DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac78C and daf-11

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_505960.3	Gene:	daf-11 / 179605	WormBaseID:	WBGene00000907	Length:	1077	Species:	Caenorhabditis elegans

Alignment Length:	280	Identity:	79/280 - (28%)
Similarity:	138/280 - (49%)	Gaps:	45/280 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 IIK-LQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEK 526
            :|| |::...::.|:..|.:...:.:|..:.::..:..|.||...|.|.  ||.|  ....|.||
Worm   669 LIKMLENCFGSVRPDIALARKIIDTVLKMSGSLVDLMIKNLTAYTQGLN--ETVK--NRTAELEK 729

  Fly   527 ELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKT 591
            |.::..:||..:||..|.|.:::.:  ..||       |:|    :|.:||::||.|||.|.|::
Worm   730 EQEKGDQLLMELLPKSVANDLKNGI--AVDP-------KVY----ENATILYSDIVGFTSLCSQS 781

  Fly   592 SAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQ-----FESDNWKTRPDHAVCSVETG 651
            ...::|.:|:.::.|||.|.......:::.:||. |||:.     .|.|:.|     ::|
Worm   782 QPMEVVTLLSGMYQRFDLIISQQGGYKMETIGDA-YCVAAGLPVVMEKDHVK-----SIC----- 835

  Fly   652 LHMIKAIKDVRLHTHVD--------LNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESG 708
              ||..::...|| |.:        ||.|.|.:||.|..||:|.|...:..:...||:|:.|||.
Worm   836 --MIALLQRDCLH-HFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESS 897

  Fly   709 GIPGRVHISEATLKCLNDAY 728
            |:..|:.::.|:.:.|.:.:
Worm   898 GVEDRIQMTLASQQLLEENF 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	24/88 (27%)
		CYCc	526..729	CDD:214485	63/216 (29%)
		Guanylate_cyc	566..753	CDD:278633	52/176 (30%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141
		PKc_like	447..695	CDD:304357	5/25 (20%)
		HNOBA	<714..750	CDD:285003	15/39 (38%)
		CYCc	729..922	CDD:214485	63/216 (29%)
		Guanylate_cyc	756..943	CDD:278633	55/187 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810