DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	261	Identity:	74/261 - (28%)
Similarity:	130/261 - (49%)	Gaps:	52/261 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1329 EVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMF 1393
            ::|..|: |..::.:..|..::..:...|||:.::||..||...   .|...:.:|.::...::|
Mouse   364 KLTQELE-ILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANEL---RHKRPVPAKRYDNVTILF 424

  Fly  1394 ASIPNFQDFYSEDIDNGKACIRI---LNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNH- 1454
            :.|..|..|.|:.. :|:..::|   ||::...||.|.:..:...|.|::|||..||..:||..
Mouse   425 SGIVGFNAFCSKHA-SGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEP 488

  Fly  1455 --EHLRLRGETSEDSVC----DLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARK 1513
              .|.|        |:|    |::|.|..:     :::|:   :.|:.:||.:|.:|:||||.|.
Mouse   489 CIHHAR--------SICHLALDMMEIAGQV-----QVDGE---SVQITIGIHTGEVVTGVIGQRM 537

  Fly  1514 PVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCV-------------KRGEIAVKG 1565
            |.|.::|||||:.||.::|||..::.|.|.|        |.|:             .||.:::||
Mouse   538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYT--------YRCLMSPENSDPLFHLEHRGPVSMKG 594

  Fly  1566 K 1566
            |
Mouse   595 K 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	63/210 (30%)
		Guanylate_cyc	1381..1576	CDD:278633	62/209 (30%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572
		HNOBA	207..406	CDD:311573	11/42 (26%)
		Guanylate_cyc	412..605	CDD:306677	62/209 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900