Protein Alignment Ac78C and Adcy2

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_705762.2
• Gene: Adcy2 / 210044
• MGIID: 99676
• Length: 1095
• Species: Mus musculus
• Alignment Length: 1322
• Identity: 410/1322 - (31%)
• Similarity: 641/1322 - (48%)
• Gaps: 303/1322 - (22%)

  Fly   312 LERS----YLTYTHRQRQKSLIIVNVVDFVLKIV----LAFVWIMRRSELGPIESDDGTSM---- 364
            |:||    |.:|....:|..||:     |:|.||    ||.:.:.  ..|| :|.:|..:.
Mouse    30 LQRSRDWLYESYYCMSQQHPLIV-----FLLLIVMGACLALLAVF--FALG-LEVEDHVAFLITV 86

  Fly   365 --ATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFV----GQGVGFADREY 423
              |.||.:::.     :.:|....::    ..|...::..|:.....|::    |..|...|:
Mouse    87 PTALAIFFAIF-----ILVCIESVFK----KLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQ-- 140

  Fly   424 LVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATIN-PECVLFQIFANFI 487
             |.:.||:|||.|.|||..::..::...:|:|.|..|:::    :..||.. .|.:.:||.||.|
Mouse   141 -VSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSV----YLSATPGAKEHLFWQILANVI 200

  Fly   488 LYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY 552
            ::...|:||.|.|:|.:...:..:.:|...::.:.:.|.|.::.::||.|:||..:..::::|:.
Mouse   201 IFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEII 265

  Fly   553 ------KGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIA 611
                  |.........|:.|||....|||||:|||.|||.|||..|..:||.:||:||.:||:||
Mouse   266 QRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIA 330

  Fly   612 EDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIH 676
            ::|.|:|:|:|||||||||....    :.|:||...|:.||.|.:|||.||..|.||:|||:|:|
Mouse   331 KENECMRIKILGDCYYCVSGLPI----SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVH 391

  Fly   677 SGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNH 741
            ||:|:|||:|.:||.:||||:||.:|||||:||:|||||||..||:.||.||:||.|:|..||.:
Mouse   392 SGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPY 456

  Fly   742 LKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTA 806
            ||...||||.:     :.||..  .||..||.....|.
Mouse   457 LKQHLVKTYFV-----INPKGE--RRSPQHLFRPRHTL--------------------------- 487

  Fly   807 TGNDGASIDG--RSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGV 869
               |||.:..  |...|..:..  |.:|...|..:                   ||....||
Mouse   488 ---DGAKMRASVRMTRYLESWG--AAKPFAHLHHR-------------------DSMTTENG--- 525

  Fly   870 MGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTD 934
                                                                       ..||||
Mouse   526 -----------------------------------------------------------KISTTD 531

  Fly   935 WIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQ-INSNKE-IRREYL 997
                :|.        |.:...:..:.||...:    ..:||::|.:.|.|. ||:.|: ::.|.:
Mouse   532 ----VPM--------GQHNFQNRTLRTKSQKK----RFEEELNERMIQAIDGINAQKQWLKSEDI 580

  Fly   998 NPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTF 1062
            ...:|.|.:|:.|:::.......|:..:.|..:|::.:.:.|::::|:.:  |:..|.|...|:.
Mouse   581 QRISLFFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTS--ILGFSFGAAFLSL 643

  Fly  1063 CCVLVMAEEFPG-LPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADE 1126
            ..:|.:.  |.| |.:|.|..||.|                 :.:|.:.|::.
Mouse   644 IFILFVC--FAGQLLQCSKKASASL-----------------LWLLKSSGIIA------------ 677

  Fly  1127 HSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTL 1191
             :|      |:..||:|  .....:.|:..:.:...:|.                 |:|....|.
Mouse   678 -NR------PWPRISLT--IVTTAIILTMAVFNMFFLSN-----------------SEETTLPTA 716

  Fly  1192 NALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLV 1256
            ||...|::.|..|       |...|:.:|..|                     .|.:::.:|.|:
Mouse   717 NASNANVSVPDNQ-------TAILHARNLFFL---------------------PYFIYSCILGLI 753

  Fly  1257 SLATALKLYYLVKAL-MALAMVAFYTTLIMMKFGSGDSFSLVELSRLGM-----PLG-VQMLILL 1314
            |.:..|::.|.:|.| |.:|:|.:...|:.......|::|.|...|.|:     .:| |.:.|..
Mouse   754 SCSVFLRVNYELKMLIMMVALVGYNIILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFF 818

  Fly  1315 ISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-HT 1378
            |:.||:    .|..|...||||:||.:.::|...:::...||..|::|:||.|||.::|:.. ..
Mouse   819 ITLLVL----GRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKN 879

  Fly  1379 DELYSKMHNLCGVMFASIPNFQDFYSE-DID-NGKACIRILNEIICDFDELLEEPRFASVEKIKT 1441
            :|||.:.::...|||||||:|::||:| |:: .|..|:|:|||||.|||:||.:|:|:.||||||
Mouse   880 EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKT 944

  Fly  1442 VGATYMAAAGL----NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSG 1502
            :|:|||||.||    :.||.: ..|.....:..:||||:|:..||:.||..:||:|:|||||..|
Mouse   945 IGSTYMAATGLSAVPSQEHAQ-EPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHG 1008

  Fly  1503 PLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKG 1567
            |:::|||||:||.||||||||||||||||||...::||.|.|:.:|.:.||||..||.|.|||||
Mouse  1009 PVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKG 1073

  Fly  1568 MMTTFYVH---PKGISESQLIS 1586
            .:.|::|:   .:.:|:|.|.|
Mouse  1074 DLKTYFVNTEMSRSLSQSNLAS 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	64/257 (25%)
		Guanylate_cyc	566..753	CDD:425528	108/186 (58%)
		Adcy_cons_dom	929..1021	CDD:461877	21/93 (23%)
		Guanylate_cyc	1381..1576	CDD:425528	109/203 (54%)
Adcy2	NP_705762.2	AcyC	54..474	CDD:441717	168/449 (37%)
		Guanylate_cyc	285..469	CDD:425528	108/192 (56%)
		Adcy_cons_dom	499..604	CDD:461877	29/203 (14%)
		Guanylate_cyc	882..1081	CDD:425528	108/199 (54%)