Protein Alignment Ac78C and Adcy10

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_766617.2
• Gene: Adcy10 / 271639
• MGIID: 2660854
• Length: 1614
• Species: Mus musculus
• Alignment Length: 1139
• Identity: 217/1139 - (19%)
• Similarity: 362/1139 - (31%)
• Gaps: 394/1139 - (34%)

  Fly   530 RTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTS-- 592
            |.|:|.|..:..|..:.....:|....|      .:..|...|.| ::|.||.|||.:..|.|
Mouse     4 RRQELQDRAIVKIAAHLPDLIVYGDFSP------ERPSVKCFDGV-LMFVDISGFTAMTEKFSTA 61

  Fly   593 ------AQQLVKILNDLFARFDRIAEDNHCLRVKLL---GDCYYCVSQFESDN----WKTRPDH- 643
                  |:|||:|||...:   .|.|       |:|   ||    :.:|..|.    ||.....
Mouse    62 MYMDRGAEQLVEILNYYIS---AIVE-------KVLIFGGD----ILKFAGDALLALWKVERKQL 112

  Fly   644 -------AVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHF--------- 692
                   ..||:|  :|.:...|:.  ...:|:.::||:.:|.:...|.|::..::
Mouse   113 KNIITVVIKCSLE--IHGLFEAKEA--EEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVD 173

  Fly   693 DV-------WSNDVIIA---------NHMESGGIPGR--VHIS-----------EATLKCLN--D 726
            ||       ..||||::         :.:|...||.:  |.:|           |...||:.  |
Mouse   174 DVRLAQNMAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFTKCMGFMD 238

  Fly   727 AYEVEPGNGGCRDNHLKM-----------LNVKTY----LIKRTE---------PLRP------K 761
            .|.     .|...|.|::           |:::.|    ::|:.:         .|||      .
Mouse   239 YYP-----SGDHKNFLRLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVN 298

  Fly   762 RRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIA 826
            ..|..:....:.||...||  |...|::.|..    .|.|..|        .:..:...:.....
Mouse   299 LMFKEQDKVEVIGSAIQAA--CVHITSVLKVF----RGQINKV--------FMFDKGCSFLCVFG 349

  Fly   827 VPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNG---CGVMGGAGGTGGGGTGPCGMST 888
            .|.::....:....:..:.:....:.|..:...|..:.:|   ||::|               .|
Mouse   350 FPGEKAPDEITHALESAVDIFDFCSQVHKIRTVSIGVASGIVFCGIVG---------------HT 399

  Fly   889 VSSPTAMMSAPLEVQLR-----PRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPE 948
            |.....::...:.:..|     |...:|.    :...||..|      ...:..|:|.|.:....
Mouse   400 VRHEYTVIGQKVNIAARMMMYYPGIVSCD----SVTYDGSNL------PAYFFKELPKKVMKGVA 454

  Fly   949 D--------GLNR-----ADSILVDTKEDHRVSVAVLDEEIDEF---IEQNIQINSNKEIRREYL 997
            |        |||.     ...::.:..|.:.:...|  .|||.|   ::..:..|.::.:..|.|
Mouse   455 DPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRV--REIDYFMSTMKDFLMTNCSRVLMYEGL 517

  Fly   998 NPWTLKFKDKSQ---EQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVI 1059
            ..:     .|||   |.::...:.:..|:                         :.|.|:..:..
Mouse   518 PGY-----GKSQVLMEIEYLASQHENHRA-------------------------VAIALTKISFH 552

  Fly  1060 LTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSM-----CMLSAIGLVLCPSST 1119
            ..|..:.::.....||..|        .|.::|:|.....|...:     |:|:.|..|..|.|.
Mouse   553 QNFYTIQILMANVLGLDTC--------KHYKERQTNLQNRVKTLLDEKFHCLLNDIFHVQFPVSR 609

  Fly  1120 YIGTADEHSRFLRMVSPYSNISMTEKEFKLNV----YLSATIHHN--ITISTPASGGPTPLVDIT 1178
            .:                |.:|...|:.:|..    .|:.|:...  |.|...|.     .||.|
Mouse   610 EM----------------SRMSKIRKQKQLEALFMKILAQTVREERIIFIIDEAQ-----FVDGT 653

  Fly  1179 SSGPSDEFVRSTLNALTLNLTP--PLP-------QSHRPYTLTTNG-------HSVSLSNLSYSD 1227
            |....::.:||....:.::|.|  .:|       ..:|..|..|.|       ......:||.|.
Mouse   654 SWAFIEKLIRSMPIFIVMSLAPFSEVPCAAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSS 718

  Fly  1228 ASVMQSSSDVEGQCAHPEY-------------LVF-----------TW-------------VLCL 1255
            ......|..|||.|..|.|             |:|           ||             :...
Mouse   719 IPRELDSYLVEGSCGIPYYCEELLKNLDHHRVLLFQQAETEQKTNVTWNNMFKHSVRPTDDMQLF 783

  Fly  1256 VSLATALK-LYYLVKA--LMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISF 1317
            .|::...| :.|||..  |..|:..|           |....|||:|.  .|.|..|||:...:.
Mouse   784 TSISEGQKEVCYLVSGVRLNNLSPPA-----------SLKEISLVQLD--SMSLSHQMLVRCAAI 835

  Fly  1318 LVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELY 1382
            :.:......|.|:..    .|         |||       .:||.:     ||  |.:.:....:
Mouse   836 IGLTFTTELLFEILP----CW---------NMK-------MMIKAL-----AT--LVESNVFNCF 873

  Fly  1383 SKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYM 1447
            ....:|...:..::|.|:..|.                             :...|:|. |.||
Mouse   874 RSSKDLQLALKQNVPTFEVHYR-----------------------------SLALKLKE-GLTY- 907

  Fly  1448 AAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQK 1481
               |...|...:.||..|   |.::.|...:.||
Mouse   908 ---GEEEELREMEGEVVE---CRILRFCRPIMQK 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	5/20 (25%)
		CYCc	526..729	CDD:214485	61/261 (23%)
		Guanylate_cyc	566..753	CDD:278633	60/264 (23%)
		DUF1053	929..1020	CDD:283888	20/109 (18%)
		CYCc	1353..1554	CDD:214485	23/129 (18%)
		Guanylate_cyc	1381..1576	CDD:278633	18/101 (18%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636	47/192 (24%)
		CHD	292..461	CDD:143636	30/207 (14%)
		COG3899	485..>959	CDD:226415	112/589 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900