DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	101/381 - (26%)
Similarity:	165/381 - (43%)	Gaps:	71/381 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 SLVELSRLGMPLG-------VQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTN-MKS 1351
            ||.||....|.|.       .:.||||        ...||.|:........|::..|.|:| :..
  Rat   376 SLQELEESKMHLSDIAPHDTTRDLILL--------NQQRLAEMELSCQLEKKKEELRVLSNHLAI 432

  Fly  1352 NRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKAC--- 1413
            .:...:||:..:||:|||...   :...::.:.....|.::|:.:..|.:..:       ||
  Rat   433 EKKKTETLLYAMLPEHVANQL---KEGRKVAAGEFETCTILFSDVVTFTNICA-------ACEPI 487

  Fly  1414 --IRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAF 1476
              :.:||.:...||.|..   ...|.|::|:|..||...|:        ....|.....:..||.
  Rat   488 QIVNMLNSMYSKFDRLTS---VHDVYKVETIGDAYMVVGGV--------PVPVESHAQRVANFAL 541

  Fly  1477 AM----KQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWR 1537
            .|    |:.:..:.|:.   .|:||||.:||:::||:|.:.|.|.::|:|||.||||:|.|...:
  Rat   542 GMRISAKEVMNPVTGEP---IQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSK 603

  Fly  1538 VQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFY-VHPKGISESQLISPVRMPA--------G 1593
            |.:.......|.::|:..|:||||.|||||.|||:: :.....:|.:::.....||        |
  Rat   604 VHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPG 668

  Fly  1594 IPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTP----------TGTPSP 1639
            ..:.::|.:.|.|.|.   ..|..|....:.....:||:|          ...|||
  Rat   669 NQVRKSPAVPRNTDHQ---QQVYKGDPADASNEVTLAGSPVAGRNSTDAVNNQPSP 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	55/209 (26%)
		Guanylate_cyc	1381..1576	CDD:278633	61/204 (30%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002
		HNOBA	267..453	CDD:285003	24/84 (29%)
		CYCc	432..622	CDD:214485	55/213 (26%)
		Guanylate_cyc	459..642	CDD:278633	61/203 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810