DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gcy-23

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	260	Identity:	75/260 - (28%)
Similarity:	126/260 - (48%)	Gaps:	47/260 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1342 AER----ELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELY------SKMHNLCGVMFASI 1396
            |||    |..|:::     |.|:..:||.:||         :||.      :|..::..|||:.|
Worm   834 AERTGMLEEANVRA-----DKLLGQLLPKYVA---------NELKMGRSVPAKTFDMATVMFSDI 884

  Fly  1397 PNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGL----NHEHL 1457
            ..|....|.  ......:.:||.|...||:.:.:   ....|::|:|..||..:|:    .:||:
Worm   885 VGFTTICSS--STPLEVVSMLNSIYSKFDDAINK---HGSYKVETIGDAYMIVSGIPEENGNEHI 944

  Fly  1458 RLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNT 1522
            |        ::|: ......:..|..||........::|:||.:|.:.:||:|...|.|.::|:|
Worm   945 R--------NICN-TALELMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDT 1000

  Fly  1523 VNVASRMDSTGENWRVQVPENTAELLCSRGYT---CVKRGEIAVKGKGMMTTFYVHPKGISESQL 1584
            |||||||:||.|..::|:.:...: .|.|.|:   ...||.:..||||.:|::::..|. ||||:
Worm  1001 VNVASRMESTSEPEKIQMSQEARD-FCVRYYSEFQITLRGTVEAKGKGPVTSYWLLGKQ-SESQM 1063

Fly 1585 1584
Worm 1064 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	57/210 (27%)
		Guanylate_cyc	1381..1576	CDD:278633	58/207 (28%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894
		HNOBA	<817..863	CDD:285003	11/42 (26%)
		CYCc	842..1035	CDD:214485	59/221 (27%)
		Guanylate_cyc	869..1056	CDD:278633	57/201 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810