DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy4

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_062158.2	Gene:	Adcy4 / 54223	RGDID:	2034	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	1299	Identity:	393/1299 - (30%)
Similarity:	602/1299 - (46%)	Gaps:	294/1299 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 YLTYTHRQRQKSLIIVNVVDFVLKIVL--AFVWIMRRSELGPIESDDGTSMATAIT----WSVCC 374
            |.||....:|..|:|:.:|..:..||.  |..|...| ||    :.|.:.:.|.:.    :|:..
  Rat    17 YETYYSLSQQYPLLILLLVIVLCAIVALPAVAWASGR-EL----TSDPSFLTTVLCALGGFSLLL 76

  Fly   375 GIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVW----YILFVIFVP 435
            |:|:.......:.|..:.  |.|||:..         :|.|..|.......|    :.||:||..
  Rat    77 GLASREQQLQRWTRPLSG--LIWAALLA---------LGYGFLFTGGVVSAWDQVSFFLFIIFTV 130

  Fly   436 YAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTK 500
            ||||||.::.....|.|::..||.|   :.|..|....:...:|.|:.||.:|:...||.|.|.|
  Rat   131 YAMLPLGMRDAAAAGVISSLSHLLV---LGLYLGWRPESQRDLLPQLAANAVLFLCGNVVGAYHK 192

  Fly   501 YLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY------KGTDPTV 559
            .|.:|..|..|.|...::..::..:.|.:..:.||.||||..:..::::|:.      :.:.|..
  Rat   193 ALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSSRPEN 257

  Fly   560 ETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGD 624
            ...|:.|||.....||:|:|||.|||.|||:.|.::||.:||:||.:||:||:::.|:|:|:|||
  Rat   258 TNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGD 322

  Fly   625 CYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKK 689
            ||||||...    .:.||||:..|..||.|.:||:.:|:.|.||:|||:|:|||||:|||:|.:|
  Rat   323 CYYCVSGLP----LSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQK 383

  Fly   690 WHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKR 754
            |.:||||:||.:|||||:||:||||||:.|||..|..||.||..:...||.:|:.|...|||:
  Rat   384 WQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADMEHRDPYLRELGEPTYLV-- 446

  Fly   755 TEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSL 819
                                         ..|.|..:....:..|.:          :|::|.::
  Rat   447 -----------------------------IDPWAEEEDEKGTERGLL----------SSLEGHTM 472

  Fly   820 EYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGP- 883
            .       |:...|:.|:                                       ..|...|
  Rat   473 R-------PSLLMTRYLE---------------------------------------SWGAAKPF 491

  Fly   884 CGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPE 948
            ..:|.|.|| |..|.||                                    ||..|    ||:
  Rat   492 AHLSHVDSP-ASTSTPL------------------------------------PEKAF----SPQ 515

  Fly   949 DGLNRADSILVDTKEDHRVSVAVLDEEID----EFIEQNIQINSNKEIRR-EYLNPWTLKFKDKS 1008
            ..|:|:.            :...|.:|:|    :|.:...|:||.|:.:: :..|..||.|::|.
  Rat   516 WSLDRSR------------TPRGLHDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYFREKE 568

  Fly  1009 QEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFP 1073
            .|:::.......|:....|.|::::.....|:::..|...|....|: |.:|....:.|...|.
  Rat   569 MEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRPPALATTYSI-TFLLFLLLLFVCFSEH- 631

  Fly  1074 GLPRCLKTNSAKLVHQRQRRTLFIC-----------GVIVSMCMLSAIGLVLCPSSTYIGTADEH 1127
             |.:|:: ...|::|.....::.:.           ..|:.:..::.:.|:..|.|:       .
  Rat   632 -LTKCVQ-KGPKMLHWLPALSVLVATRPGLRVALGTATILLVFTMAVVSLLFLPVSS-------D 687

  Fly  1128 SRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLN 1192
            ..||   :|  |:|              ::..|.:...|||   .||:.|
  Rat   688 CPFL---AP--NVS--------------SVAFNTSWELPAS---LPLISI--------------- 715

  Fly  1193 ALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVS 1257
                           ||::    |...|..||.|  ..:..|.:::            .:|.|:.
  Rat   716 ---------------PYSM----HCCVLGFLSCS--LFLHMSFELK------------LLLLLLW 747

  Fly  1258 LATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVC 1322
            |..:..|:....|.::..::|   .|.....||.... |.|...:|   .:...|...:.||:
  Rat   748 LVASCSLFLHSHAWLSDCLIA---RLYQGSLGSRPGV-LKEPKLMG---AIYFFIFFFTLLVL-- 803

  Fly  1323 YHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL-SDEHTDELYSKMH 1386
              ||..|...||||:||::..:|....::...|...|::|:||.|||..:: .:...::||.:.:
  Rat   804 --ARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSY 866

  Fly  1387 NLCGVMFASIPNFQDFYSEDIDN--GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAA 1449
            ....|:|||||:|::||||...|  |..|:|:|||||.||||||.:|:|:.||||||:|:|||||
  Rat   867 ECVCVLFASIPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAA 931

  Fly  1450 AGLN---HEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGA 1511
            .|||   .:..:...|.|...:..:||||.|:..||..||..:||||:||||:..||:|:|||||
  Rat   932 TGLNATPGQDTQQDAERSCSHLGTMVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGA 996

  Fly  1512 RKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575
            :||.||||||||||||||:|||...::||.|.||..|.|.||||..||.|.|||||.:.|::::
  Rat   997 QKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGVIKVKGKGQLCTYFLN 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	67/244 (27%)
		CYCc	526..729	CDD:214485	101/208 (49%)
		Guanylate_cyc	566..753	CDD:278633	101/186 (54%)
		DUF1053	929..1020	CDD:283888	21/95 (22%)
		CYCc	1353..1554	CDD:214485	107/206 (52%)
		Guanylate_cyc	1381..1576	CDD:278633	111/200 (56%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831	41/133 (31%)
		CYCc	219..422	CDD:214485	100/206 (49%)
		Guanylate_cyc	264..430	CDD:278633	94/169 (56%)
		DUF1053	479..580	CDD:283888	33/192 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..523		13/77 (17%)
		CYCc	824..1039	CDD:214485	108/214 (50%)
		Guanylate_cyc	861..1060	CDD:278633	111/198 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710