DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac78C and gcy-18

DIOPT Version :9

Sequence 1:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	222	Identity:	66/222 - (29%)
Similarity:	109/222 - (49%)	Gaps:	30/222 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 RTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQ 594
            |..:||..:||..|.|:::  |.:...|       |||    .:.:|||:||.|||.:.|.::..
Worm   886 RADQLLTQLLPAYVANELK--MGRSVAP-------KLY----SSATILFSDIVGFTTICSGSTPL 937

  Fly   595 QLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIK 659
            ::|.:||.|:..||.....|...:|:.:||.|..||....:|   ..:|:.....|.|.|.:.:.
Worm   938 EVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEEN---EYNHSRNIANTALDMRQYLT 999

  Fly   660 DVRL-H--THVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEAT- 720
            ..:: |  || .:..|.|.|:|||..||:|.....:.::.:.|.:::.|||.|.||.:.:||..
Worm  1000 GYQIPHRPTH-RVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAH 1063

  Fly   721 --LKCLNDAY------EVE-PGNGGCR 738
              ::..:..:      ||: .|.|.||
Worm  1064 MHIRAHHPVFTTTERGEVQVKGKGTCR 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	7/20 (35%)
		CYCc	526..729	CDD:214485	60/210 (29%)
		Guanylate_cyc	566..753	CDD:278633	56/186 (30%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141
		ANF_receptor	87..395	CDD:279440
		PKc_like	549..846	CDD:304357
		HNOBA	<857..903	CDD:285003	7/16 (44%)
		CYCc	882..1073	CDD:214485	60/203 (30%)
		Guanylate_cyc	909..1095	CDD:278633	58/197 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810