DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac78C and Adcy8

DIOPT Version :10

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1524 Identity:491/1524 - (32%)
Similarity:725/1524 - (47%) Gaps:413/1524 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 GDGAQMEDNGSGDLP----PSLRASTTSIL------SNLRKKQQGG----PLRGGVAKQTPLRVQ 232
            |.|::...|.:|..|    |.|  |:.|:|      |..|....||    |.|.|..        
  Rat    59 GGGSRKASNPAGSGPNHHAPQL--SSDSVLPLYSLGSGERAHNTGGTKVFPERSGSG-------- 113

  Fly   233 SVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFKSGNVVKG 297
                 .|..:.|.          |:..|.|       |...|..|...||        .|...:|
  Rat   114 -----SASGSGGG----------GDLGFLH-------LDCAPSNSDFFLN--------GGYSYRG 148

  Fly   298 ILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWI-MRRSELGPIESDDG 361
            ::.|:|.||||...|||.|..|...||:||.:::||:|.:.|:.|..:.: :..:.:.|::    
  Rat   149 VIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLK---- 209

  Fly   362 TSMATAITWSVCCGIANMAICFLGYWR--CFANNYLHWAAVCTWVLFNIQ--------GFVGQGV 416
                 .|......|| .:.||.|...|  ..::.||.::.|.|||....|        |.:|.|:
  Rat   210 -----GILLGFFTGI-EVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGI 268

  Fly   417 GFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLF- 480
            |         |:||.:|..|:||||||.|.::.|..|:...:.:..:|          |...:| 
  Rat   269 G---------YVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLI----------PRLAVFS 314

  Fly   481 --QIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIV 543
              |:.|..:|:..:|.||::..||:||.||.||:||.:.:|.:...|.|.||.::|:.|:||..|
  Rat   315 INQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFV 379

  Fly   544 NNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFD 608
            ..::.::|....|..::.||:::|::..:||||||||:||||.|::..|||:||::||:||||||
  Rat   380 VLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFD 444

  Fly   609 RIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRI 673
            |:|.::||||:|:|||||||||...    :.|.|||.|.||.||.|||.|:.||..|..|::|||
  Rat   445 RLAHEHHCLRIKILGDCYYCVSGLP----EPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRI 505

  Fly   674 GIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCR 738
            |||||||:|||||.:||.|||||.||.|||.:||||||||:|||:|||.||:..|.||.|:|..|
  Rat   506 GIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHGKER 570

  Fly   739 DNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGG 803
            :..|:..|::|||||:.|.                                              
  Rat   571 NEFLRKHNIETYLIKQPEE---------------------------------------------- 589

  Fly   804 VTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPN--VVEGVAMDSRRIRNG 866
                                                     ||.|||.  |.|.|:...||    
  Rat   590 -----------------------------------------SLLSLPEDIVKESVSCSDRR---- 609

  Fly   867 CGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDES 931
               ..||..|.|                                                     
  Rat   610 ---NSGATFTEG----------------------------------------------------- 618

  Fly   932 TTDWIPEIPFKNLNSPED---GLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIR 993
              .|.||:||.|:...::   .|.|....|:.......:.|....|||::.||..|.:.|..::|
  Rat   619 --SWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLR 681

  Fly   994 REYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVII-IPRCTRLIICLSVGT 1057
            ||::.|::|.|||.|.|.|:.|:|:::|:||::|.|::.:|:...|.:: ..|...:.|..|:..
  Rat   682 REHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILI 746

  Fly  1058 VILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIG 1122
            ::.:...::..||::..||..|            |:|   |      |.:         :.||:.
  Rat   747 MLHSALVLITTAEDYKCLPLIL------------RKT---C------CWI---------NETYLA 781

  Fly  1123 TADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFV 1187
            .                          ||.:.|:|..|                         |:
  Rat   782 R--------------------------NVIIFASILIN-------------------------FL 795

  Fly  1188 RSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWV 1252
            .:.:|.|..:....:|                |.||:::.::|.   :|:   |::|||.|||.|
  Rat   796 GAVINILWCDFDKSIP----------------LKNLTFNSSAVF---TDI---CSYPEYFVFTGV 838

  Fly  1253 LCLVSLATALKLYYLVKALMALAMVAFYTTL-------IMMKFG----SGDSFSLVELSRLGMPL 1306
            |.:|:.|..|:|..::|..:.|.|:|.|..|       :.:.:.    ||:.|           |
  Rat   839 LAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDF-----------L 892

  Fly  1307 GVQ--MLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVA 1369
            |.:  .|:|:..||:.|.||.:.:|.|:||||:|:.||:.|:..||..|..|:.:::||||.|||
  Rat   893 GTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVA 957

  Fly  1370 TYYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEP 1431
            .::| .|...:||||:.::..||||||||.|.||||: :::| |..|:|:|||||.||||||.|.
  Rat   958 RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGED 1022

  Fly  1432 RFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDS---VCDLVEFAFAMKQKLEEINGDAFNNF 1493
            ||..:|||||:|:||||.:||:.|.     :..||.   :|.|.:|:.|:.:.::|||..:||||
  Rat  1023 RFQDIEKIKTIGSTYMAVSGLSPEK-----QQCEDKWGHLCALADFSLALTESIQEINKHSFNNF 1082

  Fly  1494 QLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKR 1558
            :||:||..|.:|:|||||:||.|||||.|||:||||||||.:.|:||||.|..:|..:|:....|
  Rat  1083 ELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYR 1147

  Fly  1559 GEIAVKG----KGMMTTFYVHPKGISESQLISPVRMPAGIPLA-------QTPNLQRQTS--HHG 1610
            |||.|||    :|.:.|:::..:......::.|.|:|....||       |:.|.|||..  :..
  Rat  1148 GEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNEN 1212

  Fly  1611 SFSAVVFGMLQASKRSTAIAGTPTGTPSP 1639
            |.|.::   .....|.|.:  ||:| |.|
  Rat  1213 SNSGII---KSHYNRRTLL--TPSG-PEP 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <216..551 CDD:318454 99/352 (28%)
Guanylate_cyc 566..753 CDD:425528 114/186 (61%)
Adcy_cons_dom 929..1021 CDD:461877 30/94 (32%)
Guanylate_cyc 1381..1576 CDD:425528 106/203 (52%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179 43/159 (27%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106 14/48 (29%)
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117 18/72 (25%)
AcyC 211..564 CDD:441717 170/376 (45%)
Guanylate_cyc 402..586 CDD:425528 115/187 (61%)
Adcy_cons_dom 614..709 CDD:461877 32/149 (21%)
Guanylate_cyc 970..1169 CDD:425528 106/203 (52%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 51/136 (38%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212 5/14 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

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