DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Ac3

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster

Alignment Length:	1388	Identity:	396/1388 - (28%)
Similarity:	605/1388 - (43%)	Gaps:	349/1388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 EHDLESG-NSLASI-PGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNS----FKQSSLERSYLTY 319
            |.:||:| .::||. ...|||...:....  ...:|..|:   .:|..    ..|..|...|..|
  Fly     2 EANLENGQKTIASTSKSHSQRQTTSRRRQ--NDSDVAGGV---GITGGGVVILPQHVLNELYHNY 61

  Fly   320 THRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSV--------CC-- 374
            :.:||:..|     ..||....|..:|.:                  .|.|..        ||
  Fly    62 SIKQRRSGL-----KWFVFAAALFNIWTI------------------GIPWDQSAPTRVINCCML 103

  Fly   375 --GIANMAICFLG------YWRCFANNYLHWAAVCTWVL----FNIQGFVGQGVGFADREYLVWY 427
              .:|..|:..:|      ..|.|....|.......|:|    |.:  :|.....|:.|:.|.|.
  Fly   104 LAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTV--YVILQPSFSPRDLLGWA 166

  Fly   428 IL--FVIFVPYAMLPLPLKWCVVGGTITASCHLAVITI-IKLQHGEATINPECVLFQIFANFILY 489
            ||  |:::|     .|||:...:|.:|....:...::: :...|.::.::.     |:.||.:|.
  Fly   167 ILLNFLVYV-----TLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSN-----QLAANAVLI 221

  Fly   490 TAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKG 554
            ....:.|:...::.:..|:.||:|..|::|.|...|::....::||.|:||..|..::|.::...
  Fly   222 ATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSS 286

  Fly   555 TDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRV 619
            :...    |.|:|:...:|||||:|||.|||.::|..|||.|||:||:|||||||:||....||:
  Fly   287 SSEA----FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRI 347

  Fly   620 KLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGV 684
            |:|||||||:|....:    ||||||..|..||.|:||||.|:...:..::||:|||:|:|:.|:
  Fly   348 KILGDCYYCISGAPDE----RPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGI 408

  Fly   685 LGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKT 749
            ||.::|.|||:|.||.:||.|||.|..||||||:.||..||..:|||...|..|:..|::..:||
  Fly   409 LGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKT 473

  Fly   750 YLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASI 814
            |.|.:.                    |...|.|||      |.|:
  Fly   474 YFITKV--------------------VKAFASPCA------KKIN-------------------- 492

  Fly   815 DGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGG 879
                 |..|.||.|
  Fly   493 -----ETQAEIAHP--------------------------------------------------- 501

  Fly   880 GTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTD-WIPEIPFKN 943
              .|.|.:|.                                    |:.||...| .:.:.....
  Fly   502 --NPNGSTTD------------------------------------IVSDEDDNDATLDDEELLA 528

  Fly   944 LNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEI----RREYLNPWT--- 1001
            .||..:|              |::.:||..:|.::...:|.:.....|:    ..|.|...|
  Fly   529 QNSVSNG--------------HQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIF 579

  Fly  1002 LKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVL 1066
            |:||:...||.:...||......:|...::....||...:::||.|...|.::...|.:....|:
  Fly   580 LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVI 644

  Fly  1067 VMAEEFPG-LPRCL-----KTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTAD 1125
            .:||.|.| ||:..     :.|....|.:                 |:||.:.|.     ||.::
  Fly   645 SLAESFSGMLPKFFVDVSKRFNDITFVRE-----------------LAAIIIALT-----IGFSN 687

  Fly  1126 EHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRST 1190
            ....|..:....:...::|.||            |:|.|                      :.|.
  Fly   688 VIDMFFFVTFVRTEHIVSESEF------------NVTAS----------------------LESD 718

  Fly  1191 LNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCL 1255
            :|                  |...|...:...|..|....|:.:...| :..:|.||....||.|
  Fly   719 IN------------------LVVEGMVTAEHLLPASFVEQMRDAVPTE-RVLYPSYLSNFGVLIL 764

  Fly  1256 VSLATALKLYYLVKALMALAMVAF--YTTLIMMKFGSGDSFSLVE-------LSRLGMPLGVQML 1311
            :::|...:|.:|.|.|:.|::.|.  |..:.:|:    |.::|.:       :|......|
  Fly   765 IAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQ----DLYALEDDFEHQPIISTRYAASG---- 821

  Fly  1312 ILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSD- 1375
            :||::.|.:... ||.::...|:.|.||.:...:.......|..|:.|:.|:||.|||.:::.:
  Fly   822 LLLVAALALSTL-ARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNT 885

  Fly  1376 --EHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDN--GKACIRILNEIICDFDELLEEPRFASV 1436
              .| |:|||:.:...||:|||:|||.|||||:..|  |..|:|.|||:|.|||.|||.|:|..:
  Fly   886 KRSH-DDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDI 949

  Fly  1437 EKIKTVGATYMAAAGLNHEH-LRLRGETSE--DSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVG 1498
            .||||:|:|||||:|:|.:. :|.....:|  ..:..|||||..:|..|:.||..:||:|.|::|
  Fly   950 IKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMG 1014

  Fly  1499 ICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAV 1563
            |..||:.:||||||||.||||||||||||||:|||:...:||.|.|..:|...|||.::||.:||
  Fly  1015 INHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAV 1079

  Fly  1564 KGKGMMTTFYVHPKGISESQLIS 1586
            ||||.:.|||:..|..|.::.::
  Fly  1080 KGKGQLMTFYLQGKSQSSAEPVA 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	62/291 (21%)
		CYCc	526..729	CDD:214485	98/202 (49%)
		Guanylate_cyc	566..753	CDD:278633	98/186 (53%)
		DUF1053	929..1020	CDD:283888	22/98 (22%)
		CYCc	1353..1554	CDD:214485	105/208 (50%)
		Guanylate_cyc	1381..1576	CDD:278633	107/199 (54%)
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	40/169 (24%)
		CYCc	256..453	CDD:214485	99/204 (49%)
		Guanylate_cyc	294..476	CDD:278633	98/185 (53%)
		CYCc	860..1071	CDD:214485	106/211 (50%)
		Guanylate_cyc	892..1092	CDD:278633	107/199 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.820