DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Gucy2f

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001007577.1	Gene:	Gucy2f / 245650	MGIID:	105119	Length:	1108	Species:	Mus musculus

Alignment Length:	722	Identity:	169/722 - (23%)
Similarity:	255/722 - (35%)	Gaps:	249/722 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 RGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSI----FGNSNFE-----------------HD 263
            |..|:.|....|||.|        .|:....|.|:    :.|||..                 .|
Mouse   527 RASVSFQIISEVQSGR--------SPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGD 583

  Fly   264 LESGNSLASIPGQSQRPLNNE----------------MYSAFKSGNVVKGILCPSLTNS------ 306
            ::|..|.||...:..:.|.:|                :.|.|.|...::.|    |||.
Mouse   584 IKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDI----LTNDDVKLDW 644

  Fly   307 -FKQSSL-----ERSYLTYTHRQ----RQKSLIIVNVVDFVLKIV-LAF---VWIMRRSELGPIE 357
             ||.|.|     ...||  .||:    |.||...|....||||:. ..|   :.::|.||..|.|
Mouse   645 MFKSSLLLDLIKGMKYL--HHREFIHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEEPSE 707

  Fly   358 SDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADRE 422
            .:                                   |.|.|.   .|....|.:..| .||...
Mouse   708 EE-----------------------------------LLWTAP---ELLRAPGGIRLG-SFAGDV 733

  Fly   423 YLVWYILFVIFV---PYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHG--EATINP-----EC 477
            |....|:..:.|   |:.|:.||.|              .:|..:|:...  ...::|     ||
Mouse   734 YSFAIIMQEVMVRGAPFCMMDLPAK--------------EIIDRLKMPPPVYRPVVSPEYAPAEC 784

  Fly   478 V-------------------LFQIFANF-------ILYTAINVAGMYTKYLTDRGQRLAFIETHK 516
            :                   :|..|..|       |:.:.:.:...|:..|.|           .
Mouse   785 LQLMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLED-----------L 838

  Fly   517 AMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADI 581
            ..|..:|.|.|.|:|:|||..:||..|...::    ||.  |||.:       ..|.|::.|:||
Mouse   839 IRERTEELEIEKQKTEKLLTQMLPLSVAESLK----KGC--TVEPE-------GFDLVTLYFSDI 890

  Fly   582 KGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVC 646
            .|||.:::.:...::|.:||||:..||.|...:...:|:.:||.|...|.....|...   ||..
Mouse   891 VGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSR---HAAE 952

  Fly   647 SVETGLHMIKAIKDVRLH--THVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGG 709
            .....|.::.::...::.  ..|.:.:|||:|||.|:.||:|.....:.::.:.|..|:.|||.|
Mouse   953 IANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTG 1017

  Fly   710 IPGRVHISEAT---LKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAH 771
            :|.|:|:|.:|   |:.|::.||||                   |..||| |:.|   ||..:..
Mouse  1018 LPYRIHVSLSTVTILQTLSEGYEVE-------------------LRGRTE-LKGK---GTEETFW 1059

  Fly   772 LAGSVATAAP-PCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQL 835
            |.|......| |...|                    .|.||..  |..|           ||.::
Mouse  1060 LVGKKGFTKPLPVPPP--------------------VGKDGQV--GHGL-----------QPAEI 1091

  Fly   836 LQQQQKK 842
            ...|::|
Mouse  1092 AAFQRRK 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	68/318 (21%)
		CYCc	526..729	CDD:214485	63/207 (30%)
		Guanylate_cyc	566..753	CDD:278633	54/191 (28%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594
		PKc_like	545..815	CDD:419665	65/328 (20%)
		HNOBA	<824..869	CDD:400168	15/55 (27%)
		CYCc	848..1040	CDD:214485	63/207 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810