670 NMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLND--AYEVE 731
            .:|||||||.|..||:|.|...:.::.:.|..::.|||.|.|.::|:|.||...|.:  .:::|
Zfish   981 KLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLE 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	74/421 (18%)
		Guanylate_cyc	566..753	CDD:425528	57/170 (34%)
		Adcy_cons_dom	929..1021	CDD:461877
		Guanylate_cyc	1381..1576	CDD:425528
npr1b	XP_009290669.2	Periplasmic_Binding_Protein_type1	50..453	CDD:471960	22/108 (20%)
		PK_GC-A_B	544..818	CDD:270944	50/303 (17%)
		HNOBA	<818..872	CDD:462234	17/76 (22%)
		CYCc	851..1036	CDD:214485	68/207 (33%)