DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and gcy-11

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	852	Identity:	187/852 - (21%)
Similarity:	294/852 - (34%)	Gaps:	255/852 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GSDTKEEAPPEGGTMGGKSAAPREEGEPD-----ERVVLRRAVDKGAIALAQIDDLKLEGDD--- 111
            |..:|...||...|. .|..|..:....|     |...:..|.|.|.:.   .:.:|:.|..
Worm   346 GDASKTFCPPMCNTK-AKGIANNDPWSDDAYWYSESPSIVDAYDLGRLL---SETVKVHGASLLR 406

  Fly   112 DDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSK 176
            |.|::|  :.:.|.|:::.....|   :...||.........|...|||    ::..:..|:.:.
Worm   407 DPESLV--QTMSGRGVTSLLGYVT---KFNTNGVSQREYILWAPQQASS----SNGPIPLPEWAT 462

  Fly   177 IPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQTP------------- 228
            :      .|:|..:|.|:.        :.|..||   .|.|...|.:.:..|
Worm   463 L------AARMLPDGKGNY--------SIIWKNL---TQLGIFNGELPQSKPECGFNNELCPAGI 510

  Fly   229 ------------LRVQSVRIVEAKRAY-----GPKRRTESCSIFGNSNFEHDLESGNSLASIPGQ 276
                        :.|.::.|:....||     ..:||.|| |.|........|.......|..|.
Worm   511 RNLSELEIIVIAVCVVAILILVGVIAYIARWIAYERRLES-SYFLVHRKHVQLVDMTKFGSSRGG 574

  Fly   277 SQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHR----QRQKSLIIV------ 331
            |.......|.|.::....|.|......||..:::::.|:.:..:.:    .|.:.|.||
Worm   575 SMIQSAMSMRSQYEDSGPVGGATMNFYTNGIRKAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAK 639

  Fly   332 --NVVDFVLKI-------------------------VLAFVWIMRRSEL-------GP------- 355
              |.:..|.||                         :..|..::..|:|       ||
Worm   640 YENTLVTVRKINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPRKSLMDL 704

  Fly   356 IESDD---GTSMATAITWSVCCGI------------ANM--AICFL-GYWRCFANNY-------- 394
            :.:||   ......:....|..|:            .|:  :.|.: .|||...:||
Worm   705 LRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVE 769

  Fly   395 --------LHWAA------------------------VCTWVLFNIQGFVGQ-GVGFADREYLVW 426
                    |.|.|                        ....||:.|.|..|. |....|.:.::.
Worm   770 EPESKPDDLLWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIE 834

  Fly   427 YILFVIFVPYAMLPLPLKWCVVGGTIT-ASCHLAVITIIKLQHGEATINPEC------------- 477
            .:.|                ..||.:| ...||    |.|..:..|::..:|
Worm   835 QLKF----------------PDGGALTRPDIHL----ITKAPYPLASVVEKCWVEDPASRPSIKK 879

  Fly   478 ------VLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLD 536
                  .|.:.....|....:|:...|...|.|           ...|..::.|.|.:|.:.||.
Worm   880 VRELLKPLSKGLKGNIADNIMNLLDRYRNNLED-----------VIKERTEQLEDERKRNESLLL 933

  Fly   537 SILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILN 601
            .:||..|.|.:     |...| |:.:|       .|:|||.|:||.|||.|:||::..|:|.:||
Worm   934 QLLPKSVANSL-----KNGQP-VDAEF-------YDSVSIYFSDIVGFTALSSKSTPLQVVNMLN 985

  Fly   602 DLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTH 666
            :|:..||.|.:...|.:|:.:||.|..||.....|...   ||.......|.::.:||...:...
Worm   986 NLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYL---HAGEVASASLELLDSIKTFTVSHC 1047

  Fly   667 VD--LNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYE 729
            .|  |.:|||.|:|.|:.||:|.:...:.::.:.|||||.|||.|.|.|:.||       :||||
Worm  1048 PDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQIS-------SDAYE 1105

  Fly   730 VEPGNGG 736
            :....||
Worm  1106 LILKCGG 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	65/392 (17%)
		CYCc	526..729	CDD:214485	72/204 (35%)
		Guanylate_cyc	566..753	CDD:278633	64/173 (37%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651	26/118 (22%)
		PKc_like	640..890	CDD:389743	41/269 (15%)
		CYCc	923..1116	CDD:214485	76/213 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900