Protein Alignment Ac78C and Adcy9

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_008765747.1
• Gene: Adcy9 / 302950
• RGDID: 1304747
• Length: 1373
• Species: Rattus norvegicus
• Alignment Length: 1506
• Identity: 399/1506 - (26%)
• Similarity: 628/1506 - (41%)
• Gaps: 416/1506 - (27%)

  Fly   249 TESCSIFGNS-NFEHDLESGNSL---ASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQ 309
            :.|||..|:| .....:..|..|   ..:|...:|..:......|.|.|:             ::
  Rat    51 SSSCSSSGDSGGLPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNL-------------EE 102

  Fly   310 SSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCC 374
            :.|||.: ..|.|:.:.:|..|.....:..|..|   :..||::              |...|
  Rat   103 ACLERCF-PQTQRRFRYALFYVGFACLLWSIYFA---VHMRSKV--------------IVMVV-- 147

  Fly   375 GIANMAICFL----GYW-----RCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVW---- 426
                .|:|||    |::     :.:|.:|...:...|.::|.:.         ...::.||
  Rat   148 ----PALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALT---------LAAQFQVWTPLS 199

  Fly   427 --------------------------YILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIK 465
                                      ..:.|:|:.|.::.|||...:..|        .|.:::.
  Rat   200 GRVDSPNHTLTAKAADTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLFLG--------VVYSVLF 256

  Fly   466 LQHGEATINPEC--------VLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKK 522
            ...|....|.:|        :.:::.:..:|:..|:..|::...::....|..|::..:::.|.|
  Rat   257 ETFGYHFRNEDCFPSPDPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGK 321

  Fly   523 ESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQ--------------------FNKLY 567
            :.|.|....::::.|::|.|:.:.:..:..:.::.:|:..                    |....
  Rat   322 DLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKASIQKAPIAFRPFK 386

  Fly   568 VYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQF 632
            :..::.||||||||.|||::::..||..||.:|||||.||||:.|:..|.::..||||||||:..
  Rat   387 MQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGC 451

  Fly   633 ESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSN 697
            .    :.|.|||.|.:|.||.|||||:.........:|||:|:|:|:|:||:||.:::.||||||
  Rat   452 P----EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSN 512

  Fly   698 DVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCR------DNHLKMLNVKTYLIKRTE 756
            ||.:||.||..|:.|:|||||||.|.|:|.||:|.|....|      .:.||  .:|||||...
  Rat   513 DVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVMERLGQSVVADQLK--GLKTYLISGQ- 574

  Fly   757 PLRPKRRFGTRSSAHLAG-----SVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDG 816
              |.|....:.:.|.|:|     ....::.|....||.|.|:|.
  Rat   575 --RAKESHCSCAEALLSGFEVIDDSRVSSGPRGQGTASPGSVSD--------------------- 616

  Fly   817 RSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGV----MGGAGGTG 877
                               |.|..|...:|.:.|:               ||:    ...||..|
  Rat   617 -------------------LAQTVKTFDNLKTCPS---------------CGITFAPKSEAGAEG 647

  Fly   878 GGGTGPC------GMSTVSSPTAMMSAPLEV---------QLRPRNGACS------IQN----LA 917
            |.....|      .....||....:|.||..         ..:.:||..|      :.|    |.
  Rat   648 GAVQNGCQDEPKASTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLC 712

  Fly   918 EAIDGKGL---IIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDT-KEDHRVSVAVLDEEIDE 978
            |.:..||.   :..|:|..  :| :.|||:.      .:.|:..||. |||..:.        |.
  Rat   713 EILQEKGRWAGVSLDQSAL--LP-LRFKNIR------EKTDAHFVDVIKEDSLMK--------DY 760

  Fly   979 FIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKF-CQLREDMFRSNMLCVFVIWIFMVLCQVII 1042
            |.:..|             :.::|.|.|:..||.: ...:|::.:::.:..|....|..|..|.:
  Rat   761 FFKPPI-------------SQFSLNFLDQELEQSYRASYQEEVIKNSPVKTFASATFSSLLDVFL 812

  Fly  1043 IPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCML 1107
               .|.:.:.||:      .|.:...|...|..|..|....|.|:       |.:..:|||:.|:
  Rat   813 ---STTVFLILSI------TCFLKYGATATPPPPAALAVFGADLL-------LEVLSLIVSIRMV 861

  Fly  1108 SAIGLVLCPSSTYI----GTADEHSRFLRMVS-----PYSNISMTEKEFKLNVYLSATIHHNITI 1163
            ..:..||..:...:    |....|.....:||     .||:|:   .||:.|:        |.|:
  Rat   862 FFLEDVLTCTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHIT---SEFETNI--------NFTM 915

  Fly  1164 STPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDA 1228
            .|    |...||.:.                                     |..:...||
  Rat   916 LT----GSAVLVAVV-------------------------------------HYCNFCQLS---- 935

  Fly  1229 SVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDS 1293
            |.|:||                 :..||.....|.||      ::|..   .::::|....:..:
  Rat   936 SWMRSS-----------------LATLVGAGPLLLLY------ISLCQ---DSSIVMSPLDTAQN 974

  Fly  1294 FSLVELS-----------RLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELT 1347
            ||..|.|           |....:|.::::.....|::|.:..|..||:.||.:....:|:...|
  Rat   975 FSASERSPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRT 1039

  Fly  1348 NMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKA 1412
            .::|.|...|.|::||:|.|||    ......:.|||.|:..||:||||.||.:||.|:.:.||.
  Rat  1040 KIQSMRDQADWLLRNIIPYHVA----EQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE 1100

  Fly  1413 CIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLN----------HEHLRLRGETSEDS 1467
            |.|:|||:|.||||||.:|.:.|:|||||:|||||||:|||          .||||:
  Rat  1101 CYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRI-------- 1157

  Fly  1468 VCDLVEFAFAMKQKLEEINGD-AFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDS 1531
               |.|||..|.:.:::.|.: .:.||:||||...|||.:||||..|.:|||||:|||:|||||:
  Rat  1158 ---LFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDT 1219

  Fly  1532 TGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPK-----GISESQL-ISP-VR 1589
            ||...|:||.|.:..:|...||....||.:.|||||.|.| |::||     .:.:.|| ||| :|
  Rat  1220 TGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT-YLYPKCTDNGVVPQHQLSISPDIR 1283

  Fly  1590 MPAGIPLAQTP 1600
            :.....:.::|
  Rat  1284 VQVDGSIGRSP 1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	59/352 (17%)
		Guanylate_cyc	566..753	CDD:425528	93/192 (48%)
		Adcy_cons_dom	929..1021	CDD:461877	21/93 (23%)
		Guanylate_cyc	1381..1576	CDD:425528	102/205 (50%)
Adcy9	XP_008765747.1	AcyC	167..576	CDD:441717	125/434 (29%)
		Guanylate_cyc	385..573	CDD:425528	94/193 (49%)
		Guanylate_cyc	1070..1261	CDD:425528	101/202 (50%)