DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac78C and gcy-3

DIOPT Version :9

Sequence 1:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster
Sequence 2:NP_496037.1 Gene:gcy-3 / 191641 WormBaseID:WBGene00001530 Length:1140 Species:Caenorhabditis elegans


Alignment Length:1427 Identity:278/1427 - (19%)
Similarity:467/1427 - (32%) Gaps:533/1427 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   363 SMATAITWSVCCGIANMAICFL---GYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYL 424
            :.:.:|.|:||.|...:||..|   ||    ..|:                         |.||.
 Worm    45 TQSASIGWNVCGGAVPLAIERLKQAGY----VTNF-------------------------DFEYY 80

  Fly   425 VWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILY 489
            |.|                ..|.:..|:...     |..:|....:..|.|.|       :..:.
 Worm    81 VEY----------------TECDLASTVRTG-----INFLKNLEVDVIIGPPC-------SEAIR 117

  Fly   490 TAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKL--LDSILPNIVNNQIRSEMY 552
            |...:|.:|.|.:...|    |:           |:.:|....:.  |.::||            
 Worm   118 TMATLATLYKKPVLGWG----FV-----------SQADLSDMTRFPYLITVLP------------ 155

  Fly   553 KGTDPTVETQFNKLY-VYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHC 616
              |..|:....:||. :|..|.|::|:          .|:.......::||:...|:  ....:.
 Worm   156 --TSQTLGYAASKLLELYKWDKVALLY----------YKSEVNHCGGVMNDVETTFN--DPSTYS 206

  Fly   617 LRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGL---------------HMIKAIK---DVRL 663
            :::.|..:.      ..|||..|  :..:.||:|..               :|||..:   |...
 Worm   207 IQIVLKAEI------DASDNVTT--NAVISSVKTRARIILWCAQLGSEKRDYMIKISQLGLDTDE 263

  Fly   664 HTHVDLNMRIGIHSGSVMCGV---LGNKKWHFD----VWSNDVIIANHMESGGIPGRVHI----- 716
            :.||.::||      |:..||   :|...:...    ||.:...:.:.:|:....|..::     
 Worm   264 YVHVLISMR------SIGFGVQTFVGKTTFKLSGLTPVWESFSNVTDGLENVAKRGATNVLVIDL 322

  Fly   717 -SEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAA 780
             ||.:.|...|..:            ..:|||                              ...
 Worm   323 NSEVSDKAYLDYMQ------------RNILNV------------------------------VKL 345

  Fly   781 PP--CATPTALPKSISASGSGS----------IGGVTAT---GNDGASIDGRSL---EYAAT--- 824
            ||  |:|...:  |.:|:|.|:          :.|:..|   ..|.|..|..|.   ::..:   
 Worm   346 PPLNCSTVDCV--SSTATGMGAYARHLFDVVYLYGIALTRVNSTDSAVYDDMSKLIPQFVTSFNG 408

  Fly   825 ----IAVPAQQPTQLLQQ-----QQKKNISLNSLPNVVEG--VAMDSRRIRN-GCGVMGGAGGTG 877
                :|:........|.|     :|.:..||.:| :..:|  ||..|....| ...|....||..
 Worm   409 MTGLVAINQNLSRMPLYQLYGLDEQYEQTSLMNL-SFADGTTVATISLAYSNESSAVWHFWGGIR 472

  Fly   878 GGGTGPCGMSTVSSP---------TAMMSAPLEVQLRPRNGAC---SIQNLAEAIDGKGLIIEDE 930
            ...|..||....|.|         ...:.|.:.:.:...|..|   .|:|..|.        :..
 Worm   473 PLATPICGFLGNSCPLPFWEQYGILIFVGAGVFLIMITTNLICFLFMIKNRREE--------QAR 529

  Fly   931 STTDWIPEIPF--------KNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQIN 987
            ..::|  :|||        |:..:.:..|..|.|.:..   :.:||..      .||.| |.:: 
 Worm   530 INSEW--QIPFVKLRELERKSKGTSKRSLQSAPSTITG---ESKVSTG------SEFCE-NYEV- 581

  Fly   988 SNKEIRREYLNPWTLKFK----DKSQEQKFCQLRE-DMFRSNMLCVFVIWIFMVLCQVIIIPR-C 1046
              |...::.:  .|:||:    :|:...||.:||: |....|..    |.:.:...|.|.:.: |
 Worm   582 --KMFEKDMV--LTMKFQYMNLNKADMDKFVKLRKLDHENLNKF----IGLSIDSSQFISVTKLC 638

  Fly  1047 TR--LIICLSVGTVILTF----CCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMC 1105
            :|  |:..|..|...:.|    |.:..:||                                   
 Worm   639 SRGSLLDILYKGNFSMDFFFMYCIIKDVAE----------------------------------- 668

  Fly  1106 MLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSAT--IHHNITISTPAS 1168
                            |.:..|..|||:   :.|:.            |||  ::.:..:.....
 Worm   669 ----------------GMSYLHKSFLRL---HGNLR------------SATCLVNDSWQVKLAEF 702

  Fly  1169 GGPTPLVDITSS-----GPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDA 1228
            |....|.:||.:     ..:.|.:|.:|.                                   .
 Worm   703 GFDQLLEEITPTKRRLLWAAPEVLRGSLT-----------------------------------V 732

  Fly  1229 SVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDS 1293
            |.|..|:|           ||::.:....:.|..:.:.|.:....      |..:| .:...|.|
 Worm   733 SQMDPSAD-----------VFSFAIIASEILTRKEAWDLKERKEG------YDEII-YRVKKGGS 779

  Fly  1294 FSLVELSRLGMPLGVQMLILLIS-----------FLVMVCYHAR-----------------LVEV 1330
            |.:.......:|.....||.|:.           ....:|...|                 |.|.
 Worm   780 FPIRPDIITDVPDVNPTLIALVKDCWAEAPEDRPTAENICEQLRDLMPKTKSNLMDHVFNMLEEY 844

  Fly  1331 TSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTD-ELYSKMHNLCGVMFA 1394
            ||.|: :..|:..:||| ::..:|  |.|:..:||..||....:.:..: |.:..:    .|.|:
 Worm   845 TSTLE-VEVEERTKELT-LEKKKA--DLLLSRMLPKQVAERLKAGQTVEPEGFDSV----TVFFS 901

  Fly  1395 SIPNFQDFYSEDIDNGKAC-----IRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGL-- 1452
            .:..|....|:       |     :.:||::..:||.::||   ..|.|::::|..|:..:||  
 Worm   902 DVVKFTILASK-------CTPFQVVNLLNDLYSNFDTIIEE---HGVYKVESIGDGYLCVSGLPT 956

  Fly  1453 ----NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNF----------QLRVGICSGP 1503
                ||             :..:|:.:....        |...||          :||:|:.|||
 Worm   957 RNGFNH-------------IKQIVDMSLKFM--------DYCKNFKIPHLPRERVELRIGVNSGP 1000

  Fly  1504 LVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCS---RGYTCVKRGEIAVKG 1565
            .|:||:|...|.|.::|:|||.||||:|.|:...:.:..:...||..   ..|....|||:.:||
 Worm  1001 CVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTSDAHLLLMKHFPHQYETNSRGEVIIKG 1065

  Fly  1566 KGMMTTFYVHPKGISESQLISP----------------VRMPAGIPLAQTPNLQRQTSHHGS 1611
            ||:|.||:|    :..|..|.|                ||.|      .||. .|..|.|||
 Worm  1066 KGVMETFWV----LGRSGDIEPSISNRSTPPVTQERFTVRAP------DTPE-ARSVSSHGS 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831 34/192 (18%)
CYCc 526..729 CDD:214485 44/236 (19%)
Guanylate_cyc 566..753 CDD:278633 40/218 (18%)
DUF1053 929..1020 CDD:283888 23/103 (22%)
CYCc 1353..1554 CDD:214485 55/225 (24%)
Guanylate_cyc 1381..1576 CDD:278633 59/218 (27%)
gcy-3NP_496037.1 PBP1_NPR_GC_like 36..453 CDD:107347 101/564 (18%)
ANF_receptor 54..433 CDD:279440 92/534 (17%)
PKc_like 554..823 CDD:304357 66/406 (16%)
HNOBA <839..882 CDD:285003 16/46 (35%)
CYCc 861..1051 CDD:214485 55/226 (24%)
Guanylate_cyc 888..1076 CDD:278633 60/226 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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