DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and rut

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster

Alignment Length:	1391	Identity:	426/1391 - (30%)
Similarity:	634/1391 - (45%)	Gaps:	328/1391 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 PSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMA 365
            |..|..|:...||..|..||.:.::.|::.|..:.|||..|:|.:               ..:..
  Fly    12 PLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAAL---------------SLTFN 61

  Fly   366 TAITW-----SVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGF-------VGQGVGF 418
            .|.|:     ::.||:..:.:..|   :|......|...:|..:|......       :|.....
  Fly    62 NAATFHNIFNAIVCGLFAVVLVLL---QCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPV 123

  Fly   419 ADREYL---VWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIK-----LQHGEATINP 475
            ..:|.:   ||.|:||:|:.|||:||.:...|..|....|.|:: :|:.|     |::.|..
  Fly   124 DTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHIS-LTVYKIFTDALRYLEYN--- 184

  Fly   476 ECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILP 540
                 |:.||.:::..:||||:....:.:|.||..|::|...:..:.|.:.|.::.::||.|:||
  Fly   185 -----QLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLP 244

  Fly   541 NIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFA 605
            ..|..|:::::..    .|..||:::|:...:|||||||||.|||.|:|:.|||:||::||:||.
  Fly   245 QHVAMQMKNDILS----PVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFG 305

  Fly   606 RFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLN 670
            |||::|.||||||:|:|||||||||...    :.|.|||.|:||.||.||.||..|...|.|.||
  Fly   306 RFDQLAHDNHCLRIKILGDCYYCVSGLP----EPRKDHAKCAVEMGLDMIDAIATVVEATDVILN 366

  Fly   671 MRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNG 735
            ||:|||:|.|:|||||.:||.||||||||.:||||||||.|||||::.|||..|:..||||.|:|
  Fly   367 MRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHG 431

  Fly   736 GCRDNHLKMLNVKTYLI----KRTEPLR-----------PKRRFGTRSSAHLA------------ 773
            ..|.::|:...|.|:.|    .|.:||.           .:|:...|:.:::.
  Fly   432 DERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEP 496

  Fly   774 ---GSVATAAPPCATPTALPKSISASGSGSIG------GVTATGNDGASIDGRSLEYAATIAVPA 829
               .::||.:.|.|. :||...:|..|.|..|      |.|...|.|
  Fly   497 VPFSNIATGSFPSAA-SALGGGVSVGGGGGGGGGGVARGSTCEANSG------------------ 542

  Fly   830 QQPTQLLQQQQKKNISLNSL------PN-------VVEGVAMDSRRIRNGCGVMGGAGGTGGGGT 881
              ..|:.::..:|.|.|..:      |:       |..|..:||       |:.||.|...||..
  Fly   543 --NVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDS-------GISGGGGCVSGGIA 598

  Fly   882 GPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNS 946
            |..|:.            :.|...|.:.|                    ||...|.....||
  Fly   599 GGGGVQ------------VTVGTNPNSTA--------------------STISRIHRHNHKN--- 628

  Fly   947 PEDGLNRADSILVDT-----KEDHRVSVAVLDE---EIDEFIEQNIQINSNKEIRREYLNPWTLK 1003
                 |::.|.:.|.     ::.|  |||...:   .::.|:.|.|...|....:.|:::..||:
  Fly   629 -----NKSQSKVADKFKRPFRKRH--SVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLR 686

  Fly  1004 FKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVM 1068
            |:....|:::.:..:..|.:.|.|..::.|.....||..:||           |:||..
  Fly   687 FRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPR-----------TLILLL------ 734

  Fly  1069 AEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVI-VSMCMLSAIGLVLCPSSTYIGTADEHSRFLR 1132
                                      ||:...| ||..::    |:|.....:|......|..||
  Fly   735 --------------------------LFLFAFIWVSAILM----LLLAVRLKWIIWDISESFSLR 769

  Fly  1133 MVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLN 1197
            |......:.:.....::||:...:.|       |.||..      |:|..:|
  Fly   770 MAITIFTVILIYSVGQVNVFTCVSDH-------PCSGNG------TTSFQND------------- 808

  Fly  1198 LTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATAL 1262
                   |||                                :|:.|:|:..:.....:|::..|
  Fly   809 -------SHR--------------------------------KCSLPQYVSLSAAFAFLSVSVFL 834

  Fly  1263 KLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELS------------RLGMPLGVQMLILLI 1315
            :|..:.|:|:.|.|...|...|             |||            ...:||.:..|..:.
  Fly   835 RLPIIFKSLLVLGMGTIYGLFI-------------ELSHQNIFECYDNRVNASIPLHLISLARIA 886

  Fly  1316 SFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTD- 1379
            .|::.:..|.||||.|:||||:|:.||.:|...|...:..|..::.|:||.|||.::|..:..:
  Fly   887 IFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNN 951

  Fly  1380 -ELYSKMHNLCGVMFASIPNFQDFYSE--DIDNGKACIRILNEIICDFDELLEEPRFASVEKIKT 1441
             |||.:.:...||:|||:|||.:||:|  ..|.|..|:|:|||||.||||||:|.||..::||||
  Fly   952 MELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKT 1016

  Fly  1442 VGATYMAAAGLNHEHLRLRGETS--EDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPL 1504
            ||:||||..||..|:.....:.:  ...:..|:|:..||:..|:|||..::|||.|||||..||:
  Fly  1017 VGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPV 1081

  Fly  1505 VSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMM 1569
            |:||||||||.||||||||||||||||||.....||.:...:.|....:....||.|.|||||.|
  Fly  1082 VAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDM 1146

  Fly  1570 TTFYVHPKGISESQLISPVRMPAGIP 1595
            .|:::...|  ...|...||....:|
  Fly  1147 VTYFLCDSG--NKSLNGEVRNAMSLP 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	66/269 (25%)
		CYCc	526..729	CDD:214485	112/202 (55%)
		Guanylate_cyc	566..753	CDD:278633	112/190 (59%)
		DUF1053	929..1020	CDD:283888	21/98 (21%)
		CYCc	1353..1554	CDD:214485	101/206 (49%)
		Guanylate_cyc	1381..1576	CDD:278633	102/198 (52%)
rut	NP_511156.2	AC_N	<17..255	CDD:292831	64/264 (24%)
		CYCc	230..425	CDD:214485	112/202 (55%)
		Guanylate_cyc	266..438	CDD:278633	108/175 (62%)
		DUF1053	624..696	CDD:283888	18/81 (22%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/232 (17%)
		CYCc	924..1134	CDD:214485	101/209 (48%)
		Guanylate_cyc	954..1151	CDD:278633	102/196 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.820