DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and Adcy5

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1592	Identity:	448/1592 - (28%)
Similarity:	699/1592 - (43%)	Gaps:	409/1592 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDK--------------------GAIALA 100
            |.:|..:||  |.....:|:|...|.|:.|.....|..:                    ||:...
Mouse     2 SGSKSVSPP--GYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQ 64

  Fly   101 QIDDLKLE---GDDDDEAVVNGEE--VDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASS 160
            |...|...   ||||::..::|::  ..|.|.|..:.....:......|.|:......||...|:
Mouse    65 QQQRLASRWRGGDDDEDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDGGRGSRRQRRGAAGGGST 129

  Fly   161 EQDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAK 225
                              |.|..|      |||....:..|:                  ||
Mouse   130 ------------------RAPPAG------GSGSSAAAAAAA------------------GG--- 149

  Fly   226 QTPLRVQSVRI-VEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAF 289
             |.:|.:||.: :|.:|..|  |..|            :||.|..:.. .|.......:.:.|..
Mouse   150 -TEVRPRSVELGLEERRGKG--RAAE------------ELEPGTGIVE-DGDGSEDGGSSVASGS 198

  Fly   290 KSGNVVK-GILCPSL-----TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWI 347
            .:|.|:. |..|.:|     :..|....|||.|..|..|..|.|| :::.|:..|..::|||
Mouse   199 GTGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAF--- 260

  Fly   348 MRRSELGPIESDDGTSMATAI----TWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNI 408
              .:...|::......:|.|:    ..:|.|..|......:|. .|:|...:..|.....:|...
Mouse   261 --HAARPPLQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL-ACYALIAVVLAVQVVGLLLPQ 322

  Fly   409 QGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATI 473
            .....:|         :|:.:|.|:..|.:||:.::..|:.|.:.::.|||:......|
Mouse   323 PRSASEG---------IWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLHTNSQ------ 372

  Fly   474 NPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSI 538
             .:.:|.|:.:|.::::..|:.|:.|.|..:..||.||.||.:.::.:..|::|.|:.::||.|:
Mouse   373 -DQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSV 436

  Fly   539 LPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDL 603
            ||..|..::::::....:   :..|:|:|:...||||||||||:|||.|||:.:||:||..||:|
Mouse   437 LPRHVAMEMKADINAKQE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNEL 498

  Fly   604 FARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVD 668
            |||||::|.:|||||:|:|||||||||...    :.|.|||.|.||.|:.||:||..||..|.|:
Mouse   499 FARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVEMGMDMIEAISLVREVTGVN 559

  Fly   669 LNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPG 733
            :|||:|||||.|.|||||.:||.||||||||.:|||||:||..||:||::|||..||..||||||
Mouse   560 VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG 624

  Fly   734 NGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGS 798
            .||.|:.:||..:::|:||
Mouse   625 CGGDRNAYLKEHSIETFLI---------------------------------------------- 643

  Fly   799 GSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRI 863
                 ::.|                              |::|:..::         :|..:|:.
Mouse   644 -----LSCT------------------------------QKRKEEKAM---------IAKMNRQR 664

  Fly   864 RNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIE 928
            .|..|
Mouse   665 TNSIG------------------------------------------------------------ 669

  Fly   929 DESTTDWIPEIPFKNL---NSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNK 990
             .:...|..|.||.|.   |.....:.|..  ..|.|:.:....|..::|:|||:.:.|...|..
Mouse   670 -HNPPHWGAERPFYNHLGGNQVSKEMKRMG--FEDPKDKNAQESANPEDEVDEFLGRAIDARSID 731

  Fly   991 EIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPR---------- 1045
            .:|.|::..:.|.|::...|:|:.:..:|.|.:.:.|..::::|:...|:.|:|.
Mouse   732 RLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLS 796

  Fly  1046 CTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVI-VSMCMLSA 1109
            |..|:..:...:||  :.||.:       .|..|:|.|.|:|..::..||  .||. :::..|||
Mouse   797 CFLLLALVVFVSVI--YACVKL-------FPTPLQTLSRKIVRSKKNSTL--VGVFTITLVFLSA 850

  Fly  1110 -IGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTP 1173
             :.:.:|.|...:|...|                               .||||::
Mouse   851 FVNMFMCNSKNLVGCLAE-------------------------------EHNITVN--------- 875

  Fly  1174 LVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVE 1238
                                                  ..|...|..|..:||...........:
Mouse   876 --------------------------------------QVNACHVMESAFNYSLGDEQGFCGSPQ 902

  Fly  1239 GQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLI----MMKFGSGD---SFSL 1296
            ..|..|||..::.:|.|::.:..|::..:.|.::.||:...|..::    :..|.:.|   :.:.
Mouse   903 PNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANA 967

  Fly  1297 VELSRLG----------MPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKS 1351
            ::.|..|          :.|.|...|::..|::.:..||:.||.|:||||:||.||..|...|:.
Mouse   968 IDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEE 1032

  Fly  1352 NRALNDTLIKNILPDHVATYYLSDE-HTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKAC 1413
            .:|.|..|:.||||..||.::|:.| ..||||.:......||||||.||.:||.| :.:| |..|
Mouse  1033 LQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1097

  Fly  1414 IRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAM 1478
            :|:|||||.||||::.|.||..:|||||:|:|||||:|||.......|:|...::.|   ||..:
Mouse  1098 LRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKAIAD---FAMKL 1159

  Fly  1479 KQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPEN 1543
            ..:::.||..:|||||:::|:..||:|:||||||||.||||||||||||||||||...|:||..:
Mouse  1160 MDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTD 1224

  Fly  1544 TAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575
            ..::|.:..|....||.:.|||||.|.|::::
Mouse  1225 MYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	66/273 (24%)
		CYCc	526..729	CDD:214485	111/202 (55%)
		Guanylate_cyc	566..753	CDD:278633	114/186 (61%)
		DUF1053	929..1020	CDD:283888	22/93 (24%)
		CYCc	1353..1554	CDD:214485	102/203 (50%)
		Guanylate_cyc	1381..1576	CDD:278633	99/197 (50%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	117/544 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194		50/254 (20%)
		CYCc	425..620	CDD:214485	111/201 (55%)
		Guanylate_cyc	461..622	CDD:278633	103/164 (63%)
		DUF1053	669..761	CDD:283888	23/154 (15%)
		CYCc	1037..1238	CDD:214485	102/203 (50%)
		Guanylate_cyc	1063..1257	CDD:278633	99/197 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710