DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gcy-21

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	291	Identity:	83/291 - (28%)
Similarity:	143/291 - (49%)	Gaps:	43/291 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 SLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTL 1359
            ||.::.|...||.:.:...::..:|     :.:.:.|.:|:   |:.|||. ..::..:|.::.|
Worm   870 SLHQIKRKLKPLTIGLKRTIMDNMV-----SMIEKYTDKLE---KDIAERN-EELEGEKAKSEAL 925

  Fly  1360 IKNILPDHVA-TYYLSDEHTDELYSKMHNLCGVMFASIPNFQDF--YSEDIDNGKACIRILNEII 1421
            :|.:||:.|| :..|....:.|.:..    |.|.|:..|.|.:.  .|:.||    .::.||::.
Worm   926 LKMMLPEVVADSLKLGSNVSAESFEN----CTVFFSDCPGFVEMSATSKPID----IVQFLNDLY 982

  Fly  1422 CDFDELLEEPRFASVEKIKTVGATYMAAAGL-----NHEHLRLRGETSEDSVCDLVEFAFAMKQK 1481
            ..||.::::   ..|.|::|:...||.|:||     ||.    .||        :.....|:.:.
Worm   983 TVFDRIIDQ---FDVYKVETIADAYMVASGLPVPNGNHH----AGE--------IASLGLALLKA 1032

  Fly  1482 LEEINGDAFNN--FQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENT 1544
            :|........|  .:||:|:.|||.|:||:|.:.|.|.::|:|||.||||:|.|...|:......
Worm  1033 VESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTA 1097

  Fly  1545 AELLCS-RGYTCVKRGEIAVKGKGMMTTFYV 1574
            .|:|.. .||...:||.:.:||||...|::|
Worm  1098 KEILDQLGGYEIEERGIVEMKGKGKQMTYFV 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	62/211 (29%)
		Guanylate_cyc	1381..1576	CDD:278633	62/204 (30%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822
		PK_GC	612..881	CDD:270894	3/10 (30%)
		HNOBA	<890..938	CDD:400168	14/56 (25%)
		Guanylate_cyc	944..1130	CDD:306677	63/208 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810