DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and gcy-14

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	947	Identity:	194/947 - (20%)
Similarity:	328/947 - (34%)	Gaps:	337/947 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   823 ATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRR--IRNGCGVMGGAG----GTGGG-- 879
            :|..|||....||........::||      ..:..|..|  ::||..|:...|    |.|||
Worm   341 STYKVPATYAGQLFDAFYAYGVALN------RSLTQDPTRANLKNGSFVLSDIGMSFQGVGGGTV 399

  Fly   880 -----GTGPCGMSTVSSPTAM---MSAPL-----EVQLRP----RNGACSIQNLAEAIDG----- 922
                 ||....:...:..|::   ::|.|     ||:..|    .....|::.||..|.|
Worm   400 TLDDTGTRIVQVYMFALNTSLLPYLAASLVINGSEVEYTPFYKSEADLWSVRPLARPICGFSGLE 464

  Fly   923 ----------------------------KGLII------EDESTTDWIPEIPFKNLNSPEDGLNR 953
                                        .||:.      ::....|.:.::||..|...: ..::
Worm   465 CPPDFVKEYLVYTIIAAVIVVLALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQ-SKSK 528

  Fly   954 ADSILVDTKEDHRVSVAVLDEEIDE-------FIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQ 1011
            |::.:.........|..:..|...|       :.:|:|......::        .|:| |..|:.
Worm   529 AEASMHSFASGPSTSTKITVESRSETINFIFYYYQQDILAAMKHDL--------ILQF-DAEQKA 584

  Fly  1012 KFCQLR----EDMFRSNMLC-----VFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLV 1067
            :|.|:|    :::.:...||     :|.:|.|           |:|    .|:..||
Worm   585 EFRQMRNFDNDNLNKFIGLCLDGPQLFSLWRF-----------CSR----GSLSDVI-------- 626

  Fly  1068 MAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLR 1132
                         :.|:     .|..:.|:..:|..:    :.||:..           |:.||:
Worm   627 -------------SKSS-----MQMDSFFMFSLIRDI----SNGLLFI-----------HNSFLK 658

  Fly  1133 MVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVD----ITSSGPSDEFVRSTLNA 1193
                                    .|.::|       ....|:|    |..||...:.||:..|.
Worm   659 ------------------------CHGHLT-------SRCCLIDDRWQIKISGYGLKSVRTFENP 692

  Fly  1194 LTLNL--TPP----------LPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEY 1246
            ...:|  |||          ||:.           .:....:..|:.....|:.|:|.:...|:.
Worm   693 KKEDLLWTPPENLRNENEERLPEG-----------DIYSFGIICSEILTRSSAFDLENRKEKPDV 746

  Fly  1247 LVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFG------SGDSFSLVELSRLGMP 1305
            ::                 |.||                 |.|      |.|:...||::.
Worm   747 II-----------------YQVK-----------------KGGHNPMRPSLDTGETVEINP---- 773

  Fly  1306 LGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHV-- 1368
                    .:..|:..|:..|..|..|      .||....|..|:..|       |:.|.|||
Worm   774 --------ALLHLIRDCWTERPSERPS------IEQVRGHLNGMRDGR-------KSNLMDHVFN 817

  Fly  1369 --ATY--YLSDE---HTDELYSKMHNLCGVMFASIP----------------NFQD---FYSEDI 1407
              .||  .|.:|   .|.||..:......:::..:|                .|:.   |:|:.:
Worm   818 MLETYASTLEEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVV 882

  Fly  1408 D----NGKA----CIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNH----EHLRLR 1460
            .    .||.    .:.:||::...||.::|:   ..|.|::|:|..|:..:||.|    ||:|..
Worm   883 QFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQ---NDVYKVETIGDGYLCVSGLPHRNGNEHIRHI 944

  Fly  1461 GETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNV 1525
            ...|...:..| ||........|.||        ||:||..|.:|:||:|...|.|.::|:.||.
Worm   945 ARMSLGFLSSL-EFFRVQHLPSERIN--------LRIGINCGSVVAGVVGLTMPRYCLFGDAVNT 1000

  Fly  1526 ASRMDSTGENWRVQVPENTAELLCS--RGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPV 1588
            ||||:|.|:..::.|.....::|..  .|:....|||:.:||||:|.|:::    :.|...||
Worm  1001 ASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGKGVMETYWL----LGEQSRIS-- 1059

  Fly  1589 RMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKR 1625
             :.|..|..:||...|:.|.. |.|.::..|.:.:::
Worm  1060 -VSAQAPREKTPEPPRRQSVR-SISPIIEKMSEETQK 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888	17/101 (17%)
		CYCc	1353..1554	CDD:214485	65/242 (27%)
		Guanylate_cyc	1381..1576	CDD:278633	62/227 (27%)
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347	21/87 (24%)
		ANF_receptor	43..418	CDD:279440	20/82 (24%)
		PKc_like	535..800	CDD:304357	68/423 (16%)
		HNOBA	<817..860	CDD:285003	8/42 (19%)
		CYCc	839..1031	CDD:214485	52/203 (26%)
		Guanylate_cyc	866..1053	CDD:278633	60/202 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810