DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy1

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001100709.1	Gene:	Adcy1 / 305509	RGDID:	1309318	Length:	967	Species:	Rattus norvegicus

Alignment Length:	1236	Identity:	378/1236 - (30%)
Similarity:	559/1236 - (45%)	Gaps:	343/1236 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 VGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITII---KLQHGEATINPEC 477
            :|.|..|..||.:|.|.||.||:||:.....:..|.:.|:.||.|...:   |......|:.
  Rat     1 MGSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLG--- 62

  Fly   478 VLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNI 542
                  ||.:|:..:|:.|::.:.||:|.||.||::....:|.:...|.|.::.::||.|:||..
  Rat    63 ------ANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRN 121

  Fly   543 VNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARF 607
            |..:::.:..|    ..|..|:|:|:...||||||||||.|||.|||:.:||:|||:||:||.:|
  Rat   122 VAMEMKEDFLK----PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKF 182

  Fly   608 DRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRP--DHAVCSVETGLHMIKAIKDVRLHTHVDLN 670
            |.:|.:|||.|:|:|||||||||..      |:|  |||.|.||.||.||..|..|...|.||||
  Rat   183 DELATENHCRRIKILGDCYYCVSGL------TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLN 241

  Fly   671 MRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNG 735
            ||:|:|:|.|:|||||.:||.:|||||||.:||.||:.|:||:|||::.||.|||..||||||:|
  Rat   242 MRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHG 306

  Fly   736 GCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGS 800
            ..|:..|:..|::|:.|
  Rat   307 HERNTFLRTHNIETFFI------------------------------------------------ 323

  Fly   801 IGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRN 865
                                      ||:          .::.|    .|.::......::|::
  Rat   324 --------------------------VPS----------HRRKI----FPGLILSDIKPAKRMK- 347

  Fly   866 GCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDE 930
                                ..||        ..|.|||      ...:.:.:|
  Rat   348 --------------------FKTV--------CYLLVQL------MHCRKMFKA----------- 367

  Fly   931 STTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVA------VLDEEIDEFIEQNIQINSN 989
                   ||||.|:.:.||...|........|..:|.|.:      .....::.:|.:.::....
  Rat   368 -------EIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQT 425

  Fly   990 KEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLS 1054
             |:....||.:|||:|...:|||:.||:::.|.|.::...::.....|..:::||:...:::.|.
  Rat   426 -ELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLV 489

  Fly  1055 VGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSM---CMLSAIGLVLCP 1116
            .....|..|.:.:........|.||      .:..|....:||..:|.|:   |::|.:
  Rat   490 FSICFLVACTLYLHITRVQCFPGCL------TIQIRTALCVFIVVLIYSVAQGCVVSCL------ 542

  Fly  1117 SSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSG 1181
                               |::..|                |.|.::...|:||.
  Rat   543 -------------------PWAWSS----------------HSNSSLVVLAAGGR---------- 562

  Fly  1182 PSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEY 1246
                  |:.|.||      |...:|         |.:
  Rat   563 ------RTVLPAL------PCESAH---------HGL---------------------------- 578

  Fly  1247 LVFTWVLCLVS---LATALKLYYLVKALMALAMVAFYTTLIMM----KFG----SGDSFSLVELS 1300
                 :.|||.   ||..|::..|.|.::...:...|..::.:    |.|    ||.|:..:
  Rat   579 -----LCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPI--- 635

  Fly  1301 RLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILP 1365
                     |.|||  |...:..|||.|:|..|||::|..|||.|..:|:..:..|..::.|:||
  Rat   636 ---------MAILL--FSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLP 689

  Fly  1366 DHVATYYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDEL 1427
            .|||.::| |:....:||.:.::..||||||||||.|||.| |.:| |..|:|:|||||.|||||
  Rat   690 AHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDEL 754

  Fly  1428 LEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCD----LVEFAFAMKQKLEEINGD 1488
            :::..:..:|||||:|:|||||.||    ....|..::.|:..    |.:||..|...|:|||..
  Rat   755 MDKDFYKDLEKIKTIGSTYMAAVGL----APTAGTRAKKSISSHLSTLADFAIDMFDVLDEINYQ 815

  Fly  1489 AFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELL--CSR 1551
            ::|:|.|||||..||:|:||||||:|.||||||||||||||||||...|:||.|....||  ||.
  Rat   816 SYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRCSY 880

  Fly  1552 GYTCVKRGEIAVKGKGMMTTFYV---------HPKGISESQLISP--------VRMPAGIPLAQT 1599
            .:.|  ||:::|||||.|.|:::         |.:.:...:.:.|        .|.|...|.|..
  Rat   881 QFVC--RGKVSVKGKGEMLTYFLEGRTDGSSSHSRSLRLERRMFPYGRGGGGQARRPPLCPAAGP 943

  Fly  1600 P 1600
            |
  Rat   944 P 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	41/137 (30%)
		CYCc	526..729	CDD:214485	108/204 (53%)
		Guanylate_cyc	566..753	CDD:278633	108/188 (57%)
		DUF1053	929..1020	CDD:283888	24/96 (25%)
		CYCc	1353..1554	CDD:214485	106/209 (51%)
		Guanylate_cyc	1381..1576	CDD:278633	107/211 (51%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:292831	41/145 (28%)
		CYCc	105..300	CDD:214485	108/204 (53%)
		Guanylate_cyc	141..323	CDD:278633	108/187 (58%)
		CYCc	673..884	CDD:214485	107/214 (50%)
		Guanylate_cyc	706..903	CDD:278633	107/202 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810