DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac78C and GUCY1A1

DIOPT Version :10

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:XP_047306103.1 Gene:GUCY1A1 / 2982 HGNCID:4685 Length:767 Species:Homo sapiens


Alignment Length:224 Identity:71/224 - (31%)
Similarity:117/224 - (52%) Gaps:33/224 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   513 ETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSIL 577
            :.|:|:|.:|      ::|..||.||.|    .::..::::|  ..|:.:       ...||::|
Human   515 QAHQALEEEK------KKTVDLLCSIFP----CEVAQQLWQG--QVVQAK-------KFSNVTML 560

  Fly   578 FADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVS---QFESDNWKT 639
            |:||.|||.:.|:.|..|::.:||.|:.|||:...:....:|:.:||. |||:   ..|||.   
Human   561 FSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YCVAGGLHKESDT--- 621

  Fly   640 RPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANH 704
               |||......|.|::...:|.......:.||||:|||||..||:|.|...:.::.|:|.:||.
Human   622 ---HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANK 683

  Fly   705 MESGGIPGRVHISEATLKCLNDAYEVEPG 733
            .||..:|.::::|..|.:.|.|.    ||
Human   684 FESCSVPRKINVSPTTYRLLKDC----PG 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <216..551 CDD:318454 10/37 (27%)
Guanylate_cyc 566..753 CDD:425528 59/171 (35%)
Adcy_cons_dom 929..1021 CDD:461877
Guanylate_cyc 1381..1576 CDD:425528
GUCY1A1XP_047306103.1 HNOBA 354..543 CDD:462234 10/37 (27%)
Guanylate_cyc 549..720 CDD:425528 60/178 (34%)
Blue background indicates that the domain is not in the aligned region.

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