Protein Alignment Ac78C and gcy-25

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_001294116.1
• Gene: gcy-25 / 191653
• WormBaseID: WBGene00001549
• Length: 1034
• Species: Caenorhabditis elegans
• Alignment Length: 1280
• Identity: 240/1280 - (18%)
• Similarity: 431/1280 - (33%)
• Gaps: 431/1280 - (33%)

  Fly   475 PECVLFQIFANFILYTAINVAGMYTKYL---------TDRGQRLAFIETHKA-MEHKKESEKELQ 529
            |.|..|....|     |.|:...|:..|         |....||| :..||. :.....|.||.:
 Worm    52 PSCHNFNGLEN-----AANLNYQYSVDLLIGAACDEETQTVSRLA-LRWHKLYLSSAPLSTKEKE 110

  Fly   530 RTQKLLDSILPN-------IVNNQIRSEMYK--GTDPTVETQFNKLYVYPM-----DNVSI-LFA 579
            .|...|.   |:       ::....:|..:|  |...:.||::....:|.|     |::.| :|.
 Worm   111 STTIALK---PHSLAGTAEVILAMCKSMKWKEIGIIYSEETKYTAHAIYDMLAEQEDDLKINVFL 172

  Fly   580 DIKGFTELASKT-----SAQQLVKILNDL-FARFDRIAEDN--HCLRVKLLG-DCYYCVSQFESD 635
            :..|.    |.|     ||:.|:..|..| .::|.:..::|  ..|...::. ||    ::.|..
 Worm   173 ETDGL----SNTYTILHSARALISFLTTLDLSKFFKTLKENAFRPLEFSIVHVDC----NKSEIS 229

  Fly   636 NWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVI 700
            |:.|..|:   :.....:.|.|.:..:|:.||.|                 .|..|.|:...:..
 Worm   230 NFYTYLDN---NAGEEPNPISAARLRKLYRHVAL-----------------LKNSHDDMEKTEEF 274

  Fly   701 IANHMESGGIPGRVHISEATLKC-----LNDAYEVEPGNGGCRDNHLKMLNVKTYL---IKRTEP 757
            ...:   |.:|... :.:|.:.|     ||: |....||       |.::....||   :..||
 Worm   275 AKKY---GLVPSYT-LYKALILCDGLQLLNN-YTAPRGN-------LSIVQQLPYLWNHVTNTE- 326

  Fly   758 LRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASI-------- 814
                                                    :....|....||||..:
 Worm   327 ----------------------------------------TQGYSGPVFIGNDGVRLPYYEMHMW 351

  Fly   815 -DGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGG 878
             ||:::..|                        |..|           |..:.||
 Worm   352 RDGKAVHVA------------------------NVKP-----------RESDYCG---------- 371

  Fly   879 GGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQN---------LAEAIDGKGLII------- 927
                  |..|.:....:.|:||...|.|....|...|         :..||....|:|
 Worm   372 ------GNMTKNCYEFLPSSPLLEDLPPYTSDCGYDNNLCSDFHVFMIAAIVFSILLIPMAIAFY 430

  Fly   928 --EDESTTDWIP-EIPFKNLNSPEDGLNRADSILVDTKEDHRVSV-AVLDEEIDEF--------- 979
              ..|.....:| .:|..:::..::|.:.:.|..|.|....|.|. ::....:.|.
 Worm   431 LQRKEHLIQQMPWRVPLDSISFDDNGGSLSASRRVSTISTARASYSSIFSGNVAEHAIVNKQKVS 495

  Fly   980 IEQNIQ-------------INSNKEIRREYLNPWT-------------LKFKDKSQEQKFCQLRE 1018
            :::::|             :|..|.:....:||:|             .:|..:...:....::|
 Worm   496 VKRHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELIVMWQFTTRYSLEDLIFVKE 560

  Fly  1019 DMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSV---GTVILTFCCV----LVMAEEFPGLP 1076
            ..|..|....|:..|...:          ..|...|:   |.:.|:.|.|    :|...:| |:.
 Worm   561 QKFGRNFQSTFIKHIVHGI----------NYIHNSSIKVHGALYLSNCVVDSYWVVKLTDF-GIK 614

  Fly  1077 RCLK--TNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSN 1139
            ..||  ||     |:.                       |.|||.:...| .|.::|::...:.:
 Worm   615 GILKERTN-----HKE-----------------------LAPSSAFDVDA-IHYKYLQLAPEHIS 650

  Fly  1140 ISMTEKE-----FKLNVY-LSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNL 1198
            ..:.:.|     .:.::| |:..|:..:....|.:             ...|.::...:.|:...
 Worm   651 AILEKLEEPRGTVEGDIYQLAMCIYQILFYMRPFA-------------ERQESIKELAHLLSSQS 702

  Fly  1199 TPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALK 1263
            |.||      :.....|:|.::..|     |::|       ||         |:
 Worm   703 TAPL------HPKVPEGNSFTMRLL-----SIIQ-------QC---------WL----------- 729

  Fly  1264 LYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLV 1328
              |...|..||..:   |..:..:||.....:|::          ||:.::..      |.|.|.
 Worm   730 --YKPAARPALIKI---TDAVNREFGQDVKGTLID----------QMIEMIDE------YSANLE 773

  Fly  1329 EVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMF 1393
            ::.:        :..|||   :.:.::.:.|:..:||..||....|.:   .:..:.|:...::.
 Worm   774 QIVA--------ERTREL---EQDMSVTENLLYQLLPKSVADSIRSGK---TVVPEQHSSVTLLV 824

  Fly  1394 ASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGL----NH 1454
            ..:..|..|....|.  ...:..|.|:...||.::::.:   ..|::.||..|:..:|:    ..
 Worm   825 VDVCQFTKFCEAFIP--VHILETLQELYSSFDNIVQKNK---AFKVENVGDAYLICSGIPEMSGF 884

  Fly  1455 EHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIW 1519
            .|||        .:|. :........|..::.....:..|:::||.||.:.:|::|:..|.:.|:
 Worm   885 RHLR--------EICK-ISLKLQAFMKTFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIF 940

  Fly  1520 GNTVNVASRMDSTGENWRVQVPENTAELLCSR--GYTCVKRGEIAVKGKGMMTTFYVHPKGISES 1582
            |:|||:|.||.|||....:|:.|.||..|..:  .:...:||.|.|||||...||::    ..|.
 Worm   941 GDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWL----TGEK 1001

  Fly  1583 QLISPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQA--SKR 1625
            .:                 ::||:|.....|.:.|.:.:|  ||:
 Worm  1002 DI-----------------MRRQSSRSSCISQIKFELDEADNSKK 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	21/92 (23%)
		CYCc	526..729	CDD:214485	47/231 (20%)
		Guanylate_cyc	566..753	CDD:278633	43/209 (21%)
		DUF1053	929..1020	CDD:283888	18/127 (14%)
		CYCc	1353..1554	CDD:214485	48/206 (23%)
		Guanylate_cyc	1381..1576	CDD:278633	52/200 (26%)
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346	42/190 (22%)
		PKc_like	473..746	CDD:304357	58/368 (16%)
		SPS1	474..>736	CDD:223589	55/354 (16%)
		HNOBA	<764..805	CDD:285003	11/57 (19%)
		CYCc	790..976	CDD:214485	48/202 (24%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	52/204 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810