DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	1272	Identity:	225/1272 - (17%)
Similarity:	397/1272 - (31%)	Gaps:	426/1272 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 PGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGT--------- 766
            ||.:.:.:..:|        ..|:..|                    |..:.|||:
  Rat    26 PGGIRVLKRNMK--------HNGSRNC--------------------LNRRSRFGSRERDWLRED 62

  Fly   767 --RSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASI----DGRSLEY---- 821
              |...:|.|:..|.|....|.:: ..|.|:|.|..:..|..|....||.    :||...|
  Rat    63 VKRGCVYLYGADTTTATTTTTSSS-SSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLH 126

  Fly   822 --AATIAVPAQQPTQLLQ--------------QQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVM 870
              ......|.::|.|::.              |::..|..|:.:....
  Rat   127 GDLVRRLEPTERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFY----------------- 174

  Fly   871 GGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAE---AIDGKGLIIEDEST 932
                     |..||.|..:.  ..::|....|    |.|...:...||   .:.|..||:  .|.
  Rat   175 ---------GEKPCQMDHLD--RILLSGIYNV----RKGKTQLHKWAERLVVLCGTCLIV--SSV 222

  Fly   933 TDW-------IP----------------------------EIPFKNLNSPEDGLNRADSILVDTK 962
            .|.       :|                            .:.|:.|...:....:|..::
  Rat   223 KDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVV---- 283

  Fly   963 EDHRVSVAVLD----EEIDE--FIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQ--------KF 1013
             ..|:|...|.    ||:.|  |..|:|          .|||   |:......|:        ||
  Rat   284 -SQRISTVDLSCYSLEEVPEHLFYSQDI----------TYLN---LRHNFMQLERPGGLDTLYKF 334

  Fly  1014 CQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRL-IIC-------------LSVGTVILTFCC 1064
            .||:......|.|.:|.:    :||::..:   |.| :.|             |::.|:.|....
  Rat   335 SQLKGLNLSHNKLGLFPV----LLCEISTL---TELNLSCNGFHDLPSQIGNLLNLQTLCLDGNV 392

  Fly  1065 VLVMAEE----------------FPGLPRCLK--TNSAKLVHQRQRRTLFICGVIVSMCMLSAIG 1111
            :..:.:|                |..:|..|:  |...|:|....|..:...||:..|..:..:.
  Rat   393 LTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVD 457

  Fly  1112 LVLCPSSTYIGTADEHSRFLRMVSPYSNISMTE-------------------KEFKLNVYLSATI 1157
            |.:....|.|....|.::.:..:....| .:|:                   :|..|:.:....:
  Rat   458 LRMNHLKTVIIENLEGNKHITHMDLRDN-QLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNL 521

  Fly  1158 HHNITISTPASGGPTP---------------LVDITSSGPSDEFVRSTLNALT------------ 1195
            :.|....|..:..|.|               :.|........|.:..:.|.||
  Rat   522 YANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSL 586

  Fly  1196 ---------LNLTPPLPQSHRPYTLTTNGHSVSLS-----------NLSYSDASVMQSSSDVEGQ 1240
                     :::.|.|.: |.|..:....|: :||           ||.|.:||. .|...:...
  Rat   587 RKLMVGHNHIHVLPALVE-HIPLEVLDVQHN-TLSRLPDTLFSKALNLRYLNASA-NSLESLPSA 648

  Fly  1241 CAHPEYLVFTWVLCLVSLATALKLYYLVKALM---ALAMVAFYTTLIMMKFGSG--DSF------ 1294
            ||..|.|            :.|:|.||...|:   .:.::..:..|.::...:.  .:|
  Rat   649 CAGEESL------------SVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLN 701

  Fly  1295 ---SLVELSRLGMPL-GVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRAL 1355
               .|.||:..|..| .:...|.....|..:..||..:.:...:    .:..:.:..::..| .|
  Rat   702 KLEQLEELNLSGNKLKAIPTTIANCKRLHTLVAHANNISIFPEI----LQLPQIQFVDLSCN-DL 761

  Fly  1356 NDTLIKNILP------------------------DHVATYYLSDE---HTD-------------E 1380
            .:.||...||                        .|:.|..:..:   .||             |
  Rat   762 TEILIPETLPATLQDLDLTGNTNLVLEHKTLDMFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAE 826

  Fly  1381 LYSKMHNLCGVMFASIPNFQD-----FYSEDIDNGKACIRILNEIICDF-DELLEEPRFASVEKI 1439
            :..:.:.|| |...::.||.:     :...|.|..:...|:|.   |.. |.||||.:.::.:.:
  Rat   827 MAGQRNKLC-VSALAMDNFAEGVGAVYGMFDGDRNEELPRLLQ---CTMADVLLEEVQHSTSDTV 887

  Fly  1440 KTVGATYMAAAGL-NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQL---RVGIC 1500
                  :||...| :|..|.:.|:....|         |:...:.....|..::|.|   .||.|
  Rat   888 ------FMANTFLVSHRKLGMAGQKLGSS---------ALLCYIRPDTADPTSSFSLTVANVGTC 937

  Fly  1501 SGPLVSGVIGARKPVYDIWG--NTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAV 1563
            ...|..|  |...|:..::.  :....|.|:    ::.:..:.|:..    ..|.||..|
  Rat   938 QAVLCRG--GKPVPLSKVFSLEHDPEEAQRV----KDQKAIITEDNK----VNGVTCCTR----- 987

  Fly  1564 KGKGMMTTFYVHPKGISESQLIS-PVRMPAGIPLAQTPNLQRQTSHHGSFSAV--VFGMLQASKR 1625
                |:...|::|..:.:..:.| |:.:...:.:.....|....|:..:.|||  |...|.|:|:
  Rat   988 ----MLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQDPLAAAKK 1048

  Fly  1626 STAIAGT-----PTGTPSPQIRRGHRGSTFSSVRLS-------QKSTTVNPVRRNTTRVRGRSYR 1678
            ...:|.:     ..|.....:..|..|.|.....|:       ..:.|:....:.||
  Rat  1049 LCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMHGLALPGPVGFASTATIKDAPKPTT-------- 1105

  Fly  1679 QKKSSSNNSIVTQASSSYMPSFRRIDQIETTISKSHN 1715
               .||::.|.::.||....| ....::.:|.|..||
  Rat  1106 ---PSSSSGIASELSSEVSTS-EVSSEVGSTASDEHN 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485	3/17 (18%)
		Guanylate_cyc	566..753	CDD:278633	5/41 (12%)
		DUF1053	929..1020	CDD:283888	24/139 (17%)
		CYCc	1353..1554	CDD:214485	47/252 (19%)
		Guanylate_cyc	1381..1576	CDD:278633	42/206 (20%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	23/138 (17%)
		PH_PHLPP-like	185..279	CDD:270131	14/101 (14%)
		PLN00113	284..>762	CDD:215061	91/518 (18%)
		leucine-rich repeat	289..309	CDD:275380	5/19 (26%)
		leucine-rich repeat	310..336	CDD:275380	8/38 (21%)
		leucine-rich repeat	337..359	CDD:275380	6/25 (24%)
		leucine-rich repeat	360..382	CDD:275380	3/24 (13%)
		leucine-rich repeat	383..405	CDD:275380	3/21 (14%)
		leucine-rich repeat	406..428	CDD:275380	3/21 (14%)
		leucine-rich repeat	429..452	CDD:275380	6/22 (27%)
		leucine-rich repeat	453..476	CDD:275380	4/22 (18%)
		leucine-rich repeat	477..497	CDD:275380	2/20 (10%)
		leucine-rich repeat	498..517	CDD:275380	2/18 (11%)
		leucine-rich repeat	518..539	CDD:275380	4/20 (20%)
		leucine-rich repeat	540..562	CDD:275380	1/21 (5%)
		leucine-rich repeat	563..584	CDD:275380	4/20 (20%)
		leucine-rich repeat	586..607	CDD:275380	3/21 (14%)
		leucine-rich repeat	608..631	CDD:275380	3/23 (13%)
		leucine-rich repeat	632..681	CDD:275380	14/61 (23%)
		leucine-rich repeat	682..705	CDD:275380	2/22 (9%)
		leucine-rich repeat	706..728	CDD:275380	6/21 (29%)
		leucine-rich repeat	751..772	CDD:275380	5/21 (24%)
		PP2Cc	820..1069	CDD:238083	57/286 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900