DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	1235	Identity:	233/1235 - (18%)
Similarity:	390/1235 - (31%)	Gaps:	404/1235 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 LRPKRRFGT-----------RSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDG 811
            |..:.|||:           |...:|.|:..|.|  ..|.|....|.|:|.|..:..|..|....
Human    10 LNRRSRFGSRERDWLREDVKRGCVYLYGADTTTA--TTTTTTSSSSSSSSSSSDLHLVLCTVETP 72

  Fly   812 ASI----DGRSLEY------AATIAVPAQQPTQLLQ--------------QQQKKNISLNSLPNV 852
            ||.    :||...|      ......|.::|.|::.              |::..|..|
Human    73 ASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPVRIQEEATNPDL------ 131

  Fly   853 VEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLA 917
                         ||.:.       ..|..||.|..:.  ..::|....|    |.|...:...|
Human   132 -------------GCMIR-------FYGEKPCHMDRLD--RILLSGIYNV----RKGKTQLHKWA 170

  Fly   918 E---AIDGKGLIIEDESTTDW-------IP----------------------------EIPFKNL 944
            |   .:.|..||:  .|..|.       :|                            .:.|:.|
Human   171 ERLVVLCGTCLIV--SSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETL 233

  Fly   945 NSPEDGLNRADSILVDTKEDHRVSVAVLD----EEIDE--FIEQNIQINSNKEIRREYLNPWTLK 1003
            ...:....:|..::     ..|:|...|.    ||:.|  |..|:|          .|||   |:
Human   234 AEYQRWQRQASKVV-----SQRISTVDLSCYSLEEVPEHLFYSQDI----------TYLN---LR 280

  Fly  1004 FKDKSQEQ--------KFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRL-IIC------- 1052
            ......|:        ||.||:......|.|.:|.|    :||::..:   |.| :.|
Human   281 HNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPI----LLCEISTL---TELNLSCNGFHDLP 338

  Fly  1053 ------LSVGTVILTFCCVLVMAEEFPGLPRCLK-----TNSAKLVHQRQRRTLFICGVIVSMCM 1106
                  |::.|:.|....:..:.||...|.:...     .|.:::....::.|:....|:...|
Human   339 SQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNC- 402

  Fly  1107 LSAIGLVLCPSSTYIGTAD---EHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPAS 1168
            |..:.|.:.....:|...|   .|.:.:.:.:...|..:|..:.:.|...      ::.:|:..|
Human   403 LEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLT------DLDLSSLCS 461

  Fly  1169 -----GGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTN-----------GHS 1217
                 .|...|.::|.||.|...:.::.|.||.....|:|.......|:.|           ...
Human   462 LEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKK 526

  Fly  1218 VSLSNLSYS-----DASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMV 1277
            :.:.::||:     ...::.|.|..:....|      ..|..|.:|...:.|..|.....||..:
Human   527 IEVLDVSYNLLTEVPVRILSSLSLRKLMLGH------NHVQNLPTLVEHIPLEVLDLQHNALTRL 585

  Fly  1278 --AFYTTLIMMKFGSGDSFSLVEL-------SRLGMPLGVQMLILLISFLVMVC-------YHAR 1326
              ..::..:.:::.:..:.||..|       ..|.|   :|:|.|..:.|...|       .|.|
Human   586 PDTLFSKALNLRYLNASANSLESLPSACTGEESLSM---LQLLYLTNNLLTDQCIPVLVGHLHLR 647

  Fly  1327 LVEV---------TSRLDFIWKEQAERELTNMKSNRA---------------------------- 1354
            ::.:         .|:|:.:  ||.| || |:..|:.
Human   648 ILHLANNQLQTFPASKLNKL--EQLE-EL-NLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPE 708

  Fly  1355 ----------------LNDTLIKNILP------------------------DHVATYYLSDE--- 1376
                            |.:.||...||                        .|:.|..:..:
Human   709 ILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLP 773

  Fly  1377 HTD-------------ELYSKMHNLCGVMFASIPNFQDFYSE---------DIDNGKACIRILNE 1419
            .||             |:..:.:.||....|     .|.::|         |.|..:...|:|.
Human   774 TTDSTVTSTFWSHGLAEMAGQRNKLCVSALA-----MDSFAEGVGAVYGMFDGDRNEELPRLLQ- 832

  Fly  1420 IICDF-DELLEEPRFASVEKIKTVGATYMAAAGL-NHEHLRLRGETSEDSVCDLVEFAFAMKQKL 1482
              |.. |.||||.:.::.:.:      :||...| :|..|.:.|:....|         |:...:
Human   833 --CTMADVLLEEVQQSTNDTV------FMANTFLVSHRKLGMAGQKLGSS---------ALLCYI 880

  Fly  1483 EEINGDAFNNFQL---RVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQ----- 1539
            .....|..::|.|   .||.|...|..|    .|||     ....|.|......|..||:
Human   881 RPDTADPASSFSLTVANVGTCQAVLCRG----GKPV-----PLSKVFSLEQDPEEAQRVKDQKAI 936

  Fly  1540 VPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLIS-PVRMPAGIPLAQTPNLQ 1603
            :.|:..    ..|.||..|         |:...|::|..:.:..:.| |:.:...:.:.....|.
Human   937 ITEDNK----VNGVTCCTR---------MLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALW 988

  Fly  1604 RQTSHHGSFSAV--VFGMLQASKRSTAIAGT-----PTGTPSPQIRRGHRGSTFSSVRLSQKSTT 1661
            ...|:..:.:||  |...|.|:|:...:|.:     ..|.....:..|..|.|.....|    |.
Human   989 EHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGL----TL 1049

  Fly  1662 VNPVR-RNTTRVRGRSYRQKKSSSNNSIVTQASSSYMPSFRRIDQIETTISKSHN-----DALXP 1720
            ..||. .:||.::........|||:.  :....||.|.:.....::.:|.|..||     .|| |
Human  1050 PGPVGFASTTTIKDAPKPATPSSSSG--IASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLP 1112

Fly 1721 1720
Human 1113 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888	24/139 (17%)
		CYCc	1353..1554	CDD:214485	51/303 (17%)
		Guanylate_cyc	1381..1576	CDD:278633	46/213 (22%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	14/101 (14%)
		LRR 1	250..271		7/20 (35%)
		leucine-rich repeat	253..273	CDD:275380	5/19 (26%)
		LRR 2	273..296		6/35 (17%)
		leucine-rich repeat	274..300	CDD:275380	8/38 (21%)
		LRR 3	300..321		8/24 (33%)
		leucine-rich repeat	301..323	CDD:275380	7/25 (28%)
		LRR_RI	313..606	CDD:238064	52/312 (17%)
		LRR_8	322..380	CDD:290566	9/60 (15%)
		LRR 4	323..344		3/23 (13%)
		leucine-rich repeat	324..346	CDD:275380	3/24 (13%)
		LRR 5	346..368		4/21 (19%)
		leucine-rich repeat	347..369	CDD:275380	5/21 (24%)
		LRR 6	369..390		1/20 (5%)
		leucine-rich repeat	370..416	CDD:275380	6/46 (13%)
		LRR 7	392..412		4/20 (20%)
		LRR 8	416..439		3/22 (14%)
		leucine-rich repeat	418..440	CDD:275380	3/21 (14%)
		LRR 9	440..460		3/25 (12%)
		leucine-rich repeat	442..461	CDD:275380	3/24 (13%)
		LRR 10	461..480		5/18 (28%)
		leucine-rich repeat	462..481	CDD:275380	5/18 (28%)
		LRR 11	481..502		5/20 (25%)
		leucine-rich repeat	482..503	CDD:275380	5/20 (25%)
		LRR 12	503..524		2/20 (10%)
		leucine-rich repeat	504..526	CDD:275380	2/21 (10%)
		LRR 13	526..547		2/20 (10%)
		leucine-rich repeat	527..549	CDD:275380	3/21 (14%)
		LRR_8	549..606	CDD:290566	9/62 (15%)
		LRR 14	549..570		5/26 (19%)
		leucine-rich repeat	550..565	CDD:275380	3/20 (15%)
		LRR 15	571..592		4/20 (20%)
		leucine-rich repeat	572..595	CDD:275380	4/22 (18%)
		LRR 16	595..616		3/20 (15%)
		leucine-rich repeat	596..645	CDD:275380	10/51 (20%)
		LRR 17	621..644		6/25 (24%)
		LRR_8	645..703	CDD:290566	11/61 (18%)
		LRR_4	645..685	CDD:289563	11/43 (26%)
		LRR 18	645..666		4/20 (20%)
		leucine-rich repeat	646..669	CDD:275380	3/24 (13%)
		LRR 19	669..690		6/22 (27%)
		leucine-rich repeat	670..692	CDD:275380	5/23 (22%)
		LRR 20	692..713		0/20 (0%)
		leucine-rich repeat	693..714	CDD:275380	0/20 (0%)
		LRR 21	714..735		3/20 (15%)
		leucine-rich repeat	715..734	CDD:275380	3/18 (17%)
		LRR 22	737..758		0/20 (0%)
		leucine-rich repeat	738..764	CDD:275380	1/25 (4%)
		PP2Cc	784..1033	CDD:238083	60/293 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157		13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900