DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1432	Identity:	406/1432 - (28%)
Similarity:	614/1432 - (42%)	Gaps:	415/1432 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 ESGNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQ---- 325
            :.|...|..||.::|.........|::..  :...||         .||..:..||.|..|
Mouse     8 QGGGGGAGEPGGAERAAGPGGRRGFRACG--EEFACP---------ELEALFRGYTLRLEQAATL 61

  Fly   326 KSLIIVNV--------------------------VDFVLKIVLAFVWIMRRSELGPIESDDGTSM 364
            |:|.::::                          |..:|.:.|..|..:|..::..::.....::
Mouse    62 KALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFLALFVVTNVRSLQVSQLQQVGQLAL 126

  Fly   365 ATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFN-IQGFVGQGVGFADREYLVWYI 428
            ..::|:::.|                          |.:.|.. .:...|..:|....|..||.:
Mouse   127 FFSLTFALLC--------------------------CPFALGGPARSSAGGAMGSTVAEQGVWQL 165

  Fly   429 LFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITII---KLQHGEATINPECVLFQIFANFILYT 490
            |.|.||.||:||:.....:..|.:.|:.||.|...:   |......|:.         ||.:|:.
Mouse   166 LLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLG---------ANALLFF 221

  Fly   491 AINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGT 555
            .:|:.|::.:.||:|.||.||::....:|.:...|.|.::.::||.|:||..|..:::.:..|
Mouse   222 GVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLK-- 284

  Fly   556 DPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVK 620
              ..|..|:|:|:...||||||||||.|||.|||:.:||:|||:||:||.:||.:|.:|||.|:|
Mouse   285 --PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIK 347

  Fly   621 LLGDCYYCVSQFESDNWKTRP--DHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCG 683
            :|||||||||..      |:|  |||.|.||.||.||..|..|...|.||||||:|:|:|.|:||
Mouse   348 ILGDCYYCVSGL------TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCG 406

  Fly   684 VLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVK 748
            |||.:||.:|||||||.:||.||:.|:||:|||::.||.|||..||||||:|..|:..|:..|::
Mouse   407 VLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIE 471

  Fly   749 TYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGAS 813
            |:.|
Mouse   472 TFFI------------------------------------------------------------- 475

  Fly   814 IDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGG 878
                         ||:          .::.|    .|.::......::|::
Mouse   476 -------------VPS----------HRRKI----FPGLILSDIKPAKRMK-------------- 499

  Fly   879 GGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKN 943
                   ..||        ..|.|||      ...:.:.:|                  ||||.|
Mouse   500 -------FKTV--------CYLLVQL------MHCRKMFKA------------------EIPFSN 525

  Fly   944 LNSPEDGLNRADSILVDTKEDHRVSVA------VLDEEIDEFIEQNIQINSNKEIRREYLNPWTL 1002
            :.:.||...|........|..:|.|.:      .....::.:|.:.::.... |:....||.:||
Mouse   526 VMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQT-ELEMADLNFFTL 589

  Fly  1003 KFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLV 1067
            |:|...:|||:.||:::.|.|.::...::.....|..:::||:...:::.|......|..|.:.:
Mouse   590 KYKHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYL 654

  Fly  1068 MAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLR 1132
            ........|.||      .:..|....:||..:|.|:.....:|.:
Mouse   655 HITRVQCFPGCL------TIQIRTALCVFIVVLIYSVAQGCVVGCL------------------- 694

  Fly  1133 MVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLN 1197
               |::..|.:                |.::...|:||.                |:.|.||
Mouse   695 ---PWAWSSQS----------------NSSLVVLAAGGR----------------RTVLPAL--- 721

  Fly  1198 LTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVS---LA 1259
               |...:|         |::                                 :.|||.   ||
Mouse   722 ---PCESAH---------HAL---------------------------------LCCLVGTLPLA 741

  Fly  1260 TALKLYYLVKALMALAMVAFYTTLIMM----KFG----SGDSFSLVELSRLGMPLGVQMLILLIS 1316
            ..|::..|.|.::...:...|..::.:    |.|    ||.|:..:            |.|||
Mouse   742 IFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPI------------MAILL-- 792

  Fly  1317 FLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL-SDEHTDE 1380
            |...:..|||.|:|..|||::|..|||.|..:|:..:..|..::.|:||.|||.::| |:....:
Mouse   793 FSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMD 857

  Fly  1381 LYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVEKIKTVG 1443
            ||.:.::..||||||||||.|||.| |.:| |..|:|:|||||.|||||:::..:..:|||||:|
Mouse   858 LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIG 922

  Fly  1444 ATYMAAAGLNHEHLRLRGETSEDSV----CDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPL 1504
            :|||||.||    ....|..::.|:    |.|.:||..|...|:|||..::|:|.|||||..||:
Mouse   923 STYMAAVGL----APTAGTRAKKSISSHLCTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPV 983

  Fly  1505 VSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELL--CSRGYTCVKRGEIAVKGKG 1567
            |:||||||:|.||||||||||||||||||...|:||.|....||  ||..:.|  ||:::|||||
Mouse   984 VAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRCSYQFVC--RGKVSVKGKG 1046

  Fly  1568 MMTTFYVH--------------------PKGISESQLISPVRMPA-------GIPLAQTPNLQRQ 1605
            .|.|:::.                    |.|....|...|...||       |:|.|.|......
Mouse  1047 EMLTYFLEGRTDGNSSHGRTFRLERRMCPYGRGGGQARRPPLCPAAGPPVRPGLPPAPTSQYLSS 1111

  Fly  1606 TS 1607
            |:
Mouse  1112 TA 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	61/296 (21%)
		CYCc	526..729	CDD:214485	108/204 (53%)
		Guanylate_cyc	566..753	CDD:278633	108/188 (57%)
		DUF1053	929..1020	CDD:283888	24/96 (25%)
		CYCc	1353..1554	CDD:214485	107/209 (51%)
		Guanylate_cyc	1381..1576	CDD:278633	108/222 (49%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		5/18 (28%)
		AC_N	<158..291	CDD:292831	41/145 (28%)
		CYCc	257..452	CDD:214485	108/204 (53%)
		Guanylate_cyc	293..475	CDD:278633	108/187 (58%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		7/61 (11%)
		CYCc	825..1036	CDD:214485	108/214 (50%)
		Guanylate_cyc	858..1055	CDD:278633	108/202 (53%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118		9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710