DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy6

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001257714.1	Gene:	Adcy6 / 25289	RGDID:	2035	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1304	Identity:	386/1304 - (29%)
Similarity:	608/1304 - (46%)	Gaps:	300/1304 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATA 367
            :..|:.:.|||.|..|..:..|.|| :::.|:..::.::|.|            .:.........
  Rat   140 SKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTF------------HAAPALPQPAY 192

  Fly   368 ITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYL----VWYI 428
            :....|..:..:.:..:.....|..:.: |  |.::|:..|...|..|...|.....    :|..
  Rat   193 VALLTCASVLFVVLMVVCNRHSFRQDSM-W--VVSYVVLGILAAVQVGGALAANPRSPSAGLWCP 254

  Fly   429 LFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAIN 493
            :|.:::.|.:||:.::..|:.|...::.||  |....|.:|:..:     ..|:.||.:|:...|
  Rat   255 VFFVYITYTLLPIRMRAAVLSGLGLSTLHL--ILAWHLNNGDPFL-----WKQLGANVVLFLCTN 312

  Fly   494 VAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPT 558
            ..|:.|.|..:..||.||.||...::.:...:.|.::.::||.|:||..|..:::.::....:
  Rat   313 AIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE-- 375

  Fly   559 VETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLG 623
             :..|:|:|:...||||||||||:|||.|||:.:||:||..||:||||||::|.:|||||:|:||
  Rat   376 -DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 439

  Fly   624 DCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNK 688
            |||||||...    :.|.|||.|.||.|:.||:||..||..|.|::|||:|||||.|.|||||.:
  Rat   440 DCYYCVSGLP----EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 500

  Fly   689 KWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIK 753
            ||.||||||||.:|||||:||..||:||:.|||:.||..||||||.||.|:.:||...::|:||.
  Rat   501 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLIL 565

  Fly   754 RTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRS 818
            .....|.:.:                        |:...:..:.:.|:.|:
  Rat   566 GASQKRKEEK------------------------AMLVKLQRTRANSMEGL-------------- 592

  Fly   819 LEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGP 883
                    :|...|.:...:.:                  ||:..|.    ||
  Rat   593 --------MPRWVPDRAFSRTK------------------DSKAFRQ----MG------------ 615

  Fly   884 CGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPE 948
                                                       |:|.|          |.....:
  Rat   616 -------------------------------------------IDDSS----------KENRGAQ 627

  Fly   949 DGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKF 1013
            |.||..|                   |:|||:.:.|...|..::|::::..:.|.|:.:..|:|:
  Rat   628 DALNPED-------------------EVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKY 673

  Fly  1014 CQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPG--LP 1076
            .:..:..|.:.:.|..:::.|:...|.::.|. :.||:.:..|..:|....||:.|....|  .|
  Rat   674 SRKVDPRFGAYVACALLVFCFICFIQFLVFPH-SALILGIYAGIFLLLLVTVLICAVCSCGSFFP 737

  Fly  1077 RCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNIS 1141
            ..|:..|..:|..|...|              |:|:              .|..|..:|..:|:
  Rat   738 NALQRLSRSIVRSRVHST--------------AVGV--------------FSVLLVFISAIANM- 773

  Fly  1142 MTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSH 1206
                         .|..|            |||              .|..|..|||||
  Rat   774 -------------FTCSH------------TPL--------------RTCAARMLNLTP------ 793

  Fly  1207 RPYTLTTNGHSVSLSNLSYS---DASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLV 1268
                  ::..:..|..|:||   :|.:.:.::..   |:.|||.|.:.:|.|::.:..|.:..:.
  Rat   794 ------SDVTACHLRQLNYSLGLEAPLCEGTAPT---CSFPEYFVGSVLLSLLASSVFLHISSIG 849

  Fly  1269 KALMALAMVAFYTTLIMM------------------KFGSGDSFSLVELSRLG-MPLGVQMLILL 1314
            |.:|...:...|..|:::                  ...|.::|..::...:| :.|.....::|
  Rat   850 KLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLASSNETFDGLDCPAVGRVALKYMTPVIL 914

  Fly  1315 ISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-HT 1378
            :.|.:.:..||:.||.|:||||:||.||..|...|:..:|.|..|:.||||..||.::|:.| ..
  Rat   915 LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRN 979

  Fly  1379 DELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVEKIKT 1441
            ||||.:......||||||.||.:||.| :.:| |..|:|:|||||.||||::.|.||..:|||||
  Rat   980 DELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1044

  Fly  1442 VGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVS 1506
            :|:|||||:|||   .....:.....:..|.::|..:.::::.||..:|||||:::|:..||:|:
  Rat  1045 IGSTYMAASGLN---ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVA 1106

  Fly  1507 GVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTT 1571
            ||||||||.||||||||||:|||||||...|:||..:..::|.::||....||.:.|||||.|||
  Rat  1107 GVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTT 1171

  Fly  1572 FYVH 1575
            ::::
  Rat  1172 YFLN 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	54/251 (22%)
		CYCc	526..729	CDD:214485	110/202 (54%)
		Guanylate_cyc	566..753	CDD:278633	114/186 (61%)
		DUF1053	929..1020	CDD:283888	18/90 (20%)
		CYCc	1353..1554	CDD:214485	99/203 (49%)
		Guanylate_cyc	1381..1576	CDD:278633	97/197 (49%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:292831	54/264 (20%)
		CYCc	346..541	CDD:214485	110/201 (55%)
		Guanylate_cyc	382..566	CDD:278633	115/187 (61%)
		DUF1053	594..680	CDD:283888	26/191 (14%)
		CYCc	956..1157	CDD:214485	99/203 (49%)
		Guanylate_cyc	982..1176	CDD:278633	97/197 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810