Protein Alignment Ac78C and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: XP_011243363.2
• Gene: Gucy1b2 / 239134
• MGIID: 2660873
• Length: 829
• Species: Mus musculus
• Alignment Length: 557
• Identity: 133/557 - (23%)
• Similarity: 221/557 - (39%)
• Gaps: 139/557 - (24%)

  Fly  1113 VLCPSSTYIGTADEHSRFLRMVSPYSNIS------MTEKEFKLNVYLSATIHHNITISTPASGGP 1171
            |.|.:..:....||   .||:.....||.      :|:| |.|:.|.| .:|..:|.
Mouse   381 VFCNAFPFHVVFDE---ALRVKQAGVNIQKYVPGILTQK-FGLDEYFS-IVHPQVTF-------- 432

  Fly  1172 TPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSD 1236
                :|:|   ..:|:.|.....|.....|.....:| ||...|..:.:.:|
Mouse   433 ----NISS---ICKFINSQFILKTRREMMPEAWKSQP-TLKLRGQMIWMESL------------- 476

  Fly  1237 VEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSR 1301
               :|     :||   :|...|.:   |..|.::.|.|:.:|.:.|
Mouse   477 ---KC-----MVF---MCSPKLRS---LQELEESKMHLSDIAPHDT------------------- 508

  Fly  1302 LGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTN-MKSNRALNDTLIKNILP 1365
                  .:.||||        ...||.|:........|::..|.|:| :...:...:||:..:||
Mouse   509 ------TRDLILL--------NQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLP 559

  Fly  1366 DHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKAC-----IRILNEIICDFD 1425
            :|||...   :...::.:.....|.::|:.:..|.:..:       ||     :.:||.:...||
Mouse   560 EHVANQL---KEGKKVAAGEFETCTILFSDVVTFTNICA-------ACEPIQIVNMLNSMYSKFD 614

  Fly  1426 ELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAM----KQKLEEIN 1486
            .|   .....|.|::|:|..||...|:        ....|.....:..||..|    |:.:..:.
Mouse   615 RL---TNIHDVYKVETIGDAYMVVGGV--------PVPVESHAQRVANFALGMRISAKEVMNPVT 668

  Fly  1487 GDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSR 1551
            |:.   .|:||||.:||:::||:|.:.|.|.::|:|||.||||:|.|...:|.:.......|.::
Mouse   669 GEP---IQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENK 730

  Fly  1552 GYTCVKRGEIAVKGKGMMTTFYV-------------HPKGISESQLISPVRMPAGIPLAQTPNL- 1602
            |:..|.||||.|||||.|||:::             .|..:::.:..|..|.....|.|...|:
Mouse   731 GFEIVTRGEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRAVLSNMD 795

  Fly  1603 QRQTSHHGSFSAVVFGMLQASKRSTAIAGT-PTGTPS 1638
            ..|...:.|..|.|.|   .:.|:.::.|. ||..|:
Mouse   796 HHQQQVYNSDPADVLG---TASRTASVKGKHPTPLPT 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	55/209 (26%)
		Guanylate_cyc	1381..1576	CDD:278633	61/216 (28%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167
		HNOBA	380..566	CDD:400168	56/265 (21%)
		Guanylate_cyc	572..754	CDD:306677	61/202 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810