Protein Alignment Ac78C and gcy-1

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_496039.1
• Gene: gcy-1 / 191639
• WormBaseID: WBGene00001528
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 1470
• Identity: 280/1470 - (19%)
• Similarity: 495/1470 - (33%)
• Gaps: 528/1470 - (35%)

  Fly   327 SLIIVNVVDF--------VLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICF 383
            |:.:.|:.|.        .:||.:|....::.|.:|               ||||.|...:||..
 Worm    15 SIFVQNLPDTTVAPRTKRTIKIGIAAAQRIQTSSIG---------------WSVCGGAVPLAIER 64

  Fly   384 LGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVV 448
            |                      ...|||..    .|.||:|.|                ..|.:
 Worm    65 L----------------------KEMGFVKD----FDFEYIVDY----------------TECDL 87

  Fly   449 GGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIE 513
            |..:.|.     :..||....:..|.|.|.......:|:       |..|.|.:...|    |:
 Worm    88 GSVVRAG-----MEFIKTHKVDVIIGPPCAQALRLMSFL-------AENYKKPVLGWG----FV- 135

  Fly   514 THKAMEHKKESEKELQRTQKL--LDSILPN-IVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVS 575
                      |:.:|....:.  |.:::|| ::.....|:|              |..:..:.|:
 Worm   136 ----------SDTDLSDVIRFPHLTTVIPNSLMLGYAASKM--------------LTTFHWNRVA 176

  Fly   576 IL--FADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWK 638
            :|  |:|:|            ....::||:.|.|:..:..|  :.:.:..:.|.      :||..
 Worm   177 LLYYFSDVK------------YCSGVMNDIEATFNDPSTPN--VNIVIKAEIYL------NDNET 221

  Fly   639 TRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIAN 703
            |  |:...:|::...:|.......:... |..::|..|.      ::|::
 Worm   222 T--DNVFQTVKSRARIILWCTQTSVEKR-DYLIKIATHD------MIGDE--------------- 262

  Fly   704 HMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRS 768
                     .|||.                        |.|.||               .|||::
 Worm   263 ---------YVHIM------------------------LSMRNV---------------AFGTQT 279

  Fly   769 SAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAAT----IAVPA 829
            |             ...||     .|.||...|......|.||..   :..:.|||    :.|.:
 Worm   280 S-------------LGKPT-----FSQSGLTPIWESFTEGTDGFE---KMAKQAATRMFVLDVNS 323

  Fly   830 QQPTQLLQQQQKKNI--SLNSLP---NVVEGVAMDSRRIRNGCGVMGGAGG-------------T 876
            :...:...:..:|||  ::.|.|   :.||.:..::.       :|||...             |
 Worm   324 EVADKKYLEYMQKNIIKAVQSPPMNCSTVECMTANTT-------IMGGYARHLFDVVYLYGIALT 381

  Fly   877 GGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPF 941
            ....|.|....             :|.:.......|.|.:.      |.::...:.|. :|....
 Worm   382 HTNSTDPAVYG-------------DVDVLVHQFVTSFQGMT------GHVVISPNLTR-MPIFQL 426

  Fly   942 KNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKD 1006
            ..|||..|                  .||::|     |...|..:..|.          ||.:||
 Worm   427 YGLNSDYD------------------QVALVD-----FTYTNSVMVPNV----------TLFYKD 458

  Fly  1007 KSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRC--------------TRLIICLSVGT 1057
            :..                    .:|.:....:.:.||.|              .:::|.:::..
 Worm   459 EGG--------------------AVWSYYGHSRPLDIPICGFLGKSCPVSFWEQYKILIFVAIAV 503

  Fly  1058 VILTFCCVLVMAEEFPGLPRCL-----------KTNS------AKLVHQRQ--------RRTLFI 1097
            ::|   .||:|      :..||           :.|:      |||:...:        ||:|..
 Worm   504 IVL---MVLIM------IIGCLCVISGKRAERARINAEWQVPFAKLIESEKQVRGKGASRRSLQS 559

  Fly  1098 C--------GV--IVSMC-----MLSAIGLVLCP--SSTYIGTADEHSRFLRMVS-PYSNISMTE 1144
            .        ||  :...|     |:....:||..  ..|::..||: .||::|.. .:.||:..
 Worm   560 APSISTGHSGVTTVSDFCENYTMMMYEKEMVLTAKYQYTHLTKADK-ERFVKMRKLDHENINRF- 622

  Fly  1145 KEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSG--PSDEFVRSTLNALTLNLTPPLPQSHR 1207
                  :.||....|.|:::...|.|  .|.||.|.|  ..|.|.   :..:..::...|...|:
 Worm   623 ------IGLSIDSAHFISVTKLCSRG--SLQDILSRGNFSMDYFF---MFCIIRDVAKGLEYLHK 676

  Fly  1208 PYTLTTNGH---SVSLSNLSYSDASVMQSSSD--VEGQCAHPEYLVFTWV--------LCLVSLA 1259
            .: |..:|:   :..|.|.|: ...:.:...|  ||.|....:.|:  ||        |.:..:.
 Worm   677 TF-LRLHGNLRSATCLVNDSW-QVKLAEYGMDNLVEEQTPPKKRLL--WVAPEVLRGSLSVSQME 737

  Fly  1260 TALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVE--------LSRLGM-PLGVQMLI--- 1312
            .:..:|       :.|::|   :.|:.|..:.|.....|        :.:.|: |:..:::.
 Worm   738 PSADIY-------SFAIIA---SEILTKKEAWDILDRKEDCEEIVYNVKKGGLFPIRPEIITDIH 792

  Fly  1313 ----LLISFLVMVCY------------------------------HA--RLVEVTSRLDFIWKEQ 1341
                .||: ||..|:                              |.  .|.|.||.|:    |:
 Worm   793 DVNPALIA-LVKDCWAEVPEDRPTAENICSQMKGLVSKQKTNLMDHVFNMLEEYTSTLE----EE 852

  Fly  1342 AERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTD-ELYSKMHNLCGVMFASIPNFQDFYSE 1405
            .|.....:...:...|.|:..:||..||....:.:..: |.:..:    .|.|:.:..|....|:
 Worm   853 IEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSV----TVFFSDVVKFTILASK 913

  Fly  1406 DIDNGKAC-----IRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGL----NHEHLRLRG 1461
                   |     :.:||::..:||.::|:   ..|.|::::|..|:..:||    .:.|::
 Worm   914 -------CSPFQTVNLLNDLYSNFDTIIEQ---HGVYKVESIGDGYLCVSGLPTRNGYAHIK--- 965

  Fly  1462 ETSEDSVCDLVEFAFAMKQKLEEINGDAF--NNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVN 1524
                    .:|:.:....:..:..|....  .|.:||:|:.|||.|:||:|...|.|.::|:|||
 Worm   966 --------QIVDMSLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN 1022

  Fly  1525 VASRMDSTGENWRVQVPENTAELLCS---RGYTCVKRGEIAVKGKGMMTTFYVHPK-GISESQLI 1585
            .||||:|.|:...:.:..:...||.:   ..|....|||:.:||||:|.||:||.: |..|...:
 Worm  1023 TASRMESNGKPSLIHLTNDAHSLLTTHYPNQYETSSRGEVIIKGKGVMETFWVHGRFGEMEPTEL 1087

  Fly  1586 SPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKR 1625
            ..:...:..|:.....:...:|.|||..:.|:..||..::
 Worm  1088 RSISNRSTPPVTNDRWIPNPSSSHGSRPSSVYDPLQGHQK 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	44/234 (19%)
		Guanylate_cyc	566..753	CDD:425528	29/188 (15%)
		Adcy_cons_dom	929..1021	CDD:461877	16/91 (18%)
		Guanylate_cyc	1381..1576	CDD:425528	56/208 (27%)
gcy-1	NP_496039.1	PBP1_NPR_GC-like	35..451	CDD:380575	116/676 (17%)
		Protein Kinases, catalytic domain	555..821	CDD:473864	58/293 (20%)
		HNOBA	<839..883	CDD:462234	13/47 (28%)
		CYCc	862..1051	CDD:214485	51/213 (24%)