DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gcy-13

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	223	Identity:	66/223 - (29%)
Similarity:	114/223 - (51%)	Gaps:	18/223 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 IETHKAM--EHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNV 574
            :|.|.:.  :..:|..|||...:|..|.:|..::..|:...:..|  .:||.:       ..::|
Worm   788 LEKHASSLEDEVQERMKELVEEKKKSDILLYRMLPQQVAERLKLG--QSVEPE-------AFESV 843

  Fly   575 SILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKT 639
            :|.|:|:.|||.||:|::..|:|.:||||:..||.|.|.|...:|:.:||.|..||.....|
Worm   844 TIFFSDVVGFTVLANKSTPLQVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRN--- 905

  Fly   640 RPDHAVCSVETGLHMIKAIKDVRLHTHV---DLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVII 701
            ..:|........|.::.:::..:: .|:   .:.:|||:||||.:.||:|.....:.::.:.|..
Worm   906 GTEHVANIANMSLELMDSLQAFKI-PHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNT 969

  Fly   702 ANHMESGGIPGRVHISEATLKCLNDAYE 729
            |:.|||.|.||.:|:|......|...|:
Worm   970 ASRMESNGKPGFIHLSSDCYDLLTSLYK 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	10/40 (25%)
		CYCc	526..729	CDD:214485	62/205 (30%)
		Guanylate_cyc	566..753	CDD:278633	53/167 (32%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347
		ANF_receptor	13..368	CDD:279440
		PKc_like	548..770	CDD:304357
		HNOBA	<797..829	CDD:285003	8/31 (26%)
		CYCc	808..1000	CDD:214485	60/203 (30%)
		Guanylate_cyc	835..1022	CDD:278633	55/174 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810