Protein Alignment Ac78C and gcy-19

DIOPT Version :9

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_001348702.1
• Gene: gcy-19 / 191650
• WormBaseID: WBGene00001544
• Length: 1187
• Species: Caenorhabditis elegans
• Alignment Length: 1527
• Identity: 282/1527 - (18%)
• Similarity: 491/1527 - (32%)
• Gaps: 611/1527 - (40%)

  Fly   422 EYLVWYIL---FVIFVP----YAML--------PLP---------------------LKWCVVGG 450
            |||::.:|   |:.|:|    ||.:        |:|                     :.|.:.||
 Worm     2 EYLLFLLLFAGFLTFLPRFLIYAQITSSTTTTTPVPAANRRTIRVGVAAVQTTELDSIGWPMSGG 66

  Fly   451 TITASCHLAVITIIKLQHG--------EATIN-PECVLFQIFANFILYTAINVAGMYTKYL---- 502
            .|.       :.|.||:..        |.|:| .||       :..|..|:.:..|.||.|
 Worm    67 AIN-------MAIQKLRDDGFIAPFDFEVTVNYTEC-------DRSLGAAVGMEFMRTKRLDVVI 117

  Fly   503 ----TDRGQRLAFIETHKA---MEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVE 560
                .|..:.:|.:.|:.:   :.....::.:...|::.  ..|.||:.|            ::.
 Worm   118 GPPCRDPMEIMATMATYYSTPMLGWGLVTDSKFTDTERY--PYLTNIMAN------------SLS 168

  Fly   561 TQFNKLYVYPM---DNVSILFADIKGFTELASKTSAQQL-VKILNDL---FARFDRIA------- 611
            ..|:.:.:..|   |.|::::.:           |||.. :.::||:   ...:|..|
 Worm   169 LGFSLVKLLEMMEWDRVALVYEE-----------SAQDYPLSVINDVETAINEYDTFAVNVVVKQ 222

  Fly   612 -------EDNHCL----RVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHT 665
                   .|...:    |:||  .|...||.|:     |.|        |....:|.|....:..
 Worm   223 ALPGGDLNDAQYISVLNRIKL--RCRIIVSVFQ-----TAP--------TRRRYLKMIDQQGMAN 272

  Fly   666 HVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDA--- 727
            ...:::.:|:.|       :|..|                :|.|      :::..|.||:..
 Worm   273 EEYVHILLGLRS-------IGFGK----------------QSAG------LTKCELNCLSSGLAP 308

  Fly   728 -YEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLR-----PKRRFGTRSSAHLAGSVATAAPPCATP 786
             :::.|.:|  .::.||....:..::...:.:.     |...:....:.:....|......||||
 Worm   309 FWDIAPDDG--LNDRLKQAATRMLVMDLPDTMDLSTDVPDINYLNTFTMNCGAVVVNPPVSCATP 371

  Fly   787 TALPKSISASGSGS--------IGGVTATG---------NDGASIDGR-SLEYA---ATIAVPAQ 830
            ..:..|.|...:.:        :.|:..|.         ||...|:|. .|.:|   ..:::.|.
 Worm   372 ACINASTSPPSAFARSLHDVFYLYGLAITNLYNQDPAYLNDIDKINGALQLNFAGLTGEVSINAN 436

  Fly   831 Q---PTQLLQQQQKK--NISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVS 890
            .   |..:|.....|  ..|..:|...:.|.|..|....|...:....||........||.:...
 Worm   437 NSRVPKLMLYALNDKYDQASFMNLTYSLNGGASVSLAYTNEASLWYWYGGKRPLSVPVCGFAGTD 501

  Fly   891 SPTAMMSAPLEVQLRPRNGACSIQNLAEAIDG------------------KGLIIEDESTTDWIP 937
            .|.:.:.         :.||     |..||.|                  :..:..|....:|
 Worm   502 CPQSFVD---------QYGA-----LVFAIGGVLIFAMLFVITCFFYVMRQKRLERDRIDAEW-- 550

  Fly   938 EIPFKNLNSP---------EDGLNRADSILVDTKE---DH---RVSVAVLDEE------------ 975
            :||...|.:|         :..|....|.:.||.:   |:   ..|:..||:|
 Worm   551 QIPLVKLQAPPKRDKERMSKRSLQSGPSNITDTSKMTFDNTFSNYSIFYLDKEPVLSTAHPASNL 615

  Fly   976 ----IDEFI------EQNIQINSNKEIRR-----EYLNPWTLKFKDKSQEQKFC---QLREDMFR 1022
                .|.|:      .:|:    ||.:..     |||..|           |.|   .|::.:.:
 Worm   616 IRTDYDTFVRLRKLDHENV----NKFVGMSIDGPEYLAVW-----------KLCMRGSLQDIIGQ 665

  Fly  1023 SNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLV 1087
            .|    |.|..|.:                         ||.:..|||....|     .||...|
 Worm   666 GN----FSIDPFFM-------------------------FCVIRDMAEGLKYL-----HNSFLHV 696

  Fly  1088 HQRQRRTLFICGVIVS---MCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKL 1149
            |...|...    |:|:   ...|:..||         ||..|..:           .|..::..:
 Worm   697 HANLRSGT----VLVNESWQAKLTDFGL---------GTLAEEKK-----------PMKRRQLWM 737

  Fly  1150 NVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTN 1214
                                             :.|.:|.||      |...:.:|...|:|...
 Worm   738 ---------------------------------APEVIRGTL------LPHQIEKSADIYSLAVI 763

  Fly  1215 GHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAF 1279
            ...|    |:..:|..|....|                       |..::.|.:|.
 Worm   764 ASEV----LTRKEAWNMAERKD-----------------------TVDEIVYRIKK--------- 792

  Fly  1280 YTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQ-AE 1343
                      .|.:....||...|:.:...:||     |:..|               |.|: |:
 Worm   793 ----------GGPNAPRPELDMDGVEINHNLLI-----LIRDC---------------WSEEPAD 827

  Fly  1344 RELTNMKSNRALNDTLIKNILP------DHVATYYLSDEHTDELYSKMHN--------------L 1388
            |...::..|      |:||::|      |||  :.:.:::|..|..::.:              |
 Worm   828 RPSADVICN------LLKNMMPKKGNLMDHV--FNILEDYTTNLEVEVEDRTKELTAEKKKADVL 884

  Fly  1389 CG--------------------------VMFASIPNFQDFYSEDIDNGKAC-----IRILNEIIC 1422
            .|                          |.|:.:..|....::       |     :.:||::..
 Worm   885 LGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAK-------CSPFQVVNLLNDLYS 942

  Fly  1423 DFDELLEEPRFASVEKIKTVGATYMAAAGL----NHEHLRLRGETSED--SVCDLVEFAFAMKQK 1481
            :||.::||   ....|::::|..|:..:||    .:.|::...|.|.|  |.|...:.....::|
 Worm   943 NFDAIIEE---HGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLPREK 1004

  Fly  1482 LEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAE 1546
            :|           ||:|:.|||.|:||:|...|.|.::|:|||.||||:|.|:...:.:...:..
 Worm  1005 VE-----------LRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYT 1058

  Fly  1547 LLCS---RGYTCVKRGEIAVKGKGMMTTFYVHPK-----GISESQLISPVRMPAGIPLAQTPNLQ 1603
            ||..   ..|....||::.:||||:|.||:|..:     |:|
 Worm  1059 LLMKHYPNQYNTASRGDVIIKGKGVMETFWVFERNNQFMGVS----------------------- 1100

  Fly  1604 RQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTP--SPQIR--------RGHRGSTFSSVRLSQK 1658
               |:.|         .|:.|::|....:|..||  :|.:.        |..:..:.||..||::
 Worm  1101 ---SNSG---------YQSDKKATNNGSSPESTPPSTPPMHEVKANSPVRHRKPPSPSSPTLSKR 1153

  Fly  1659 STTVNP--------VRRNTTRVRGRSYRQKKS 1682
            |  |:|        :....|....|.:|::::
 Worm  1154 S--VSPIMEAKARDIHNEETEALYRQFRRQET 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	37/184 (20%)
		CYCc	526..729	CDD:214485	38/231 (16%)
		Guanylate_cyc	566..753	CDD:278633	36/215 (17%)
		DUF1053	929..1020	CDD:283888	27/135 (20%)
		CYCc	1353..1554	CDD:214485	58/260 (22%)
		Guanylate_cyc	1381..1576	CDD:278633	61/248 (25%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	85/506 (17%)
		PKc_like	571..841	CDD:328722	76/453 (17%)
		CYCc	876..1065	CDD:214485	49/209 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810