DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	396	Identity:	96/396 - (24%)
Similarity:	157/396 - (39%)	Gaps:	120/396 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1338 WKEQAERE---------------LTNMKSNRALNDTLIK----------NILPDHVATYYLSDEH 1377
            |:|..|:.               |.:.:.|.:..||||:          :::.:....|....:.
Human   728 WEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDR 792

  Fly  1378 TD-----------------------ELYSKMHNLCGVMFASIPNFQDF--YSEDIDNGKACIRIL 1417
            .|                       |||.::    .:.|:.|..|...  ||..::    .:.:|
Human   793 ADRLNFMLLPRLVVKSLKEKGFVEPELYEEV----TIYFSDIVGFTTICKYSTPME----VVDML 849

  Fly  1418 NEIICDFDELLEEPRFASVEKIKTVGATYMAAAGL----NHEHLRLRGETSEDSVCDLVEFA--- 1475
            |:|...||.:::.   ..|.|::|:|..||.|:||    .:.|           ..|:.:.|
Human   850 NDIYKSFDHIVDH---HDVYKVETIGDAYMVASGLPKRNGNRH-----------AIDIAKMALEI 900

  Fly  1476 --FAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRV 1538
              |....:||.:.|   ....:|:|:.|||..:||:|.:.|.|.::|:|||.||||:|||...|:
Human   901 LSFMGTFELEHLPG---LPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRI 962

  Fly  1539 QVPENTAELL----CSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQT 1599
            .|..:|..:|    |...|..  |||..:||:|..||:::  .|:.:.:...|.          .
Human   963 HVSGSTIAILKRTECQFLYEV--RGETYLKGRGNETTYWL--TGMKDQKFNLPT----------P 1013

  Fly  1600 PNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNP 1664
            |.::.|......||.::...||  ||..|      |..|.:.||          ..|.|..|:..
Human  1014 PTVENQQRLQAEFSDMIANSLQ--KRQAA------GIRSQKPRR----------VASYKKGTLEY 1060

  Fly  1665 VRRNTT 1670
            ::.|||
Human  1061 LQLNTT 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	61/248 (25%)
		Guanylate_cyc	1381..1576	CDD:278633	63/209 (30%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364
		PK_GC-C	480..750	CDD:270946	3/21 (14%)
		Pkinase_Tyr	502..745	CDD:285015	3/16 (19%)
		CYCc	788..979	CDD:214485	56/215 (26%)
		Guanylate_cyc	815..1002	CDD:278633	64/215 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810