DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and gcy-32

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	122/486 - (25%)
Similarity:	200/486 - (41%)	Gaps:	123/486 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1125 DEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSG----PSD- 1184
            |:.|:.|    ||..:  .::..|| |...:.:|::|.......|  ||::.|....    |.|
Worm   229 DDFSKAL----PYHFV--IDESCKL-VQCGSELHNHIPNELLQPG--TPILRIFEINRPQIPLDF 284

  Fly  1185 EFVRSTLNAL-TLNL-TPPLPQSH-----------RPYTL-------TTNGHSVSLSNLSYSDAS 1229
            |.:.:.:||: .|.: |.||.:.|           ...||       .|.||.:.|
Worm   285 ENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMETLDEDATNELTQGHHLKL--------- 340

  Fly  1230 VMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLI--MMKFGSGD 1292
                    :||              ::.||:...:.||...         |.|.|  :|::|
Worm   341 --------KGQ--------------MMLLASKKHIIYLCSP---------YVTSINELMQYG--- 371

  Fly  1293 SFSLVELSRLGMPL--GVQMLILLISFLVMVCYHARL--VEVTSRLDFIWKEQAERELTNMKSNR 1353
                  :....|||  ..:.||||        ...||  |||..:|: ...||.|.....::..|
Worm   372 ------MRLTAMPLHDATRDLILL--------NQQRLSDVEVNLQLE-ANNEQLETMTRELELER 421

  Fly  1354 ALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILN 1418
            ...|:::|::||..:|...||.||.:    ...:...|||..:|.||....:  .:.|..:.:||
Worm   422 QKTDSILKDMLPRRIAQQLLSGEHIE----ACEHEATVMFCDLPAFQQAIPQ--CSPKDIVNMLN 480

  Fly  1419 EIICDFDELLEEPRFASVEKIKTVGATYMAAAGL---NHEHLRLRGETSEDSVCDLVEFAFAMKQ 1480
            ||....|.::.   ...|.|::||..:|||.:|:   ..||        .:::|.:   |..|..
Worm   481 EIFRKLDRIVV---IRGVYKVETVSDSYMAVSGIPDYTPEH--------AENMCHV---ALGMMW 531

  Fly  1481 KLEE-INGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENT 1544
            :... |:..:...|.||:||.||.:.:||:|...|.|.::|.||.:||:|:|.|...::|..:..
Worm   532 EARSVIDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGETVTLASQMESLGMAGKIQCSKWA 596

  Fly  1545 AELLCSRG-YTCVKRGEIAVKGKGMMTTFYV 1574
            .:.....| :....||.|.||.:|:..|:::
Worm   597 YQKAMETGRFEFSPRGRIDVKQRGLTETYFL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485	58/205 (28%)
		Guanylate_cyc	1381..1576	CDD:278633	55/199 (28%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002
		HNOBA	226..440	CDD:285003	63/277 (23%)
		CYCc	419..608	CDD:214485	58/208 (28%)
		Guanylate_cyc	452..627	CDD:278633	55/190 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810