DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gcy-34

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	98/381 - (25%)
Similarity:	163/381 - (42%)	Gaps:	79/381 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1255 LVSLATALKLYYLVKALMALAMVAFYTTLI--MMKFGSGDSFSLVELSRLGMPL--GVQMLILLI 1315
            ::.|:|...:.||...         |.|.|  :|:||         :....|||  ..:.||||
Worm   345 MMMLSTKKHIIYLCSP---------YVTSINELMQFG---------MRLTAMPLHDATRDLILL- 390

  Fly  1316 SFLVMVCYHARL--VEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHT 1378
                   ...||  |||..:|: ...||.|.....::..|...|:::|::||..:|...||.||.
Worm   391 -------NQQRLSDVEVNLQLE-ANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQLLSGEHL 447

  Fly  1379 DELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVG 1443
            :....:    ..|||..:|.||...  .:...|..:::|||:....|.::.   ...|.|::||.
Worm   448 EPCEYE----ATVMFCDLPAFQQII--PVCQPKNIVKLLNEVFFKLDRIVV---LRGVYKVETVS 503

  Fly  1444 ATYMAAAGL---NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNN--FQLRVGICSGP 1503
            .:||..:|:   ..||        .:::|.:   |..|..:...:. |..|.  |.||:|:.||.
Worm   504 DSYMTVSGIPDYTSEH--------AENMCHV---ALGMMWEARSVM-DPVNKTPFLLRIGLHSGT 556

  Fly  1504 LVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRG-YTCVKRGEIAVKGKG 1567
            :::||:|.:.|.|.::|.||.:||:|:|.|...::|....|.......| :....||.|.|||:|
Worm   557 IIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRG 621

  Fly  1568 MMTTFYV-------------HPKGISESQLISPVRMPAGIPLAQTPNLQRQTSHHG 1610
            .:.|:::             |.:.::.:.:.....:...|..|||      ..|.|
Worm   622 DVETYFLMRSLKKSIWEITDHERDVNVNSIEGYEELEIFIENAQT------VKHDG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	57/206 (28%)
		Guanylate_cyc	1381..1576	CDD:278633	55/213 (26%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002
		HNOBA	224..441	CDD:285003	32/122 (26%)
		CYCc	421..609	CDD:214485	57/208 (27%)
		Guanylate_cyc	453..629	CDD:278633	55/196 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810