DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and CG42637

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	185/861 - (21%)
Similarity:	311/861 - (36%)	Gaps:	255/861 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 GPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRP- 280
            |.|||.|          |||.|.|   .|::|..|..|........:|...| :.|..|.|..|
  Fly   571 GRLRGAV----------VRIKELK---FPRKRDISREIMKEMRLLRELRHDN-INSFIGASVEPT 621

  Fly   281 -----------------LNNE------MYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHR 322
                             :.||      ::.|....:::||::           .:..|.|.|...
  Fly   622 RILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMI-----------YIHNSQLVYHGN 675

  Fly   323 QRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAIC----F 383
            .:..:.::.:            .|:::.::.                     |:..:..|    .
  Fly   676 LKSSNCVVTS------------RWMLQVTDF---------------------GLHELRQCAENES 707

  Fly   384 LG--------YWRC--FANNYLHWA--------AVCTWVLFNIQGFVGQGVGFADREYLVWYILF 430
            :|        .||.  ...|::|.:        |:..:.:|:.:|..|| :.|..:| :|.|:
  Fly   708 IGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQ-INFEPKE-IVDYV-- 768

  Fly   431 VIFVPYAMLPL----PLKWCVVGGTITASCHLAVITIIKLQHGE-ATINPECVLFQIFANFILYT 490
                  ..|||    |.:..|.......||...|:..|:....| ....||   |.:..|.:.
  Fly   769 ------KKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPE---FSVIRNRLK-- 822

  Fly   491 AINVAGMYTKYLTDRGQRLAFIETHK------AMEHKKESEKELQRTQKLLDSILPNIVNNQIRS 549
              .:.|..||.:.|  |.:..:|.:.      ..|..:...:|..:|:.||..:||..|..::
  Fly   823 --KMRGGKTKNIMD--QMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKL-- 881

  Fly   550 EMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDN 614
            .|.:|.:|.           ..|.|:|.|:||.|||.::::::..|:|..||||:..||||....
  Fly   882 TMGQGVEPV-----------SYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGY 935

  Fly   615 HCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRL--HTHVDLNMRIGIHS 677
            ...:|:.:||.|..||.....|...   ||.......|.::.|:|..|:  ..:..|.:|||:|:
  Fly   936 DVYKVETIGDAYMVVSGLPIKNGDR---HAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHT 997

  Fly   678 GSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKC------LNDAYEVE----- 731
            |.|:.||:|.....:.::.:.|..|:.|||.|...::|||.   ||      |...|..|
  Fly   998 GPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISN---KCKLALDKLGGGYITEKRGLV 1059

  Fly   732 --PGNG--------GCRDNHLK-----MLNVKTYLIKR---TEPLRPKRRFGTRSSAHLAGSVAT 778
              .|.|        |..:|.::     |:::...|..|   :..|.|..|..:..:.|..|:.:
  Fly  1060 NMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGS- 1123

  Fly   779 AAPPCATPTALPKSISASGSGSIGG--------VTATGND-----------GASIDGRSLEYAAT 824
                 ...:.:|:::....:.|:.|        |:....|           |..:.|..||.|
  Fly  1124 -----RRQSTVPRAMDGESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFVGGALLESA-- 1181

  Fly   825 IAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTV 889
                              ..||::|.:        |......|.:.||:||..|.|:|     .|
  Fly  1182 ------------------QASLSTLNH--------SETNETNCDMDGGSGGVSGSGSG-----LV 1215

  Fly   890 SSPTAMMSAPLEVQLRPRN--GACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNS------ 946
            ..|.| :..|| ..:||..  .|..:..|.:..|.....:..||.:  :..:|.:.|..
  Fly  1216 RQPNA-LHKPL-AMVRPHRIISAAQLPQLGDNDDDSADTLLRESRS--LDPMPMQQLRKRHDRVK 1276

  Fly   947 -PEDGLNRADSILVDT 961
             |...|::.:|..:||
  Fly  1277 LPPSKLSKNNSRSLDT 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	51/295 (17%)
		CYCc	526..729	CDD:214485	64/210 (30%)
		Guanylate_cyc	566..753	CDD:278633	62/214 (29%)
		DUF1053	929..1020	CDD:283888	9/40 (23%)
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	59/330 (18%)
		HNOBA	<835..881	CDD:285003	10/45 (22%)
		CYCc	860..1052	CDD:214485	64/210 (30%)
		Guanylate_cyc	887..1074	CDD:278633	59/203 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810