Protein Alignment Ac78C and Ac13E

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Alignment Length: 1810
• Identity: 414/1810 - (22%)
• Similarity: 662/1810 - (36%)
• Gaps: 593/1810 - (32%)

  Fly   303 LTNSFKQSSLERSY--LTYTH-RQRQKSLIIVNVVDFVLKIVL--AFVWIMRRSELG-------P 355
            |...|....||..|  ..:.| |.|.:         |.|..:|  :.:|.:.....|       |
  Fly    70 LDPKFDSPVLEEQYQASVFPHVRMRYR---------FTLSYILLCSLMWCLYFVVDGGSEDFWRP 125

  Fly   356 IESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVL--FNIQGFVGQGVGF 418
            |.|  ..||.:.:|        .||:||. :|..:..:....:||...:|  .::......|..|
  Fly   126 ISS--SFSMLSLVT--------IMALCFT-HWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAF 179

  Fly   419 ADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKL---------QHG----- 469
            :...:.. ..|.::.:.|..||:|| |......|:.|....:::.:.:         .||
  Fly   180 SPLGHFA-ICLEIVLLIYTALPMPL-WLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAA 242

  Fly   470 -----EATINP--ECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKE 527
                 ||..:|  ..::.:|.|    :.::::.|::...:.....|..|::..:.:..:::.|.|
  Fly   243 GGSGMEANGDPSNRILILRIMA----HLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEME 303

  Fly   528 LQRTQKLLDSILPNIVNNQIRSE-----------------MYKGTDPTVETQFNKLYVYPMDNVS 575
            .|..:|::.|::|..|.:.:.:|                 |.......|::.|...:::.|:|||
  Fly   304 KQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVS 368

  Fly   576 ILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTR 640
            ||||||.|||.::|..:|:|||:||||||.|||.:...:.|.::..|||||||||...    :.|
  Fly   369 ILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP----EPR 429

  Fly   641 PDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHM 705
            .|||:|.||.||.||.|::......|..:.||:|:|:|:|:||::|.::..||||||||.:||.|
  Fly   430 ADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKM 494

  Fly   706 ESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSA 770
            ||.|.|.:||||:.|...|.|||.:|.|.        ::...:||.:.      .:||..||::
  Fly   495 ESSGKPEQVHISQETSSFLGDAYYLEEGE--------EVFGHRTYFVV------GRRRDFTRTN- 544

  Fly   771 HLAGSVATAAPPCATPTA--LPKSISASGSGSIGGVTA----------TGNDGASID-------- 815
                |::.:.|..||.::  ||.:..||.|.|...|:|          .|...:|::
  Fly   545 ----SLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMR 605

  Fly   816 ---------------------GRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVA-- 857
                                 .|.:.:.|...:|   |..:::::.|..|:..|||..::...
  Fly   606 PRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIP---PVIVVRERPKIIITTKSLPGSLDSDEQP 667

  Fly   858 ----------------------------------------------------MDSRRIR------ 864
                                                                :|..|.|
  Fly   668 PVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEK 732

  Fly   865 -------------------------NGC------------------------------------- 867
                                     |||
  Fly   733 EELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALA 797

  Fly   868 ---------GVMGGAG-------------------------------------------GTGG-G 879
                     ||.||.|                                           .||| .
  Fly   798 SSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVN 862

  Fly   880 GTGPCGMSTVS-SPTAMMSAPLEVQLRPRNGA----------------------CSIQNLAEAID 921
            |.||.|:.... :.|:..:.|:|....||..|                      |.:.....::.
  Fly   863 GAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVG 927

  Fly   922 GKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSI------LVDTK-EDHRVS----------- 968
            |.|:.....|....|........:|.....:|..||      |..|. ..||||
  Fly   928 GGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSIS 992

  Fly   969 -----------VAV--------------LDEEIDEFIEQ-----NIQ----INSNKEIRREY--- 996
                       :||              :.:.:...::|     ::|    :..|...:|.|
  Fly   993 NLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVK 1057

  Fly   997 --LNPWTLKFKDKSQEQKFCQLREDMFR------------------SNMLCVFV-IWIFMVLCQV 1040
              |..::|.||.:..|:.|   |....|                  :..:.:|| |.::
  Fly  1058 PPLRKFSLYFKSRQLERDF---RSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVY------ 1113

  Fly  1041 IIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFIC--GVIVS 1103
                      :|:||...::|                 ..|.|...   |...|||.|  |:.|.
  Fly  1114 ----------LCISVSLFLMT-----------------QNTVSPSF---RLWVTLFSCFTGIQVF 1148

  Fly  1104 MCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPAS 1168
            ...|                      |.|.:....:.|.....|:.....|..:..:...:.| .
  Fly  1149 ALFL----------------------FTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAP-G 1190

  Fly  1169 GGP------TPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSD 1227
            |.|      ..:.:..||........:.|.|:.:.|.                    ::|....|
  Fly  1191 GRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLI--------------------IANFLLLD 1235

  Fly  1228 ASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMA-LAMVAF----YTTLIMMK 1287
            ...:::..      .|..:|:|   :|:|......:|...|:.::| ||.:.|    .:.|::..
  Fly  1236 LEQLEAFE------YHYGFLIF---VCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYS 1291

  Fly  1288 FGSGDSFSLVELSRLGMPL------GVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERE- 1345
            ....|.....|.|.....:      .|::.:.|:..||:|.:..|..|:..||.|.....|.::
  Fly  1292 HNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDK 1356

  Fly  1346 --LTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDEL--YSKMHNLCGVMFASIPNFQDFYSED 1406
              :.||| |:|  |.|:.||:|.|||      ||....  ||:.|:...::||||.||.:.|.|.
  Fly  1357 VRVQNMK-NQA--DMLLHNIIPKHVA------EHLKNTAKYSENHHNIAIIFASIVNFNEMYDES 1412

  Fly  1407 IDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDL 1471
            ...||..:|:|||:|.||||||..|.|.:||||||:|:|:|||:||:..|   || |.::.:..|
  Fly  1413 YLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSH---RG-TGDEHIHTL 1473

  Fly  1472 VEFAFAMKQKLEEINGDAFN-NFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGEN 1535
            :||:.||::.::..|.|... |..||:|:..|.:.:||||..|..|||||:.|||||||||||..
  Fly  1474 MEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLP 1538

  Fly  1536 WRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYV-----HPKGISESQLISPVRMPAGIP 1595
            .|:||.::....|.:| |....||.:.||||..|..|..     :|....|:..:..:.
  Fly  1539 NRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLG------ 1596

  Fly  1596 LAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTA-----------IAGTPTGTPSPQIRRGHRGST 1649
                   .::..|.|....||.|..||..:...           .:.|.|...|.:..:.:.||.
  Fly  1597 -------TKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQANGGSH 1654

  Fly  1650 FS-SVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQ-----ASSSYMP 1698
            .: :...:..:.|:.....|         ....|:.||:|.|.     |:::.||
  Fly  1655 LAPNAAATSHTHTITLTNNN---------NHNSSNINNNIATSNTTTTANNNSMP 1700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	56/299 (19%)
		Guanylate_cyc	566..753	CDD:425528	87/186 (47%)
		Adcy_cons_dom	929..1021	CDD:461877	26/148 (18%)
		Guanylate_cyc	1381..1576	CDD:425528	90/202 (45%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	92/219 (42%)
		PHA03307	836..>1015	CDD:223039	30/178 (17%)
		Guanylate_cyc	1388..1575	CDD:425528	89/191 (47%)